Rapid Typing of Transmissible Spongiform Encephalopathy Strains with Differential ELISA [PDF]
Emerging Infectious Diseases, 2008 The bovine spongiform encephalopathy (BSE) agent has been transmitted to humans, leading to variant Creutzfeldt-Jakob disease. Sheep and goats can be experimentally infected by BSE and have been potentially exposed to natural BSE; however, whether BSE ...
Stéphanie Simon +12 more
doaj +5 more sources
Improving Clinical Diagnosis of Transmissible Spongiform Encephalopathies in Sheep: Which Signs Are Important? [PDF]
AnimalsScrapie is a notifiable transmissible spongiform encephalopathy (TSE) in sheep that relies on clinical examinations for reporting suspects. A short examination protocol was used in 1002 sheep to define clinical markers suggestive of scrapie.
Timm Konold, Laura J. Phelan
doaj +2 more sources
Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine [PDF]
Emerging Infectious Diseases, 2008 The route of transmission of most naturally acquired transmissible spongiform encephalopathy (TSE) infections remains speculative. To investigate urine as a potential source of TSE exposure, we used a sensitive method for detection and quantitation of ...
Luisa Gregori +4 more
doaj +2 more sources
Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype? [PDF]
Journal of Veterinary Diagnostic Investigation, 2020 Leigh Thorne +2 more
exaly +2 more sources
CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis [PDF]
BioImpacts, 2022 Introduction: The limited efficacy of BCG (bacillus Calmette–Guérin) urgently requires new effective vaccination approaches for the control of tuberculosis. Poly lactic-co-glycolic acid (PLGA) is a prevalent drug delivery system.
Zhengmin Liang +8 more
doaj +1 more source
Post‐translational changes to PrP alter transmissible spongiform encephalopathy strain properties [PDF]
EMBO Journal, 2013 Enrico Cancellotti +2 more
exaly +2 more sources
Transmissible spongiform encephalopathies
Journal of the American Veterinary Medical Association, 2008 Abstract Transmissible spongiform encephalopathies (TSEs), or prion diseases, are invariably fatal neurodegenerative diseases of humans and animals. TSEs are believed to be caused by neuronal accumulation of a protease-resistant abnormal conformer of a host-encoded protein known as prion protein.
James J, Sejvar +2 more
+8 more sources
PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
doaj +1 more source
Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile [PDF]
Brain Pathology, 2012 Katy E Beck +2 more
exaly +2 more sources
Implications of gut microbiota dysbiosis and metabolic changes in prion disease
Neurobiology of Disease, 2020 Evidence of the gut microbiota influencing neurodegenerative diseases has been reported for several neural diseases. However, there is little insight regarding the relationship between the gut microbiota and prion disease. Here, using fecal samples of 12
Dongming Yang +12 more
doaj +1 more source