Results 231 to 240 of about 56,806 (329)

Hydrophobic residues in the α‐synuclein NAC domain drive seed‐competent fibril formation and are targeted by peptide inhibitors

The FEBS Journal, Volume 293, Issue 1, Page 134-155, January 2026.
The hydrophobic 68GAVV71 stretch in the NAC domain of α‐synuclein is essential for nucleation, while residues 79–95 are required for fibril stability and seeding. Truncation or inhibition of 68GAVV71 prevents fibril formation, and truncation of 79–95 abolishes seeding competency, highlighting their distinct roles in α‐synuclein aggregation and ...
Viswanath Das, Sayed Mostafa Modarres Mousavi, Narendran Annadurai, Sunčica Sukur, Faramarz Mehrnejad, Sajad Moradi, Lukáš Malina, Markéta Kolaříková, Vaclav Ranc, Ivo Frydrych, Roman Kouřil, Saman Hosseinkhani, Marián Hajdúch, Maryam Nikkhah   +13 more
wiley   +1 more source

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo. [PDF]

Acta Neuropathol
Hill E, Patel M, Ribes JM, Linehan J, Zhang F, Jakubcova T, Hamdan S, Tomlinson A, Ercolani T, Schmidt C, Ahmed P, Thirlway G, Argentina F, Marinho AT, Jones E, Kaye N, Fitzhugh C, Jackson GS, Brandner S, Kloehn P, Collinge J, Cunningham TJ, Mead S.   +22 more
europepmc   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination. [PDF]

Microbiol Spectr
Marín-Moreno A, Reine F, Jaffrézic F, Herzog L, Rezaei H, Quadrio I, Haïk S, Béringue V, Martin D.   +8 more
europepmc   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Addressing chronic wasting disease in Korean farms: topsoil removal and 2N NaOH treatment before cervid restocking. [PDF]

Prion
Park KJ, Park HC, Lee YR, Roh IS, Mitchell G, Choi YP, Sohn HJ.   +6 more
europepmc   +1 more source

Prion and Prion Diseases

, 2020
This review article provides the main information regarding a specific category of infectious diseases of animals and humans, the so-called transmissible spongiform encephalopathies, or prion infections. In a brief introduction explains the need for lighting issues in relation to environmental, veterinary public health importance in traffic and the ...
openaire   +1 more source

Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

, 2020
Natallia Makarava, Jennifer C. Chang, Kara Molesworth, Ilia V. Baskakov   +3 more
openalex   +1 more source

Academy calls for improved tests to beat prion disease [PDF]

, 2003
Jonathan Knight
openalex   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source