Results 111 to 120 of about 2,165,687 (231)

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrPres [PDF]

, 2006
Prion diseases are associated with the conversion of the normal cellular prion protein, PrPC, to the abnormal, disease-associated form, PrPSc. This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that
Kirby, Louise, Manson, Jean C., Houston, Fiona, Goldmann, Wilfred, Gill, Andrew C.   +4 more
core   +1 more source

Prions, prion-like prionoids, and neurodegenerative disordersVacancy

Annals of Indian Academy of Neurology, 2016
Prion diseases or transmissible spongiform encephalopathies are fatal neurodegenerative diseases characterized by the aggregation and deposition of the misfolded prion protein in the brain.
Ashok Verma
doaj   +1 more source

Space and resource use by American crow Corvus brachyrhynchos in an area endemic for chronic wasting disease

Wildlife Biology, EarlyView.
American crow Corvus brachyrhynchos is a common species throughout North America. Crows play a role in the ecology of multiple diseases and a single laboratory experiment has shown the potential for crows to pass infectious prions, such as those associated with chronic wasting disease (CWD), in their feces after being force‐fed with infected material ...
Tyler S. Walters, Kurt C. VerCauteren, W. David Walter   +2 more
wiley   +1 more source

Perceived Risks and Agency Trust Associated With Chronic Wasting Disease Over Time 慢性消耗性疾病相关感知风险与机构信任的时序变化研究

Wildlife Letters, EarlyView.
We examined changes in perceived risks associated with chronic wasting disease (CWD) and perceived trust in wildlife agencies over time across 10 studies in eight states. Results indicated that perceived risks to both deer and humans declined the longer the disease had been in a state. Results also indicated that agency trust evaluations were positive,
Jerry J. Vaske, Craig A. Miller
wiley   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core   +1 more source

Wild pigs (Sus scrofa) prefer inoculated peanuts over whole‐kernel corn in cafeteria‐style study

Wildlife Society Bulletin, EarlyView.
In this study, we explored bait preference of wild pigs (Sus scrofa), a highly invasive species where primary removal efforts include the use of bait and corral‐style trapping. In addition, we investigated preferences of a common nontarget to identify a bait that is preferred by wild pigs and not by white‐tailed deer (Odocoileus virginianus).
Justine L. Smith, Michael T. Mengak, David A. Sisson, T. Scott Smith, Gino J. D'Angelo, L. Mike Conner   +5 more
wiley   +1 more source

Therapeutic effect of curcumin derivative GT863 on prion-infected mice

Scientific Reports
In prion diseases, the cellular prion protein (PrPC) forms an abnormal, infectious, and disease-causing form known as PrPSc. Inhibition of prion propagation is a key approach for the treatment of these diseases.
Kenta Teruya, Ayumi Oguma, Michiaki Okuda, Sara Iwabuchi, Hiroyuki Konno, Hiroyuki Arai, Yukitsuka Kudo, Hachiro Sugimoto, Katsumi Doh-ura   +8 more
doaj   +1 more source

Predicting disease spread from host movement data: Chronic wasting disease in North America as a case study

Journal of Animal Ecology, EarlyView.
This paper estimates the rate of chronic wasting disease spread in multiple regions and compares these rates with model predictions based on deer movement data. Abstract Rare long‐distance movements can increase the spatial spread of invasive species and shifts in species ranges. For wildlife disease spread, however, seasonal migrations may only matter
Paul C. Cross, Blake Lowrey, Matthew Kauffman, Evelyn Merrill   +3 more
wiley   +1 more source

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source