Results 21 to 30 of about 6,019 (214)

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Frontiers in Neurology, 2019
It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis.
Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Lifeng Yang   +12 more
doaj   +1 more source

The Spectrum of Transmissible Spongiform Encephalopathies

Intervirology, 1997
Since the first description by A.M. Jakob and H.G. Creutzfeldt, five human diseases have been identified as transmissible spongiform encephalopathies (TSE). The disease bearing these authors' name, Creutzfeldt-Jakob disease (CJD) occurs sporadically, may be transmitted and has a genetic basis in 10-15% of all cases.
Weber, T, Aguzzi, A
openaire   +2 more sources

State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology [PDF]

, 2009
Scrapie is a fatal, neurodegenerative disease of sheep and goats. It is also the earliest known member in the family of diseases classified as transmissible spongiform encephalopathies (TSE) or prion diseases, which includes Creutzfeldt-Jakob disease in ...
Olivier Andreéoletti, Groschup, Martin H., Simone Peletto, Foster, James, Barillet, F., Acin, Cristina, Pierluigi Acutis, Peletto, S., Langeveld, J., Theodoros Sklaviadis, Keulen, L.J.M., van, Bossers, Alex, Vaccari, G., Van Keulen, Lucien, Foster, J., Acin, C., Cristina Acin, Andreoletti, O., Jan Langeveld, Goldmann, Wilfred, Umberto Agrimi, Sklaviadis, T., Vaccari, Gabriele, Langeveld, Jan, van Keulen, L., Groschup, M.H., Peletto, Simone, Bossers, A., Gabriele Vaccari, James Foster, Panagiotidis, C.H., Cynthia H. Panagiotidis, Alex Bossers, Badiola, J. J., Badiola, J.J., van Keulen, L.J.M., Juan J. Badiola, Francis Barillet, Sklaviadis, Theodoros, Barillet, Francis, Langeveld, J.P.M., Wilfred Goldmann, Panagiotidis, Cynthia H., Acutis, Pierluigi, Andreeoletti, O., Badiola, Juan J., Goldmann, W., Panagiotidis, C. H., Groschup, M. H., Andreoletti, Olivier, Acutis, P., Agrimi, Umberto, Lucien Van Keulen, Martin H. Groschup, Agrimi, U.   +54 more
core   +1 more source

Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. [PDF]

, 2010
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. To date, the disease process is still poorly understood.
Xiang, Wei, Hans A. Kretzschmar, Hans A Kretzschmar, Kretzschmar, Hans A., Yue Tang, Otto Windl, Terry, Linda, Windl, Otto, Tang, Yue, Linda Terry, Wei Xiang   +10 more
core   +1 more source

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Frontiers in Immunology, 2019
Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages and induces endoplasmic reticulum stress (ERS), mitochondrial damage, and interleukin (IL)-1β production. The relationship between these phenotypes is
Yi Liao, Tariq Hussain, Chunfa Liu, Yongyong Cui, Jie Wang, Jiao Yao, Hehua Chen, Yinjuan Song, Naveed Sabir, Mazhar Hussain, Deming Zhao, Xiangmei Zhou   +11 more
doaj   +1 more source

MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 Binding Protein 2

Frontiers in Immunology, 2018
Mycobacterium avium subspecies paratuberculosis (MAP) persistently survive and replicate in mononuclear phagocytic cells by adopting various strategies to subvert host immune response.
Tariq Hussain, Deming Zhao, Syed Zahid Ali Shah, Jie Wang, Ruichao Yue, Yi Liao, Naveed Sabir, Lifeng Yang, Xiangmei Zhou   +8 more
doaj   +1 more source

Pruritus is a common feature in sheep infected with the BSE agent. [PDF]

, 2008
BACKGROUND: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain ...
Vidal-Diez, Alberto, Chaplin, Melanie J., Simmons, MM, Marion M Simmons, Chaplin, Melani J., Dexter, Glenda, Vidal-Diez, A, Martin Jeffrey, Christine Berthelin-Baker, Bone Gemma, Melanie J Chaplin, Glenda Dexter, Konold Timm, Tortosa Méndez, Raül, Peter Hill, Simmons Marion M, Simmons, Marion M., Tortosa Raul, Chaplin Melanie J, Davis Andrew, Berthelin-Baker, C, Bellworthy, SJ, Dexter Glenda, Bellworthy Susan J, Chaplin, MJ, Susan J Bellworthy, Bellworthy, Susan J., Timm Konold, Hill, P, Berthelin-Baker Christine, Gemma Bone, Raul Tortosa, Tortosa, R, Vidal-Diez Alberto, Jeffrey Martin, Hill, Peter, Konold, T, Hill Peter, Tortosa, Raul, Berthelin-Baker, Christine, Dexter, G, Davis, Andrew, Bone, G, Davis, A, Vidal Díez, Alberto, Jeffrey, M, Bone, Gemma, Jeffrey, Martin, Konold, Timm, Andrew Davis, Alberto Vidal-Diez   +50 more
core   +1 more source

Possible alignment of the EU BSE surveillance with the new WOAH provisions. [PDF]

EFSA J
Abstract The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C‐, H‐ and L‐type) in the European Union (EU) and to propose if any current EU surveillance provisions should be kept.
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Alvarez J, Boklund A, Dippel S, Dórea F, Figuerola J, Herskin MS, Michel V, Miranda Chueca MA, Nannoni E, Riber AB, Stahl K, Stegeman JA, Thulke HH, Tuyttens F, Winckler C, Arnold M, Ducrot C, Griffin J, Ru G, Simmons M, Ashe S, Pelaez AO, Kryemadhi K, Nonno R.   +25 more
europepmc   +2 more sources

MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in
Jie Wang, Tariq Hussain, Ruichao Yue, Yi Liao, Qiang Li, Jiao Yao, Yinjuan Song, Xin Sun, Nan Wang, Lei Xu, Srinand Sreevatsan, Deming Zhao, Xiangmei Zhou   +12 more
doaj   +1 more source

BSE infectivity in jejunum, ileum and ileocaecal junction of incubating cattle [PDF]

, 2011
To establish bovine spongiform encephalopathy (BSE) public health protection measures it is important to precisely define the cattle tissues considered as specified risk materials (SRM).
Rogers Ron, Ziegler Ute, Ziegler, U., Groschup, Martin H., Keller, M., van Keulen Lucien, Eiden, M., Hoffmann Christine, Eiden, Martin, Keller Markus, Eiden Martin, Bob Hills, Hills Bob, Christine Hoffmann, Jorg G Jacobs, Balkema-Buschmann, A., Van Keulen, L., Martin Kaatz, Ziegler, Ute, Ute Ziegler, Keulen, L., Van, Jacobs, J.G., Balkema-Buschmann Anne, Rogers, R., Keller, Markus, Groschup Martin H, Hoffmann, C., Hills, B., Lucien van Keulen, Balkema-Buschmann, Anne, Markus Keller, Martin Eiden, Kaatz, Martin, Fast, Christine, Anne Balkema-Buschmann, Kaatz Martin, Groschup, M.H., Martin H Groschup, Jacobs Jorg G, Kaatz, M., Ron Rogers   +40 more
core   +1 more source