Results 151 to 160 of about 5,604,422 (355)

Label‐Free Detection of π‐Stacking Interactions During Tryptophan Self‐Assembling Into Amyloid‐Like Structures Using Surface‐Enhanced Raman Scattering

Journal of Raman Spectroscopy, EarlyView.
Tryptophan (Trp) self‐assembling into amyloid‐like fibrils was characterized for the first time with surface‐enhanced Raman scattering (SERS). It was possible to identify several spectral characteristics of the self‐assembled structures. This allowed to detect and monitor, as function of time, of several intermolecular interactions such as hydrogen ...
Gabriel Conishi Cardozo, Evandro Luiz Duarte, Antonio Rodrigues da Cunha, Diogo Soga, Márcia de Almeida Rizzutto, M. Teresa Lamy, Erix Alexander Milán‐Garcés   +6 more
wiley   +1 more source

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

PLoS Pathogens, 2017
Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrPC is required for toxicity, suggesting the existence of deleterious PrPC-dependent signaling cascades.
Despoina Goniotaki, Asvin K K Lakkaraju, Amulya N Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi   +10 more
doaj   +1 more source

Integrity of H1 helix in prion protein revealed by molecular dynamic simulations to be especially vulnerable to changes in the relative orientation of H1 and its S1 flank

, 2009
In the template-assistance model, normal prion protein (PrPC), the pathogenic cause of prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrPSc ...
A Aguzzi, A Aguzzi, A Barducci, A Onufriev, C Guilbert, Chih-Yuan Tseng, Chun-Ping Yu, DA Case, DA Harris, E Lindahl, E Malolepsza, F Eghiaian, GJ Sharman, GS Jackson, H. C. Lee, HJC Berendsen, J Castilla, J Watzlawik, J Ziegler, JP Ryckaert, KM Pan, L Calzolai, M Horiuchi, ML DeMarco, ML DeMarco, MP Morrissey, N Guex, P Derreumaux, P Tompa, R Riek, RI Dima, S Megy, S Santini, S Santini, SA Kozin, SB Prusiner, T Muramoto, W Kabsch, WQ Zou, Y Levy, Y Levy   +40 more
core   +1 more source

Primary structure of prion protein may modify scrapie isolate properties. [PDF]

, 1989
George A. Carlson, David Westaway, S. J. DeArmond, M Peterson-Torchia, Stanley B. Prusiner   +4 more
openalex   +1 more source

α-Cleavage of cellular prion protein

Prion, 2012
The cellular prion protein (PrPC) is subjected to various processing under physiological and pathological conditions, of which the α-cleavage within the central hydrophobic domain not only disrupts a region critical for both PrP toxicity and PrPC to ...
Jingjing Liang, Qingzhong Kong
semanticscholar   +1 more source

Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4‐repeat τ pathology, which is thought to propagate across interconnected neurons. Objectives We hypothesized that interconnected brain regions exhibit correlated atrophy, and that atrophy propagates network‐like from fast‐declining epicenters to connected
Carla Palleis, Andrea Quattrone, Amir Dehsarvi, Sebastian N. Roemer‐Cassiano, Alexander M. Bernhardt, The AL‐108‐231 Investigators, the PASSPORT Study Group, Ikuko Aiba, Angelo Antonini, Diana Apetauerova, Jean‐Philippe Azulay, Ernest Balaguer Martinez, Jee Bang, Paolo Barone, Matthew Barrett, Danny Bega, Daniela Berg, Koldo Berganzo Corrales, Yvette Bordelon, Adam L Boxer, Moritz Brandt, Norbert Brueggemann, Giovanni Castelnovo, Roberto Ceravolo, Rosalind Chuang, Sun Ju Chung, Alistair Church, Jean‐Christophe Corvol, Paola Cudia, Marian Dale, Luc Defebvre, Sophie Drapier, Erika D Driver‐Dunckley, Georg Ebersbach, Karla M Eggert, Aaron Ellenbogen, Alexandre Eusebio, Andrew H Evans, Natalia Fedorova, Elizabeth Finger, Alexandra Foubert‐Samier, Boyd Ghosh, Lawrence Golbe, Francisco Grandas Perez, Murray Grossman, Deborah Hall, Kyoko Hamada, Kazuko Hasegawa, Guenter Hoeglinger, Lawrence Honig, David Houghton, Xuemei Huang, Stuart Isaacson, Jaime Kulisevsky Bojarski, Anthony E. Lang, Peter Nigel Leigh, Biomedical Research, Irene Litvan, Juan Jose Lopez Lozano, Jose Luis Lopez‐Sendon Moreno, Albert Christian Ludolph, Ma Rosario Luquin Piudo, Irene Martinez Torres, Nikolaus McFarland, Wassilios Meissner, Tiago Mestre, Pablo Mir Rivera, Eric Molho, Britt Mollenhauer, Huw R Morris, Miho Murata, Tomokazu Obi, Fabienne Ory Magne, Padraig O'Suilleabhain, Rajesh Pahwa, Alexander Pantelyat, Nicola Pavese, Dmitry Pokhabov, Johannes Prudlo, Federico Rodriguez‐Porcel, James Rowe, Joseph Savitt, Alfons Schnitzler, Joerg B Schulz, Klaus Seppi, Binit Shah, Holly Shill, David Shprecher, Maria Stamelou, Malcolm Steiger, Yuji Takahashi, Hiroshi Takigawa, Carmela Tartaglia, Lars Toenges, Kardiologische Studienambulanz, Daniel Truong, Winona Tse, Paul Tuite, Dieter Volc, Anne‐Marie A Wills, Dirk Woitalla, Tao Xie, Tatsuhiko Yuasa, Sarah Elizabeth Zauber, Theresa Zesiewicz, David Williams, Anne Louise Lafontaine, Connie Marras, Mandar Jog, Michael Panisset, Anthony Lang, Lesley Parker, Alistair J. Stewart, Jean‐Christophe Corvol, Jean‐Philippe Azulay, Philippe Couratier, Brit Mollenhauer, Stefan Lorenzl, Albert Ludolph, Reiner Benecke, Günter Höglinger, Axel Lipp, Heinz Reichmann, Dirk Woitalla, Dennis Chan, Adam Zermansky, David Burn, Andrew Lees, Adam Boxer, Bruce L. Miller, Iryna V. Lobach, Erik Roberson, Lawrence Honig, Edward Zamrini, Rajesh Pahwa, Yvette Bor‐delon, Erika Driver‐Dunkley, Stephanie Lessig, Mark Lew, Kyle Womack, Brad Boeve, Joseph Ferrara, Argyle Hillis, Daniel Kaufer, Rajeev Kumar, Tao Xie, Steven Gunzler, Theresa Zesiewicz, Praveen Dayalu, Lawrence Golbe, Murray Grossman, Joseph Jancovic, Scott McGinnis, Anthony Santiago, Paul Tuite, Stuart Isaacson, Julie Leegwater‐Kim, Irene Litvan, Murray Grossman, David S. Knopman, Bruce L. Miller, Lon S. Schneider, Rachelle S. Doody, Lawrence I. Golbe, Erik D. Roberson, Mary Koestler, Clifford R. Jack, Viviana Van Deerlin, Christopher Randolph, Iryna V. Lobach, Illana Gozes, Steve Whitaker, Joe Hirman, Michael Gold, Bruce H. Morimoto, Hans‐Jürgen Huppertz, Maura Malpetti, Adam L. Boxer, Johannes Gnörich, Lukas Frontzkowski, Johannes Levin, Matthias Brendel, Günter U. Höglinger, Nicolai Franzmeier   +183 more
wiley   +1 more source

Efficient transmission and characterization of creutzfeldt-jakob disease strains in bank voles.

PLoS Pathogens, 2006
Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model.
Romolo Nonno, Michele A Di Bari, Franco Cardone, Gabriele Vaccari, Paola Fazzi, Giacomo Dell'Omo, Claudia Cartoni, Loredana Ingrosso, Aileen Boyle, Roberta Galeno, Marco Sbriccoli, Hans-Peter Lipp, Moira Bruce, Maurizio Pocchiari, Umberto Agrimi   +14 more
doaj   +2 more sources

Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. [PDF]

, 1993
Marı́a Gasset, M. A. Baldwin, Robert J. Fletterick, Stanley B. Prusiner   +3 more
openalex   +1 more source

Mapping the Beta-Sheet Structure of the Yeast Prion Sup35 through Creation of Targeted Mutant Forms [PDF]

, 2013
Proteins with an aggregated form rich in beta-sheet structure are known as amyloids, of which a subset are infectious. These infectious proteins are known as prions and cause diseases including bovine spongiform encephalopathy (“Mad Cow” disease ...
Davis, Emily K., Knox, James D., Palacios, Daniel   +2 more
core   +1 more source

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source