Results 21 to 30 of about 4,885 (171)

Implications of gut microbiota dysbiosis and metabolic changes in prion disease

Neurobiology of Disease, 2020
Evidence of the gut microbiota influencing neurodegenerative diseases has been reported for several neural diseases. However, there is little insight regarding the relationship between the gut microbiota and prion disease. Here, using fecal samples of 12
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang   +12 more
doaj   +1 more source

Immunoregulatory and Antimicrobial Activity of Bovine Neutrophil β-Defensin-5-Loaded PLGA Nanoparticles against Mycobacterium bovis

Pharmaceutics, 2020
Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis complex imposing a high zoonotic threat to human health. The limited efficacy of BCG (Bacillus Calmette–Guérin) and upsurges of drug-resistant tuberculosis require new effective
Zhengmin Liang, Yiduo Liu, Xingya Sun, Jingjun Lin, Jiao Yao, Yinjuan Song, Miaoxuan Li, Tianlong Liu, Xiangmei Zhou   +8 more
doaj   +1 more source

Transmissible Spongiform Encephalopathies

New England Journal of Medicine, 1997
The transmissible spongiform encephalopathies are caused by infectious agents but usually present as genetic or sporadic disorders. The nature of the infectious agents is not known. In 1986 a new transmissible spongiform encephalopathy, which was called bovine spongiform encephalopathy or “mad cow disease,” was described in Britain.1 In 1996 the ...
V, Moennig, J, Fritzemeier
  +7 more sources

Effects of Flaxseed and Multi-Carbohydrase Enzymes on the Cecal Microbiota and Liver Inflammation of Laying Hens

Animals, 2021
Background: The use of wheat and flaxseed to produce omega-3 (ω-3) enriched poultry meat and eggs is very popular in the world. However, wheat and flaxseed contain some anti-nutritional factors (ANFs), and enzymes are usually used to alleviate the ...
Mazhar Hussain Mangi, Tariq Hussain, Muhammad Suhaib Shahid, Naveed Sabir, Muhammad Saleem Kalhoro, Xiangmei Zhou, Jianmin Yuan   +6 more
doaj   +1 more source

Experimental Bovine Spongiform Encephalopathy in Squirrel Monkeys: The Same Complex Proteinopathy Appearing after Very Different Incubation Times

Pathogens, 2022
Incubation periods in humans infected with transmissible spongiform encephalopathy (TSE) agents can exceed 50 years. In humans infected with bovine spongiform encephalopathy (BSE) agents, the effects of a “species barrier,” often observed when TSE ...
Pedro Piccardo, Juraj Cervenak, Wilfred Goldmann, Paula Stewart, Kitty L. Pomeroy, Luisa Gregori, Oksana Yakovleva, David M. Asher   +7 more
doaj   +1 more source

Detection of Cell-Free Mitochondrial DNA in Cerebrospinal Fluid of Creutzfeldt-Jakob Patients

Frontiers in Neurology, 2019
Background: The current diagnosis method for Creutzfeldt-Jakob disease (CJD) is post-mortem examination, so early detection of CJD has been historically problematic. Auxiliary detection of CJD based on changes in levels of components of the cerebrospinal
Jie Li, Yuhan Duan, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Xixi Zhang, Mengyu Lai, Zhiling Guan, Dongming Yang, Xiaoqian Wu, Hongli Gao, Huafen Zhao, Qi Shi, Lifeng Yang   +13 more
doaj   +1 more source

The Transmissible Spongiform Encephalopathies of Livestock [PDF]

ILAR Journal, 2015
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal protein-misfolding neurodegenerative diseases. TSEs have been described in several species, including bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, chronic wasting disease (CWD) in cervids, transmissible mink encephalopathy (TME) in mink, and ...
Justin J, Greenlee, M Heather West, Greenlee   +1 more
openaire   +2 more sources

Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis

Cells, 2019
Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases.
Naveed Sabir, Tariq Hussain, Yi Liao, Jie Wang, Yinjuan Song, Muhammad Shahid, Guangyu Cheng, Mazhar Hussain Mangi, Jiao Yao, Lifeng Yang, Deming Zhao, Xiangmei Zhou   +11 more
doaj   +1 more source

Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling

Frontiers in Microbiology, 2020
Mycobacterium bovis is the causative agent of bovine tuberculosis, has been identified a serious threat to human population. It has been found that sodium butyrate (NaB), the inhibitor of histone deacetylase, can promote the expression of cathelicidin ...
Kai Zhang, Tariq Hussain, Tariq Hussain, Jie Wang, Mengying Li, Wenjia Wang, Xiaojing Ma, Yi Liao, Jiao Yao, Yinjuan Song, Zhengmin Liang, Xiangmei Zhou, Lihua Xu   +12 more
doaj   +1 more source

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection

BMC Infectious Diseases, 2019
Background Mycobacterium bovis (M. bovis) is the principal causative agent of bovine tuberculosis; however, it may also cause serious infection in human being.
Jie Wang, Tariq Hussain, Kai Zhang, Yi Liao, Jiao Yao, Yinjuan Song, Naveed Sabir, Guangyu Cheng, Haodi Dong, Miaoxuan Li, Jiamin Ni, Mazhar Hussain Mangi, Deming Zhao, Xiangmei Zhou   +13 more
doaj   +1 more source