Results 31 to 40 of about 20,782 (249)

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Frontiers in Neurology, 2019
It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis.
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang   +12 more
doaj   +1 more source

Prion diseases are efficiently transmitted by blood transfusion in sheep [PDF]

, 2008
The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly ...
Andréoletti, Angela Chong, Bishop, Brown, Castilla, Clarke, Fiona Houston, Goldmann, Goldmann, Goldmann, González, González, Gregori, Gregori, Hadlow, Hewitt, Hill, Hilton, Houston, Houston, Hunter, Ironside, James Foster, Jeffrey, Jeffrey, Jeffrey, Kirby, Llewelyn, Lorenzo González, Martin Jeffrey, Mead, Nora Hunter, O'Rourke, Peden, Sandra McCutcheon, Saá, Schreuder, Silvia Sisó, Sisó, Valleron, van Keulen, Wilfred Goldmann, Will, Wroe   +43 more
core   +1 more source

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrP in vivo [PDF]

, 2007
Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form of
Barron, R. M., Bellon, A., Campbell, S. L., Chapman, K. E., King, Declan, Manson, J., Williamson, R. A.   +6 more
core   +1 more source

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Frontiers in Immunology, 2019
Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages and induces endoplasmic reticulum stress (ERS), mitochondrial damage, and interleukin (IL)-1β production. The relationship between these phenotypes is
Yi Liao, Tariq Hussain, Chunfa Liu, Yongyong Cui, Jie Wang, Jiao Yao, Hehua Chen, Yinjuan Song, Naveed Sabir, Mazhar Hussain, Deming Zhao, Xiangmei Zhou   +11 more
doaj   +1 more source

Reasoning under uncertainty: the role of two informal fallacies in an emerging scientific inquiry [PDF]

, 2002
It is now commonplace in fallacy inquiry for many of the traditional informal fallacies to be viewed as reasonable or non-fallacious modes of argument.
Cummings, L
core   +1 more source

Bovine Spongiform Encephalopathy 
– A Review from the Perspective of Food Safety

Food Safety, 2019
Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease that belongs to transmissible spongiform encephalopathy (TSE). Since the first case was identified in the UK in 1986, BSE spread to other countries including Japan. Its incidence
S. Kumagai, Takateru Daikai, T. Onodera
semanticscholar   +1 more source

MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 Binding Protein 2

Frontiers in Immunology, 2018
Mycobacterium avium subspecies paratuberculosis (MAP) persistently survive and replicate in mononuclear phagocytic cells by adopting various strategies to subvert host immune response.
Tariq Hussain, Deming Zhao, Syed Zahid Ali Shah, Jie Wang, Ruichao Yue, Yi Liao, Naveed Sabir, Lifeng Yang, Xiangmei Zhou   +8 more
doaj   +1 more source

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe [PDF]

, 2010
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host.
Acín, C., Badiola, J.J., Balkema-Buschmann, A., Casalone, C., González, L., Hoffmann, C., Jeffrey, M., Keulen, L.J.M., van, Langeveld, J.P.M., Lulini, B., Monleón, E., Ortiz-Peláez, A., Sisó, S.   +12 more
core   +2 more sources

MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in
Jie Wang, Tariq Hussain, Ruichao Yue, Yi Liao, Qiang Li, Jiao Yao, Yinjuan Song, Xin Sun, Nan Wang, Lei Xu, Srinand Sreevatsan, Deming Zhao, Xiangmei Zhou   +12 more
doaj   +1 more source

Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (bse) and scrapie in Great Britain [PDF]

, 2017
Transmissible spongiform encephalopathies (TSEs) are an important public health concern. Since the emergence of bovine spongiform encephalopathy (BSE) during the 1980s and its link with human Creutzfeldt- Jakob disease, active surveillance has been a key
Arnold, Arnold, Arnold, Boqvist, Cassard, Comoy, Del Rio Vilas, Detwiler, Gafni, Garber, Gill, Gubbins, Maheshwari, McCabe, Prattley, Wells, Wilesmith   +16 more
core   +3 more sources