Results 141 to 150 of about 5,269,629 (202)
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley +1 more source
Elevated E200K Somatic Mutation of the Prion Protein Gene (PRNP) in the Brain Tissues of Patients with Sporadic Creutzfeldt-Jakob Disease (CJD). [PDF]
Won SY, Kim YC, Jeong BH.
europepmc +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu. [PDF]
Kim YC, Won SY, Jeong BH.
europepmc +1 more source
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji +6 more
wiley +1 more source
Creutzfeldt-Jakob disease associated with a T188K homozygous mutation in the prion protein gene: a case report and review of the literature. [PDF]
Shan Y +6 more
europepmc +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Prion protein gene mutation detection using long-read Nanopore sequencing. [PDF]
Kroll F +6 more
europepmc +1 more source
ABSTRACT The glucose repression system is a mechanism for effective energy acquisition by glucose assimilation in microorganisms. In yeast, Saccharomyces cerevisiae, which is known as a prion‐like protein [GAR+], is involved in the bypass of glucose repression. It has been reported that the emergence of [GAR+] cells was promoted by lactate and acetate.
Koichi Tanabe +3 more
wiley +1 more source

