Results 151 to 160 of about 5,269,629 (202)

Proteína prion celular (PrPc) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em FarmacologiaO consumo de drogas com potencial aditivo, como o etanol, induz alterações sinápticas profundas na via mesocorticolímbica ...
Rial, Daniel
core  

Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi‐Derived Protocol Recommendations by the European Academy of Neurology

European Journal of Neurology, Volume 33, Issue 9, September 2026.
In the context of the Horizon Europe EBRAINS 2.0 research consortium, Delphi‐derived, consented protocol recommendations from European Academy of Neurology Scientific Panel experts provide a pragmatic framework for harmonizing multi‐scale data acquisition for connectome analyses in stroke, Parkinson's Disease, and glioma.
Thomas Berger, Lorenzo Pini, Alessandro Salvalaggio, Simone Cauzzo, Christine Klein, Maria Lolich, Alberto Picca, Dauren Ramankulov, Maria A. Rocca, Roberta Rudà, Alessandro Sodero, Alessandro Tessitore, Thomas Truelsen, Roland Wiest, Gereon R. Fink, Elena Moro, Philippe Ryvlin, Maurizio Corbetta   +17 more
wiley   +1 more source

Decontamination of prions, prion-associated amyloid and inefectivity from surgical stainless steel - implications for the risk of iatrogenic transmission of CJD

, 2009
The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core   +1 more source

Biochemical and Neuropathological Findings in a Creutzfeldt-Jakob Disease Patient with the Rare Val180Ile-129Val Haplotype in the Prion Protein Gene. [PDF]

Int J Mol Sci, 2022
Zanusso G, Colaizzo E, Poleggi A, Masullo C, Romeo R, Ferrari S, Bongianni M, Fiorini M, Tiple D, Vaianella L, Sbriccoli M, Porreca F, Equestre M, Pocchiari M, Cardone F, Ladogana A.   +15 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Genetic Polymorphism at 15 Codons of the Prion Protein Gene in 156 Goats from Romania. [PDF]

Genes (Basel), 2022
Gurau MR, Negru E, Ionescu T, Udriste AA, Cornea CP, Baraitareanu S.   +5 more
europepmc   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration

Traffic, Volume 27, Issue 3, September 2026.
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC‐derived neurons upstream of Tau accumulation. Pharmacological activation of autophagy activation reduces Tau burden without rescuing lysosome motility, revealing that trafficking and ...
Anaïs Bécot, Mehdi Kabani
wiley   +1 more source

Folding and fibril formation of prions [PDF]

Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
core  

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function. [PDF]

Sci Rep, 2022
Wood AR, Foliaki ST, Groveman BR, Walters RO, Williams K, Yuan J, Zou WQ, Haigh CL.   +7 more
europepmc   +1 more source