Results 171 to 180 of about 5,604,422 (355)

Targeting of the prion protein to the cytosol: mechanisms and consequences

, 2010
Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M., Rambold, A., Tatzelt, J., Winkelhofer, K.   +3 more
core  

Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein

Brain Pathology, EarlyView.
This study investigated whether brain regions with distinct predominance of α‐synuclein (αSyn) cytopathologies show different αSyn seeding patterns in multiple system atrophy (MSA) and Lewy body disease (LBD), using an interdisciplinary approach. High seeding activity is observed in regions with oligodendrocytic‐predominant αSyn pathology in MSA.
Ain Kim, Ivan Martinez‐Valbuena, Krisztina Danics, Shelley L. Forrest, Gabor G. Kovacs   +4 more
wiley   +1 more source

Not So Smooth Sailing: FIG4‐Related Disease Is a Differential Diagnosis of Rapid Onset Dystonia‐Parkinsonism

Movement Disorders Clinical Practice, EarlyView.
Matthew Julian Georgiades, Duncan Wilson, Maria Garcia, Robert Boland‐Freitas, Hugo Morales‐Briceño, Neil Mahant, Victor Shue Chung Fung, Andrew Martin   +7 more
wiley   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

First Report of Single Nucleotide Polymorphisms (SNPs) of the Leporine Shadow of Prion Protein Gene (SPRN) and Absence of Nonsynonymous SNPs in the Open Reading Frame (ORF) in Rabbits

Animals
Prion disorders are fatal infectious diseases that are caused by a buildup of pathogenic prion protein (PrPSc) in susceptible mammals. According to new findings, the shadow of prion protein (Sho) encoded by the shadow of prion protein gene (SPRN) is ...
Sameeullah Memon, Zerui Wang, Wen-Quan Zou, Yong-Chan Kim, Byung-Hoon Jeong   +4 more
doaj   +1 more source

Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible [PDF]

, 1997
David G. Donne, John H. Viles, Darlene Groth, Ingrid Mehlhorn, Thomas Leroy James, Fred E. Cohen, Stanley B. Prusiner, Peter E. Wright, H. Jane Dyson   +8 more
openalex   +1 more source

Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition

, 2012
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating ...
Chen, Jie, Thirumalai, Devarajan
core   +1 more source

Alien Limb Phenomenon and Ideomotor Apraxia as Early Indicators of Sporadic Creutzfeldt‐Jakob Disease

Movement Disorders Clinical Practice, EarlyView.
Gero Lueg, Ilka Kleffner, Markus A. Hobert   +2 more
wiley   +1 more source

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1

Cancer Science, EarlyView.
Our study explores the potential of dauricine, a bioactive compound from Menispermum dauricum, to overcome osimertinib resistance in lung cancer. We demonstrate that dauricine, when combined with osimertinib, induces ferroptosis in resistant lung cancer cells by stabilizing SAT1, a key enzyme in oxidative stress regulation.
Biying Men, Zhijie Chen, Haotian Ge, Zhuoying Yang, Liang Yun, Jianjun Jiang, Meijuan Dian, Yujing He, Zehao Zhou, Ruihao Zhang, Tianbao Yan, Zichao Li, Yingxin Zhang, Yongjie He, Junming He, Xuguang Rao, Shuan Rao   +16 more
wiley   +1 more source

Normal prion protein has an activity like that of superoxide dismutase [PDF]

, 1999
David R. Brown, Boon‐Seng Wong, Farida Hafiz, Christine Clive, Stephen J. Haswell, Ian M. Jones   +5 more
openalex   +1 more source