Results 181 to 190 of about 10,379,704 (316)

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Increased incidence of mild cognitive impairment in long COVID patients

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Though brain fog is common in Long‐coronavirus disease 2019 (Long‐COVID), the incidence of mild cognitive impairment (MCI) is unknown. METHODS In an observational cohort study, recovered COVID‐positive, Long‐COVID, and COVID‐negative subjects underwent blinded evaluation using National Alzheimer's Coordinating Center (NACC) and ...
Jennifer A. Frontera, Arjun V. Masurkar, Rebecca A. Betensky, Zariya Alvarez, Allal Boutajangout, Joshua Chodosh, Salma Hammam, Jessica Hunter, Li Jiang, Melanie Li, Jon Links, Karyn Marsh, Huize Pang, Floyd Silva, Sujata Thawani, Daria Vasilchenko, Alok Vedvyas, Amin Yakubov, Yulin Ge, Thomas Wisniewski   +19 more
wiley   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, Volume 99, Issue 3, Page 614-628, March 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Fractional Order Epidemic System of Saturated Rate of Incidence: A Neural Network Approach

Engineering Reports, Volume 8, Issue 3, March 2026.
The workflow depictions of the mathematical fractional order saturated rate of incidence model using the process of Levenberg–Marquardt Backpropagation neural network. The designed neural network contains 20 numbers of neurons, a sigmoid activation function, and a single hidden layer structure.
Zulqurnain Sabir, M. A. Abdelkawy, Muhammad Umar, Soheil Salahshour   +3 more
wiley   +1 more source

Repeated Episodes of GPP Induced by Respiratory Infections Are Mediated by Loss‐of‐Function IFIH1

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Generalized pustular psoriasis (GPP) is a severe and recurrent autoinflammatory disease that can be induced by a variety of factors. At present, its etiology and pathogenesis have not yet been fully elucidated. Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by ...
Yaqin Liu, Yanan Sun, Juan Yang, Hongmei Li, Weihui Zhou, Shasha Meng   +5 more
wiley   +1 more source

Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases

Veterinary Research
Prion diseases are fatal and contagious brain disorders caused by a pathogenic prion protein (PrPSc) derived from the benign prion protein (PrPC). To date, there are no therapeutic substances to completely block prion diseases. Thus, the development of a
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Plasmonics‐Enhanced Characterization of Cervid PrP (87–114) Fragment Aggregates in Solution

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Multimodal nanophotonics platform combining plasmon‐enhanced imaging, label‐free SERS, and optical staining reveals new insights into the aggregation of the cervid PrP (87–114) fragment, an amyloidogenic sequence linked to chronic wasting disease susceptibility.ABSTRACTWe performed a multimodal characterisation of self‐assembled fibrillar aggregates ...
Shinki Midha, Aishwarya Sriraman, Lyudmyla Dorosh, Holger Wille, Maria Stepanova   +4 more
wiley   +1 more source

Palliative Care Resource Utilization in Patients with Prion Disease [PDF]

Alzheimers Dement
Day G, Zayat R, Piura Y, Appleby B, Robinson M.   +4 more
europepmc   +2 more sources

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Neurons depend on tightly regulated spatial proteostasis to maintain function across their extended morphology. The endoplasmic reticulum (ER), traditionally known for its function in protein synthesis, folding, and trafficking, has long been recognized as a central platform for directing proteins to organelles of the secretory and endocytic ...
J. Tabitha Hees, Angelika B. Harbauer
wiley   +1 more source