Results 91 to 100 of about 16,731 (246)

Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease

Journal of Neuroinflammation, 2023
Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroinflammation and ...
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch   +8 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Emerging Infectious Diseases, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green   +8 more
doaj   +1 more source

Emerging and emerging common diseases in Iraq [PDF]

Iraqi Journal of Veterinary Sciences, 2009
Zoonoses are among the most common forms of disease in nature. Surveys have shown that 816 of 1,407 (58%) human pathogens, including 208 viruses and prions, 538 bacteria and worms, and 317 helminthes, were zoonotic in origin, meaning they could be ...
Dhia Muhammad Taher1 and Darem Tabbaa2
doaj   +1 more source

Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Acta Neuropathologica Communications, 2022
Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death.
Jessy A. Slota, Babu V. Sajesh, Kathy F. Frost, Sarah J. Medina, Stephanie A. Booth   +4 more
doaj   +1 more source

Prion diseases are efficiently transmitted by blood transfusion in sheep [PDF]

, 2008
The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly ...
Andréoletti, Angela Chong, Bishop, Brown, Castilla, Clarke, Fiona Houston, Goldmann, Goldmann, Goldmann, González, González, Gregori, Gregori, Hadlow, Hewitt, Hill, Hilton, Houston, Houston, Hunter, Ironside, James Foster, Jeffrey, Jeffrey, Jeffrey, Kirby, Llewelyn, Lorenzo González, Martin Jeffrey, Mead, Nora Hunter, O'Rourke, Peden, Sandra McCutcheon, Saá, Schreuder, Silvia Sisó, Sisó, Valleron, van Keulen, Wilfred Goldmann, Will, Wroe   +43 more
core   +1 more source

New Scientific and Technological Developments of Relevance to the Fifth Review Conference [PDF]

, 2001
Ye
Pearson, Graham S.
core  

Association of recurrence patterns and outcome with HR and HER2 status in patients with resected brain metastases from breast cancer

International Journal of Cancer, EarlyView.
What's New? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller, Sophie Katzendobler, Frederic Thiele, Anna Riesberg, Patrick N. Harter, Frederick Klauschen, Rachel Wuerstlein, Stephan Schoenecker, Montserrat Pazos Escudero, Robert Forbrig, Niklas Thon, Florian Ringel, Michael Weller, Emilie Le Rhun, Veit M. Stoecklein   +14 more
wiley   +1 more source

Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications

Emerging Infectious Diseases, 2015
Variant Creutzfeldt-Jakob disease (vCJD) is a rare, fatal prion disease resulting from transmission to humans of the infectious agent of bovine spongiform encephalopathy. We describe the clinical presentation of a recent case of vCJD in the United States
Atul Maheshwari, Michael Fischer, Pierluigi Gambetti, Alicia Parker, Aarthi Ram, Claudio Soto, Luis Concha-Marambio, Yvonne Cohen, Ermias D. Belay, Ryan A. Maddox, Simon Mead, Clay Goodman, Joseph S. Kass, Lawrence B. Schonberger, Haitham M. Hussein   +14 more
doaj   +1 more source

A Review on the Salt Bridge Between ASP177 and ARG163 of Wild-Type Rabbit Prion Protein

, 2015
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep and goats, cattle, deer, elks, humans and mice etc., but rabbits have a low susceptibility to be infected ...
Wang, Feng, Zhang, Jiapu
core   +2 more sources