Results 131 to 140 of about 5,269,629 (202)

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle.

PLoS Pathogens
In prion diseases (PrDs), aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Davide Caredio, Maruša Koderman, Karl J Frontzek, Silvia Sorce, Mario Nuvolone, Juliane Bremer, Giovanni Mariutti, Petra Schwarz, Lidia Madrigal, Marija Mitrovic, Stefano Sellitto, Nathalie Streichenberger, Claudia Scheckel, Adriano Aguzzi   +13 more
doaj   +1 more source

Genetic variability of the prion protein gene in Indonesian goat breeds. [PDF]

Trop Anim Health Prod, 2023
Pakpahan S, Widayanti R, Artama WT, Budisatria IGS, Lühken G.   +4 more
europepmc   +1 more source

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

Cell Biology International, Volume 50, Issue 9, September 2026.
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley   +1 more source

Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds. [PDF]

Vet Res, 2023
Sola D, Artigas R, Mediano DR, Zaragoza P, Badiola JJ, Martín-Burriel I, Acín C.   +6 more
europepmc   +1 more source

Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
DPMSCs‐derived exosomal PSMD1 stimulates M2 polarization through the JAK2/STAT3 pathway. DPMSCs‐derived exosomal PSMD1 indirectly acts on NE‐4C cells. DPMSCs‐derived exosomal PSMD1 ameliorates SCI in a mouse model. ABSTRACT Background Exosomes derived from mesenchymal stem cells (MSCs) and their cargo contribute to the protective properties of MSCs in ...
Xiaohui Xing, Yuan Hao, Guanghui Zhang, Xiaoyang Xing, Hongfei Jia, Chenlong Liu, Xin Wang, Tao Li, Xueyuan Li, Yilei Xiao   +9 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer. [PDF]

Prion, 2023
Pereira JC, Gonçalves-Anjo N, Orge L, Pires MA, Rocha S, Figueira L, Matos AC, Silva J, Mendonça P, Carvalho P, Tavares P, Lima C, Alves A, Esteves A, Pinto ML, Pires I, Gama A, Sargo R, Silva F, Seixas F, Vieira-Pinto M, Bastos E.   +21 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease

, 2010
Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction.
Perry, V. Hugh, O'Connor, Vincent, Asuni, Ayodeji A.   +2 more
core   +1 more source

Serial changes in regional cerebral blood flow in Gerstmann-Sträussler-Scheinker disease caused by a Pro-to-Leu mutation at codon 105 in the prion protein gene. [PDF]

Prion, 2023
Kawai H, Matsubayashi T, Yokota T, Sanjo N.   +3 more
europepmc   +1 more source