Results 21 to 30 of about 10,379,704 (316)

Swine-to-Ferret Transmission of Antigenically Drifted Contemporary Swine H3N2 Influenza A Virus Is an Indicator of Zoonotic Risk to Humans

open access: yesViruses, 2023
Human-to-swine transmission of influenza A (H3N2) virus occurs repeatedly and plays a critical role in swine influenza A virus (IAV) evolution and diversity. Human seasonal H3 IAVs were introduced from human-to-swine in the 1990s in the United States and
Carine K. Souza   +10 more
doaj   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

open access: yes, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C   +9 more
core   +1 more source

Genetic and Antigenic Characterization of an Expanding H3 Influenza A Virus Clade in U.S. Swine Visualized by Nextstrain

open access: yesmSphere, 2022
Defining factors that influence spatial and temporal patterns of influenza A virus (IAV) is essential to inform vaccine strain selection and strategies to reduce the spread of potentially zoonotic swine-origin IAV.
Megan N. Neveau   +6 more
doaj   +1 more source

Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC

open access: yesBMC Research Notes, 2018
Objective Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrPC) into a pathogenic form (PrPSc) that ...
Soyoun Hwang   +3 more
doaj   +1 more source

Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ

open access: yesBMC Veterinary Research, 2020
Background Transmissible mink encephalopathy (TME) is a fatal neurologic disease of farmed mink. Evidence indicates that TME and L-BSE are similar and may be linked in some outbreaks of TME.
Eric Cassmann   +6 more
doaj   +1 more source

Cellular and Molecular Mechanisms of Prion Disease.

open access: yesAnnual Review of Pathology, 2019
Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by misfolded, aggregated proteins known as prions, which are uniquely infectious.
C. Sigurdson, Jason C. Bartz, M. Glatzel
semanticscholar   +1 more source

Expression Pattern of a Mini Human PrP Gene Promoter in Transgenic Mice

open access: yesNeurobiology of Disease, 2002
The prion protein is central to the pathogenesis of prion diseases, although its exact function remains unclear. Although transgenic mice have been widely utilised in prion research, their PrP expression patterns have not been characterised in detail. We
E.A. Asante   +4 more
doaj   +1 more source

ISU FLUture: a veterinary diagnostic laboratory web-based platform to monitor the temporal genetic patterns of Influenza A virus in swine

open access: yesBMC Bioinformatics, 2018
Background Influenza A Virus (IAV) causes respiratory disease in swine and is a zoonotic pathogen. Uncontrolled IAV in swine herds not only affects animal health, it also impacts production through increased costs associated with treatment and prevention
Michael A Zeller   +4 more
doaj   +1 more source

Prion Diseases [PDF]

open access: yesSeminars in Neurology, 2012
Prion diseases are a group of diseases caused by abnormally conformed infectious proteins, called prions. They can be sporadic (Jakob-Creutzfeldt disease [JCD]), genetic (genetic JCD, Gerstmann-Sträussler-Scheinker, and familial fatal insomnia), or acquired (kuru, variant JCD, and iatrogenic JCD).
Takada, Leonel, Geschwind, Michael
openaire   +4 more sources

Recent advances in the histo‐molecular pathology of human prion disease

open access: yesBrain Pathology, 2019
Prion diseases are progressive neurodegenerative disorders affecting humans and other mammalian species. The term prion, originally put forward to propose the concept that a protein could be infectious, refers to PrPSc, a misfolded isoform of the ...
Simone Baiardi   +3 more
semanticscholar   +1 more source

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