Results 41 to 50 of about 6,019 (214)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

TSE pathogenesis in cattle and sheep

, 2008
Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A., Fred van Zijderveld, Lucien J.M. van Keulen, van Zijderveld, Fred, Keulen, L.J.M., van, van Keulen, L.J.M., van Zijderveld, F.G., Zijderveld, F.G., van, Bossers, Alex, van Keulen, Lucien, Alex Bossers   +10 more
core   +1 more source

An overview of animal prion diseases

Virology Journal, 2011
Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion ...
Imran Muhammad, Mahmood Saqib
doaj   +1 more source

Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. [PDF]

PLoS ONE, 2013
Prion diseases are rare but invariably fatal neurodegenerative disorders. They are associated with spongiform encephalopathy, a histopathology characterized by the presence of large, membrane-bound vacuolar structures in the neuropil of the brain.
Derek Silvius, Rose Pitstick, Misol Ahn, Delisha Meishery, Abby Oehler, Gregory S Barsh, Stephen J DeArmond, George A Carlson, Teresa M Gunn   +8 more
doaj   +1 more source

microRNA-146a as a biomarker for transmissible spongiform encephalopathy

Folia Neuropathologica, 2022
The pro-inflammatory, innate-immune system ribonucleic acid mediator microRNA-146a, constitutively expressed in the brain and central nervous system (CNS) of both the mouse and the human, is pathologically up-regulated in multiple transmissible ...
Aileen Pogue, Yuhai Zhao, Walter Lukiw
doaj   +1 more source

Causal analysis of trade loss from pathogens: A global study of foot and mouth disease impacts on meat exports

American Journal of Agricultural Economics, EarlyView.
Abstract Our general interest is in global trade loss from livestock pathogens, specifically exports. We adopt a causal inference approach that considers animal disease outbreaks over time as non‐staggered binary treatments with the potential for switching in (infection) and out of treatment (recovery) within the sample period. The outcome evolution of
Mohammad Maksudur Rahman, Thomas L. Marsh   +1 more
wiley   +1 more source

No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older

, 2010
Background The bovine spongiform encephalopathy (BSE) epidemic presented homogeneity of the phenotype. This classical BSE (called C-type) was probably due to the contamination of the food chain by a single prion strain.
van Keulen Lucien, Rodeghiero Caroline, Caroline Rodeghiero, S. Durand, Dobly Alexandre, Alexandre Dobly, Roels, S., Emmanuel Vanopdenbosch, A. Dobly, Sloovere, J., de, Jessica De Sloovere, Patrick Van Muylem, van Muylem, P., Van Muylem Patrick, Langeveld Jan, Keulen, L.J.M., van, van Keulen, L.J.M., Stefan Roels, Vanopdenbosch, E., J. De Sloovere, Dobly, A., Langeveld, J.P.M., Geeroms Riet, Vanopdenbosch Emmanuel, Lucien van Keulen, P. Van Muylem, Muylem, P., van, Jan Langeveld, de Sloovere, J., Rodeghiero, C., Stéphanie Durand, Roels Stefan, Durand Stéphanie, De Sloovere Jessica, L. van Keulen, Geeroms, R., C. Rodeghiero, R. Geeroms, Durand, S.V.M., J. Langeveld, S. Roels, E. Vanopdenbosch, Riet Geeroms   +42 more
core   +1 more source

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD [PDF]

, 2011
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the ...
Smith, Antony, Ian R. MacGregor, Groschup, Martin H., Hunter, N., Hunter, Nora, Prowse, C.V., Tan, B.C., Hornsey, V.S., Boon Chin Tan, Sandra McCutcheon, Jean C Manson, Antony Smith, E. Fiona Houston, Jean C. Manson, Alejo-Blanco, Richard, Manson, J.C., Tan, Boon Chin, Turner Marc, Manson, Jean C., Houston E. Fiona, Alejo Blanco, A.R., Turner, Marc, Groschup Martin H., MacGregor, Ian R., Houston, Fiona, Christopher V Prowse, Turner, M., E Fiona Houston, Alejo Blanco Anthony Richard, Groschup, M.H., Martin H Groschup, Smith Antony, de Wolf, C., Christopher V. Prowse, Hunter Nora, Prowse, Christopher V., Christopher de Wolf, Anthony Richard Alejo Blanco, MacGregor Ian R., de Wolf Christopher, Marc Turner, de Wolf, Christopher, Valerie S. Hornsey, Smith, A., Manson Jean C., Prowse Christopher V., Ian R MacGregor, Prowse, C. V., Hornsey, Valerie S., McCutcheon Sandra, MacGregor, I.R., McCutcheon, Sandra, Nora Hunter, Tan Boon Chin, Hornsey Valerie S., Martin H. Groschup, McCutcheon, S., Houston, E.F., Valerie S Hornsey   +58 more
core   +1 more source

Defensins: The Case for Their Use against Mycobacterial Infections

Journal of Immunology Research, 2016
Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial
Haodi Dong, Yue Lv, Deming Zhao, Paul Barrow, Xiangmei Zhou   +4 more
doaj   +1 more source

RT-QuIC detection of pathological prion protein in subclinical goats following experimental oral transmission of L-type BSE

BMC Research Notes, 2021
Objective The spread of bovine spongiform encephalopathy (BSE) agent to small ruminants is still a major issue in the surveillance of transmissible spongiform encephalopathies (TSEs). L-type bovine spongiform encephalopathy (L-BSE) is an atypical form of
Alessandra Favole, Maria Mazza, Antonio D’Angelo, Guerino Lombardi, Claudia Palmitessa, Luana Dell’Atti, Giulia Cagnotti, Elena Berrone, Marina Gallo, Tiziana Avanzato, Erika Messana, Loretta Masoero, Pier Luigi Acutis, Daniela Meloni, Franco Cardone, Maria Caramelli, Cristina Casalone, Cristiano Corona   +17 more
doaj   +1 more source