Results 11 to 20 of about 20,782 (249)

Post‐translational changes to PrP alter transmissible spongiform encephalopathy strain properties [PDF]

EMBO J, 2013
E. Cancellotti, S. Mahal, R. Somerville, Abigail B. Diack, Deborah Brown, P. Piccardo, C. Weissmann, J. Manson   +7 more
semanticscholar   +4 more sources

Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy [PDF]

PLoS Pathog, 2017
Aggregation of misfolded proteins or peptides is a common feature of neurodegenerative diseases including Alzheimer’s, Parkinson’s, Huntington’s, prion and other diseases.
E. Katorcha, N. Makarava, Young Jin Lee, I. Lindberg, M. Monteiro, G. Kovacs, I. Baskakov   +6 more
semanticscholar   +2 more sources

The Glycosylation Status of PrPC Is a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between Species [PDF]

J Virol, 2015
The risk of transmission of transmissible spongiform encephalopathies (TSE) between different species has been notoriously unpredictable because the mechanisms of transmission are not fully understood.
F. Wiseman, E. Cancellotti, P. Piccardo, Kayleigh Iremonger, A. Boyle, Deborah Brown, J. Ironside, J. Manson, Abigail B. Diack   +8 more
semanticscholar   +2 more sources

Strain Traits of Intracranially Administered L‐Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys [PDF]

Microbiology and Immunology, Volume 70, Issue 3, Page 166-174, March 2026.
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Ken'ichi Hagiwara, Hiroaki Shibata, Minoru Tobiume, Yuko Sato, Keiko Ohto, Sachi Okabayashi, Nozomi Nakano, Motohiro Horiuchi, Fumiko Ono   +8 more
wiley   +2 more sources

Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile [PDF]

Brain Pathol, 2011
Two cases of unusual transmissible spongiform encephalopathy (TSE) were diagnosed on the same farm in ARQ/ARQ PrP sheep showing attributes of both bovine spongiform encephalopathy (BSE) and scrapie.
K. Beck, R. Sallis, R. Lockey, Christopher M. Vickery, V. Béringue, H. Laude, Thomas M. Holder, L. Thorne, L. Terry, A. C. Tout, D. Jayasena, P. C. Griffiths, S. Cawthraw, R. Ellis, A. Balkema-Buschmann, M. Groschup, M. Simmons, J. Spiropoulos   +17 more
semanticscholar   +2 more sources

Improving Clinical Diagnosis of Transmissible Spongiform Encephalopathies in Sheep: Which Signs Are Important? [PDF]

Animals
Scrapie is a notifiable transmissible spongiform encephalopathy (TSE) in sheep that relies on clinical examinations for reporting suspects. A short examination protocol was used in 1002 sheep to define clinical markers suggestive of scrapie.
Timm Konold, Laura J. Phelan
doaj   +2 more sources

Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain [PDF]

BMC Res Notes, 2015
Background The infectious agent responsible for the bovine spongiform encephalopathy (BSE) epidemic in Great Britain is a transmissible spongiform encephalopathy (TSE) strain with uniform properties but the origin of this strain remains unknown. Based on
Timm Konold, Romolo Nonno, John Spiropoulos, Melanie J Chaplin, Michael J Stack, Steve A C Hawkins, Saira Cawthraw, John W Wilesmith, Gerald A H Wells, Umberto Agrimi, Michele A Di Bari, Olivier Andréoletti, Juan C Espinosa, Patricia Aguilar-Calvo, Juan M Torres   +14 more
core   +2 more sources

Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine [PDF]

Emerging Infectious Diseases, 2008
The route of transmission of most naturally acquired transmissible spongiform encephalopathy (TSE) infections remains speculative. To investigate urine as a potential source of TSE exposure, we used a sensitive method for detection and quantitation of ...
Luisa Gregori, Gabor G. Kovacs, Irina Alexeeva, Herbert Budka, Robert G. Rohwer   +4 more
doaj   +2 more sources

Mechanism of PrP‐Amyloid Formation in Mice Without Transmissible Spongiform Encephalopathy [PDF]

Brain Pathol, 2012
M. Jeffrey, G. McGovern, Emily V. Chambers, Declan King, L. González, J. Manson, B. Ghetti, P. Piccardo, R. Barron   +8 more
semanticscholar   +2 more sources

Rapid Typing of Transmissible Spongiform Encephalopathy Strains with Differential ELISA [PDF]

Emerging Infectious Diseases, 2008
The bovine spongiform encephalopathy (BSE) agent has been transmitted to humans, leading to variant Creutzfeldt-Jakob disease. Sheep and goats can be experimentally infected by BSE and have been potentially exposed to natural BSE; however, whether BSE ...
Stéphanie Simon, Jérôme Nugier, Nathalie Morel, Hervé Boutal, Christophe Créminon, Sylvie L. Benestad, Olivier Andréoletti, Frédéric Lantier, Jean-Marc Bilheude, Muriel Feyssaguet, Anne-Gaëlle Biacabe, Thierry Baron, Jacques Grassi   +12 more
doaj   +2 more sources