Results 31 to 40 of about 56,806 (329)

Efficient interspecies transmission of synthetic prions.

PLoS Pathogens, 2021
Prions are comprised solely of PrPSc, the misfolded self-propagating conformation of the cellular protein, PrPC. Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals.
Alyssa J Block, Ronald A Shikiya, Thomas E Eckland, Anthony E Kincaid, Ryan W Walters, Jiyan Ma, Jason C Bartz   +6 more
doaj   +1 more source

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]

, 2008
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano, Borkowski, Andrew W., Heppner, Frank L., Hutter, Gregor, Jackson, Walter S., King, Oliver D., Lindquist, Susan, Raymond, Gregory J., Steele, Andrew D.   +8 more
core   +3 more sources

Prions [PDF]

Proceedings of the National Academy of Sciences, 1984
Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
openaire   +3 more sources

Development of a methodology for large-scale production of prions for biological and structural studies

Frontiers in Molecular Biosciences, 2023
Prion diseases are a group of infectious neurodegenerative diseases produced by the conversion of the normal prion protein (PrPC) into the disease-associated form (PrPSc).
Luis Concha-Marambio, Luis Concha-Marambio, Fei Wang, Enrique Armijo, Damian Gorski, Frank Ramirez, Andrew Scowcroft, Sandra Pritzkow, Claudio Soto, Claudio Soto   +9 more
doaj   +1 more source

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie

Frontiers in Neuroscience, 2015
Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf, Andre eHossinger, Andrea eFehlinger, Sven eBuettner, Valerie eSim, Debbie eMcKenzie, Ina Maja Vorberg, Ina Maja Vorberg   +7 more
doaj   +1 more source

Resistance of soil-bound prions to rumen digestion. [PDF]

PLoS ONE, 2012
Before prion uptake and infection can occur in the lower gastrointestinal system, ingested prions are subjected to anaerobic digestion in the rumen of cervids and bovids.
Samuel E Saunders, Shannon L Bartelt-Hunt, Jason C Bartz   +2 more
doaj   +1 more source

Distinct amino acid compositional requirements for formation and maintenance of the [PSI+] prion in yeast [PDF]

, 2015
Multiple yeast prions have been identified that result from the structural conversion of proteins into a self-propagating amyloid form. Amyloid-based prion activity in yeast requires a series of discrete steps.
Ben-Musa, Zobaida, Gruca, Margaret, MacLea, Kyle S., Paul, Kacy R., Ross, Eric D., Shattuck, Jenifer E., Waechter, Aubrey   +6 more
core   +2 more sources

Cross infection control measures and the treatment of patients at risk of Creutzfeldt Jakob disease in UK general dental practice [PDF]

, 2001
AIMS: To determine the suitability of key infection control measures currently employed in UK dental practice for delivery of dental care to patients at risk of prion diseases.
A Smith, AF Hill, AF Hill, C P Sweeney, CM Van Duijn, DH Adams, DM Taylor, F Blanquet-Gossard, H Ashraf, IF Laurenson, J Bagg, K Arakawa, K M Roy, L Ingrosso, ME Bruce, R Dobson, RG Will, RG Will, RI Carp, RT Johnson, S Collins, T Sharp, Z Davanipour   +22 more
core   +1 more source

MicroRNAs and depression

Neurobiology of Disease, 2012
With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden.
Sophie Mouillet-Richard, Anne Baudry, Jean-Marie Launay, Odile Kellermann   +3 more
doaj   +1 more source

Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. [PDF]

PLoS ONE, 2017
In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion ...
Kohtaro Miyazawa, Kentaro Masujin, Hiroyuki Okada, Yuko Ushiki-Kaku, Yuichi Matsuura, Takashi Yokoyama   +5 more
doaj   +1 more source