Results 91 to 100 of about 8,300 (285)
Folding and fibril formation of prions [PDF]
Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
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Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis
Muscle &Nerve, EarlyView.ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick +4 more
wiley +1 more source
The 37kDa/67kDa laminin receptor as a therapeutic target in prion diseases: potency of antisense LRP RNA, siRNAs specific for LRP mRNA and a LRP decoy mutant [PDF]
, 2006 Prion diseases are a group of rare, fatal neurodegenerative diseases, also known as transmissible spongiform encephalopathies (TSEs), that affect both animals and humans and include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep ...
Vana, Karen
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Virology Journal, 2012 Background Transmissible spongiform encephalopathy (TSE) diseases are known to be zoonotic diseases that can infect different kinds of animals. The transmissibility of TSE, like that of other infectious diseases, shows marked species barrier, either ...
Shi Qi +7 more
doaj +1 more source
Neuroprotection, EarlyView.Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji +6 more
wiley +1 more source
, 2009 The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core
The frequency of yeast [PSI+] prion formation is increased during chronological ageing
Microbial Cell, 2017 Ageing involves a time-dependent decline in a variety of intracellular mechanisms and is associated with cellular senescence. This can be exacerbated by prion diseases which can occur in a sporadic manner, predominantly during the later stages of life ...
Shaun H. Speldewinde, Chris M. Grant
doaj +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)
Phytotherapy Research, EarlyView.The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo +11 more
wiley +1 more source
Editorial: The Design of Molecular Tools in Relation to Prions and Their Biosafety
Frontiers in Bioengineering and Biotechnology, 2021 Maria Lurdes Pinto +3 more
doaj +1 more source