Results 11 to 20 of about 33,090 (271)
The First Meta-Analysis of the M129V Single-Nucleotide Polymorphism (SNP) of the Prion Protein Gene (PRNP) with Sporadic Creutzfeldt–Jakob Disease [PDF]
Cells, 2021 Prion diseases are fatal, chronic, and incurable neurodegenerative diseases caused by pathogenic forms of prion protein (PrPSc) derived from endogenous forms of prion protein (PrPC).
Yong-Chan Kim, Byung-Hoon Jeong
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Prion protein gene in Alzheimer's disease [PDF]
Arquivos de Neuro-Psiquiatria, 2013 Alzheimer’s disease (AD) is a complex disorder, including sporadic (representing the majority of cases) and familial forms, the latter being usually linked to a genetic etiology. Three major genes have been already described as the cause of AD: amyloid precursor protein (APP) gene, presenilin 1 gene (PSEN1), and presenilin 2 gene (PSEN2), typically ...
Paulo Caramelli
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Polymorphism of prion protein gene (PRNP) in Nigerian sheep. [PDF]
Prion, 2023 Polymorphism of the prion protein gene (PRNP) gene determines an animal's susceptibility to scrapie. Three polymorphisms at codons 136, 154, and 171 have been linked to classical scrapie susceptibility, although many variants of PRNP have been reported.
Adeola AC +22 more
europepmc +4 more sources
Frontiers in Veterinary ScienceBackgroundNatural cases of prion disease have not been reported in rabbits, and prior attempts to identify a prion conversion agent have been unsuccessful. However, recent applications of prion seed amplifying experimental techniques have sparked renewed
Min-Ju Jeong +4 more
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Prions: proteins as genes and infectious entities [PDF]
Genes & Development, 2004 Infectious proteins (prions) include the transmissible spongiform encephalopathies (TSEs) of mammals, the amyloidoses [URE3], [PSI], and [PIN] of Saccharomyces cerevisiae and [Het-s] of the filamentous fungus Podospora anserina, and the self-activating in trans vacuolar protease B of yeast, called [ ].
Reed B, Wickner +6 more
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Frontiers in Veterinary Science, 2022 Prion diseases are irreversible neurodegenerative disorders caused by the aggregated form of prion protein (PrPSc) derived from the normal form of prion protein (PrPC).
Yong-Chan Kim +5 more
doaj +1 more source
Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds. [PDF]
Vet Res, 2023 AbstractPrion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrPC) into an abnormal and misfolded isoform known as PrPSc. Most prion diseases and their susceptibility and pathogenesis are mainly modulated by the PRNP gene that codes for PrP.
Sola D +6 more
europepmc +6 more sources
Animals, 2021 Prion disease is a fatal infectious disease caused by the accumulation of pathogenic prion protein (PrPSc) in several mammals. However, to date, prion disease has not been reported in horses.
Sae-Young Won +3 more
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PRION PROTEIN GENES IN CARIBOU FROM ALASKA [PDF]
Journal of Wildlife Diseases, 2007 Prion protein genes were sequenced in free-ranging Alaska caribou (Rangifer tarandus grantii). Caribou prion alleles are identical or nearly so to those of wapiti, white-tailed deer, and mule deer. Five single-nucleotide polymorphisms were detected with substitutions at residues 2 (V-->M), 129 (G-->S), 138 (S-->N), 146 (N-->N), and 169 (V-->M).
Happ, George M. +3 more
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Genetic aspects of human prion diseases
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
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