Results 31 to 40 of about 4,885 (171)

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Frontiers in Neurology, 2019
It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis.
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang   +12 more
doaj   +1 more source

The Spectrum of Transmissible Spongiform Encephalopathies

Intervirology, 1997
Since the first description by A.M. Jakob and H.G. Creutzfeldt, five human diseases have been identified as transmissible spongiform encephalopathies (TSE). The disease bearing these authors' name, Creutzfeldt-Jakob disease (CJD) occurs sporadically, may be transmitted and has a genetic basis in 10-15% of all cases.
Weber, T, Aguzzi, A
openaire   +2 more sources

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Frontiers in Immunology, 2019
Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages and induces endoplasmic reticulum stress (ERS), mitochondrial damage, and interleukin (IL)-1β production. The relationship between these phenotypes is
Yi Liao, Tariq Hussain, Chunfa Liu, Yongyong Cui, Jie Wang, Jiao Yao, Hehua Chen, Yinjuan Song, Naveed Sabir, Mazhar Hussain, Deming Zhao, Xiangmei Zhou   +11 more
doaj   +1 more source

MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 Binding Protein 2

Frontiers in Immunology, 2018
Mycobacterium avium subspecies paratuberculosis (MAP) persistently survive and replicate in mononuclear phagocytic cells by adopting various strategies to subvert host immune response.
Tariq Hussain, Deming Zhao, Syed Zahid Ali Shah, Jie Wang, Ruichao Yue, Yi Liao, Naveed Sabir, Lifeng Yang, Xiangmei Zhou   +8 more
doaj   +1 more source

MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in
Jie Wang, Tariq Hussain, Ruichao Yue, Yi Liao, Qiang Li, Jiao Yao, Yinjuan Song, Xin Sun, Nan Wang, Lei Xu, Srinand Sreevatsan, Deming Zhao, Xiangmei Zhou   +12 more
doaj   +1 more source

The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

Frontiers in Aging Neuroscience, 2017
Prion diseases are neurodegenerative pathologies characterized by the accumulation of a protease-resistant form of the cellular prion protein named prion protein scrapie (PrPSc) in the brain. PrPSc accumulation in the endoplasmic reticulum (ER) result in
Lifeng Yang, Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain   +3 more
doaj   +1 more source

Transmissible Spongiform Encephalopathies in Humans [PDF]

Annual Review of Microbiology, 1999
▪ Abstract  Creutzfeldt-Jakob disease (CJD), the first transmissible spongiform encephalopathy (TSE) to be described in humans, occurs in a sporadic, familial, or iatrogenic form. Other TSEs in humans, shown to be associated with specific prion protein gene mutations, have been reported in different parts of the world.
openaire   +3 more sources

The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection

Frontiers in Cellular and Infection Microbiology, 2017
Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy ...
Liu Chunfa, Sun Xin, Li Qiang, Srinand Sreevatsan, Lifeng Yang, Deming Zhao, Xiangmei Zhou   +6 more
doaj   +1 more source

Transmissible spongiform encephalopathies in Australia

Communicable Diseases Intelligence, 2001
The Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR) commenced surveillance in September 1993 as part of the Commonwealth's response to 4 cases of pituitary hormone (gonadotrophin)-associated Creutzfeldt-Jakob disease (CJD). With the passage of time, the Registry has become responsible for ascertaining all human transmissible spongiform ...
A, Boyd, A, Fletcher, J S, Lee, V, Lewis, C L, Masters, S J, Collins   +5 more
openaire   +2 more sources

Do More Open Economies Export Less Diversely in Brazilian Agribusiness?

Agribusiness, EarlyView.
ABSTRACT This paper asks whether municipalities with a larger export‐to‐revenue ratio display a more concentrated bundle of exported goods in Brazilian agribusiness. Recent advances in export imputation for Brazilian municipalities allow for an analysis of the concentration profile of each municipality and its association with export openness.
Alan Leal, Michelle Marcia Viana Martins
wiley   +1 more source