Results 71 to 80 of about 8,300 (285)

Prions in yeast [PDF]

, 2013
The thesis describes yeast prions and their biological effects on yeast in general. It defines the basic characteristics of yeast prions, that distinguish prions from other proteins.
Bezdíčka, Martin
core  

The Utility of Prions

, 2002
Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals.
Weissman, Jonathan S., Osherovich, Lev Z.   +1 more
core   +1 more source

Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions. [PDF]

PLoS ONE, 2017
Proteins associated with neurodegenerative diseases are highly pleiomorphic and may adopt an all-α-helical fold in one environment, assemble into all-β-sheet or collapse into a coil in another, and rapidly polymerize in yet another one via divergent ...
Andrzej Stanisław Cieplak
doaj   +1 more source

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD [PDF]

, 2011
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the ...
Smith, Antony, Ian R. MacGregor, Groschup, Martin H., Hunter, N., Hunter, Nora, Prowse, C.V., Tan, B.C., Hornsey, V.S., Boon Chin Tan, Sandra McCutcheon, Jean C Manson, Antony Smith, E. Fiona Houston, Jean C. Manson, Alejo-Blanco, Richard, Manson, J.C., Tan, Boon Chin, Turner Marc, Manson, Jean C., Houston E. Fiona, Alejo Blanco, A.R., Turner, Marc, Groschup Martin H., MacGregor, Ian R., Houston, Fiona, Christopher V Prowse, Turner, M., E Fiona Houston, Alejo Blanco Anthony Richard, Groschup, M.H., Martin H Groschup, Smith Antony, de Wolf, C., Christopher V. Prowse, Hunter Nora, Prowse, Christopher V., Christopher de Wolf, Anthony Richard Alejo Blanco, MacGregor Ian R., de Wolf Christopher, Marc Turner, de Wolf, Christopher, Valerie S. Hornsey, Smith, A., Manson Jean C., Prowse Christopher V., Ian R MacGregor, Prowse, C. V., Hornsey, Valerie S., McCutcheon Sandra, MacGregor, I.R., McCutcheon, Sandra, Nora Hunter, Tan Boon Chin, Hornsey Valerie S., Martin H. Groschup, McCutcheon, S., Houston, E.F., Valerie S Hornsey   +58 more
core   +1 more source

The end of the BSE saga: do we still need surveillance for human prion diseases?

Swiss Medical Weekly, 2015
The epidemics of classical bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) related to BSE-infected food are coming to an end.
Herbert Budka, Robert G. Will
doaj   +1 more source

Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. [PDF]

PLoS ONE, 2012
Amyloid fibril formation is associated with a range of neurodegenerative diseases in humans, including Alzheimer's, Parkinson's, and prion diseases. In yeast, amyloid underlies several non-Mendelian phenotypes referred to as yeast prions.
Sam Ngo, Vicky Chiang, Elaine Ho, Linh Le, Zhefeng Guo   +4 more
doaj   +1 more source

A new method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease Resistant PrPSc

, 2010
Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrPSc, a disease-associated isoform of the host-encoded cellular ...
Gabriele Vaccari, Laura Pirisinu, Marcon Stefano, Fazzi, P., Pirisinu Laura, Michele Di Bari, Nonno Romolo, Bari, M., Di, Marcon, S., Langeveld Jan, Paola Fazzi, Cardone, F., Vaccari Gabriele, Vaccari, G., Langeveld, J.P.M., Galeno Roberta, Roberta Galeno, Pirisinu, L., Esposito Elena, Fazzi Paola, Jan Langeveld, Nonno, R., Umberto Agrimi, D'Agostino, C., Elena Esposito, Stefano Marcon, Esposito, E., Claudia D'Agostino, Agrimi Umberto, Agrimi, U., Agostino, C., D', Di Bari, M., D'Agostino Claudia, Romolo Nonno, Di Bari Michele   +34 more
core   +1 more source

Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States

Emerging Infectious Diseases
We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone.
Anatevka S. Ribeiro, Andrew B. Wolf, Ellen W. Leschek, Lawrence B. Schonberger, Joseph Y. Abrams, Ryan A. Maddox, Brian S. Appleby, Katie Glisic, Aaron Carlson, Elizabeth Matthews   +9 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source