Results 221 to 230 of about 51,393 (297)

In vivo base editing extends lifespan of a humanized mouse model of prion disease. [PDF]

Nat Med
An M, Davis JR, Levy JM, Serack FE, Harvey JW, Brauer PP, Pirtle CP, Berríos KN, Newby GA, Yeh WH, Kamath N, Mortberg M, Lian Y, Howard M, DeSouza-Lenz K, Guzman K, Thai A, Graffam S, Laversenne V, Coffey AA, Frei J, Pierce SE, Safar JG, Deverman BE, Minikel EV, Vallabh SM, Liu DR.   +26 more
europepmc   +1 more source

Mimicking the Ocean: Critical Challenges in Scaffold Design and Tissue Texturization for Cell‐Cultured Seafood

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT Cellular aquaculture offers a sustainable solution to global seafood demand, yet the production of high‐value, whole‐cut fillets is hindered by the “texture gap,” the inability to replicate the complex, anisotropic architecture of native fish muscle and its collagenous myosepta.
Mustafa Öz, Enes Üstüner
wiley   +1 more source

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector. [PDF]

Pathogens
Zhang J, Wang M, Wang D, Zhang X, Ma Y, Pardon E, Steyaert J, Abskharon R, Wang F, Ma J.   +9 more
europepmc   +1 more source

RORA Targeting PRNP Modulates Age‐Related Cataract via Activation Oxidative Injury‐Induced Cellular Senescence and Apoptosis of Lens Epithelial Cells

Aging Cell, Volume 25, Issue 6, June 2026.
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Yue Zou, Wanqian Li, Jiaojiao Zhang, Chao Cen, Wanqiu Zheng, Ruonan Li, Hong Cheng, Liang Liang, Juan Kang, Wenjuan Wan, Ke Hu, Shijie Zheng   +11 more
wiley   +1 more source

Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease. [PDF]

Nat Med
An M, Davis JR, Levy JM, Serack FE, Harvey JW, Brauer PP, Pirtle CP, Berríos KN, Newby GA, Yeh WH, Kamath N, Mortberg M, Lian Y, Howard M, DeSouza-Lenz K, Guzman K, Thai A, Graffam S, Laversenne V, Coffey AA, Frei J, Pierce SE, Safar JG, Deverman BE, Minikel EV, Vallabh SM, Liu DR.   +26 more
europepmc   +1 more source

Active Chlorine Antiseptics in Wound Care: Recent Advances and Perspectives for Military Medicine

APMIS, Volume 134, Issue 6, June 2026.
ABSTRACT The spread of multidrug‐resistant microorganisms remains a major global challenge that continues to worsen. Modern military conflicts intensify this problem by forcing healthcare systems to manage large numbers of patients with complex, heavily contaminated injuries in resource‐limited settings.
Bohdan Murashevych, Dmytro Stepanskyi, William M. Wuest, Tim Holm Jakobsen   +3 more
wiley   +1 more source

Supportive care or exhausted neglect: the role of microglia at the end stage of prion disease. [PDF]

J Clin Invest
Lawson VA.
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease. [PDF]

Front Neurosci
Carpanini SM, Bradford BM, Alfieri A, Piccardo P, Monzón-Sandoval J, Brown D, Boyle A, Pokrovskaya A, Mabbott NA, Manson J, McColl BW.   +10 more
europepmc   +1 more source

Delayed progression of prion disease in mice by polyarginine-facilitated prevention of PrP^Sc propagation in the spleen. [PDF]

Neurotherapeutics
Lee S, Kim J, Lee Y, Yoo M, Kim J, Sohn HJ, Ryou C.   +6 more
europepmc   +1 more source