Results 61 to 70 of about 6,019 (214)

Proteinase K-Resistant Material in ARR/VRQ Sheep Brain Affected with Classical Scrapie Is Composed Mainly of VRQ Prion Protein [PDF]

, 2011
Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions.
Bossers, A., A. Bossers, T. Sklaviadis, I. Lantier, F. Lantier, L. J. M. van Keulen, Van Keulen, L., S. McCutcheon, Berthon, P., Lantier, Isabelle, van Keulen, L.J.M., van Zijderveld, F.G., P. Berthon, Lantier, Frédéric, F., Zijderveld, F.G., van, Jacobs, J.G., Keulen, L., Van, Langeveld, J.P.M., Lantier, I., H. Rezaei, J. P. M. Langeveld, Rezaei, Human, Sklaviadis, T., Berthon, Patricia, J. G. Jacobs, F. G. van Zijderveld, Lantier, F., McCutcheon, S., Rezaei, H.   +28 more
core   +1 more source

Harvest increase and culling as tools for managing chronic wasting disease in white‐tailed deer

The Journal of Wildlife Management, Volume 90, Issue 5, July 2026.
We used an agent‐based model to simulate the effect of CWD management on a white‐tailed deer population in northwest Indiana and northeast Illinois. Our results suggest that wildlife managers should reconsider how and if they should manage CWD. Abstract Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects white‐tailed ...
Jonathan D. Brooks, Aniruddha V. Belsare, Joe N. Caudell, Patrick A. Zollner   +3 more
wiley   +1 more source

A Practical Framework for GT‐Seq Panel Optimization

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Genotyping‐in‐thousands by sequencing (GT‐seq) panels are powerful tools in ecological, evolutionary and conservation genomics, yet the optimization process critical for robust and reproducible genotyping remains poorly formalized. Here, we present an iterative workflow for GT‐seq panel optimization that emphasizes systematic refinement ...
Chandika RG, Caitlin N. Ott‐Conn, Peter T. Euclide, Julie A. Blanchong, Angela Schmoldt, Randy W. DeYoung, Daniel P. Walsh, Wes A. Larson, Emily K. Latch   +8 more
wiley   +1 more source

Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies

Emerging Infectious Diseases, 2011
Transmissible spongiform encephalopathy (TSE) agents have contaminated human tissue–derived medical products, human blood components, and animal vaccines.
Pedro Piccardo, Larisa Cervenakova, Irina Vasilyeva, Oksana Yakovleva, Igor Bacik, Juraj Cervenak, Carroll McKenzie, Lubica Kurillova, Luisa Gregori, Kitty Pomeroy, David M. Asher   +10 more
doaj   +1 more source

Detection and localisation of PrP(Sc) in the liver of sheep infected with scrapie and bovine spongiform encephalopathy. [PDF]

PLoS ONE, 2011
Prions are largely contained within the nervous and lymphoid tissue of transmissible spongiform encephalopathy (TSE) infected animals. However, following advances in diagnostic sensitivity, PrP(Sc), a marker for prion disease, can now be located in a ...
Sally J Everest, Andrew M Ramsay, Melanie J Chaplin, Sharon Everitt, Michael J Stack, Michael H Neale, Martin Jeffrey, S Jo Moore, Susan J Bellworthy, Linda A Terry   +9 more
doaj   +1 more source

From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption

Agricultural Economics, Volume 57, Issue 4, July 2026.
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley   +1 more source

Hypotheses on the origin and transmission of BSE

Veterinární Medicína, 2001
EC Health & Consumer Protection Directorate-General recently published an important document based on papers and reviews discussed by members of TSE/BSE ad hoc group.
K. Hruška
doaj   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases

Cell Death and Disease
Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding of cellular prion proteins into pathogenic forms.
Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang   +11 more
doaj   +1 more source

Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction

Pathogens, 2013
Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture ...
Pawel P. Liberski
doaj   +1 more source