Results 51 to 60 of about 20,782 (249)

An overview of animal prion diseases

Virology Journal, 2011
Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion ...
Imran Muhammad, Mahmood Saqib
doaj   +1 more source

Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. [PDF]

PLoS ONE, 2013
Prion diseases are rare but invariably fatal neurodegenerative disorders. They are associated with spongiform encephalopathy, a histopathology characterized by the presence of large, membrane-bound vacuolar structures in the neuropil of the brain.
Derek Silvius, Rose Pitstick, Misol Ahn, Delisha Meishery, Abby Oehler, Gregory S Barsh, Stephen J DeArmond, George A Carlson, Teresa M Gunn   +8 more
doaj   +1 more source

microRNA-146a as a biomarker for transmissible spongiform encephalopathy

Folia Neuropathologica, 2022
The pro-inflammatory, innate-immune system ribonucleic acid mediator microRNA-146a, constitutively expressed in the brain and central nervous system (CNS) of both the mouse and the human, is pathologically up-regulated in multiple transmissible ...
Aileen Pogue, Yuhai Zhao, Walter Lukiw
doaj   +1 more source

Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study [PDF]

, 2008
The aim of this study was to analyze molecular features of protease-resistant prion protein (PrPres) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status.
Jacobs, J.G., Langeveld, J.P.M., Polak, M.P., Zmudzinski, J.F.   +3 more
core   +1 more source

Differentiation of Plant and Animal‐Derived Cholesterol Using irm‐13C NMR and IRMS

Magnetic Resonance in Chemistry, EarlyView.
Determining and certifying the origin of ingredients, starting materials, and excipients used in manufactured goods like cosmetics and medicines can be difficult. In this report, we describe a robust approach for identifying the origin of cholesterol, a component of myriad consumer products using irm‐13C NMR and IRMS to differentiate plant versus ...
Anika M. Singh, Subir Chakraborty, Remington X. Poulin, R. Thomas Williamson   +3 more
wiley   +1 more source

Defensins: The Case for Their Use against Mycobacterial Infections

Journal of Immunology Research, 2016
Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial
Haodi Dong, Yue Lv, Deming Zhao, Paul Barrow, Xiangmei Zhou   +4 more
doaj   +1 more source

RT-QuIC detection of pathological prion protein in subclinical goats following experimental oral transmission of L-type BSE

BMC Research Notes, 2021
Objective The spread of bovine spongiform encephalopathy (BSE) agent to small ruminants is still a major issue in the surveillance of transmissible spongiform encephalopathies (TSEs). L-type bovine spongiform encephalopathy (L-BSE) is an atypical form of
Alessandra Favole, Maria Mazza, Antonio D’Angelo, Guerino Lombardi, Claudia Palmitessa, Luana Dell’Atti, Giulia Cagnotti, Elena Berrone, Marina Gallo, Tiziana Avanzato, Erika Messana, Loretta Masoero, Pier Luigi Acutis, Daniela Meloni, Franco Cardone, Maria Caramelli, Cristina Casalone, Cristiano Corona   +17 more
doaj   +1 more source

Unveiling human–wildlife interactions in the context of livestock grazing abandonment and the return of large carnivores, ungulates and vultures: A stakeholder perspective

People and Nature, EarlyView.
Abstract Pastoral practices remain a widespread economic activity across European mountain regions. However, the viability of this activity may be threatened by the recovery of large wild vertebrates associated with passive rewilding, leading to the so‐called human–wildlife conflicts.
P. Acebes, F. J. Muñoz‐Gálvez, Z. Iglesias‐González, M. García‐Llorente, D. López‐García   +4 more
wiley   +1 more source

Rapid selection of single-stranded DNA aptamers binding Staphylococcus epidermidis in platelet concentrates

BioTechniques, 2018
Staphylococcus epidermidis is the most common transfusion-associated pathogen contaminating platelet concentrates. Methods to reduce or eliminate contaminating bacteria from platelet units are critical for improving the safety of blood transfusions.
Simran J Kaur, Vladimir Gilman, Minh Duong, David M Asher, Luisa Gregori   +4 more
doaj   +1 more source

Identification of a Heritable Polymorphism in Bovine PRNP Associated with Genetic Transmissible Spongiform Encephalopathy: Evidence of Heritable BSE

PLoS ONE, 2008
Background Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy (TSE) of cattle. Classical BSE is associated with ingestion of BSE-contaminated feedstuffs.
E. Nicholson, B. Brunelle, J. Richt, M. Kehrli, J. Greenlee   +4 more
semanticscholar   +1 more source