Results 191 to 200 of about 1,598,142 (264)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration

Traffic, Volume 27, Issue 3, September 2026.
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC‐derived neurons upstream of Tau accumulation. Pharmacological activation of autophagy activation reduces Tau burden without rescuing lysosome motility, revealing that trafficking and ...
Anaïs Bécot, Mehdi Kabani
wiley   +1 more source

Safety of Acheta domesticus (house cricket) spray‐dried powder as a Novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of a spray‐dried powder from house cricket (Acheta domesticus) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Thomas Frenzel, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Henk van Loveren, Areti Favata, Fernando Rivero‐Pino, Ermolaos Ververis, Karen Ildico Hirsch‐Ernst   +25 more
wiley   +1 more source

Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35. [PDF]

Prion, 2019
Sergeeva AV, Sopova JV, Belashova TA, Siniukova VA, Chirinskaite AV, Galkin AP, Zadorsky SP.   +6 more
europepmc   +1 more source

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein. [PDF]

PLoS Pathog
Amano G, Arshad H, Patel Z, Schmitt-Ulms G, Watts JC.   +4 more
europepmc   +1 more source

Deletion Analysis of Phase Separation, Amyloid Formation and Prion Propagation by the Intrinsically Disordered Region of Yeast Sup35 Protein. [PDF]

Int J Mol Sci
Grizel AV, Gorsheneva NA, Anee IJ, Paulius K, Kulichikhin KY, Rubel AA, Chernoff YO.   +6 more
europepmc   +1 more source

Piano-Stool Ru (II) Complexes as Modulators of Human Prion Protein PrP_106-126 Aggregation. [PDF]

ChemMedChem
Chauhan R, Kumawat H, Saini S, Panwar A, Kukreti P, Medda N, Roy P, Ghosh K.   +7 more
europepmc   +1 more source

Interaction of recombinant and disease-associated prion proteins with organic and mineral soil colloids [PDF]

, 2008
Russo, Fabio
core   +1 more source

Prion disease mimicking rapidly progressive Alzheimer disease: case series and systematic review. [PDF]

J Neurol
Elgenidi A, Shir D, Piura YD, Sokol LL, Duara R, Lachner C, Day GS.   +6 more
europepmc   +1 more source

Functional amyloids as molecular switches: emerging roles in diverse signalling pathways. [PDF]

Biochem Soc Trans
Buchanan JA, Williams BC, Steain M, Sunde M.   +3 more
europepmc   +1 more source