Results 61 to 70 of about 8,300 (285)

Reflections on Cerebellar Neuropathology in Classical Scrapie

Biomolecules, 2021
In this review, the most important neuropathological changes found in the cerebella of sheep affected by classical natural scrapie are discussed. This disease is the oldest known of a group of unconventional “infections” caused by toxic prions of ...
Adolfo Toledano-Díaz, María Isabel Álvarez, Jose-Julio Rodríguez, Juan Jose Badiola, Marta Monzón, Adolfo Toledano   +5 more
doaj   +1 more source

National Variability in Prion Disease–Related Safety Policies for Neurologic Procedures

The Neurohospitalist, 2019
Prion diseases are fatal neurodegenerative disorders that can be transmitted via contact with infective tissue. Variability in hospital safety policies related to prion disease may place health-care workers at risk. We sought to assess variability of safety policies related to prion disease for neurosurgical procedures and lumbar punctures among ...
Katherine Werbaneth, Praveen Tummalapalli, Carl A. Gold   +2 more
openaire   +3 more sources

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Chronic Wasting Disease in Farmed Cervids, South Korea, 2001–2024

Emerging Infectious Diseases
Chronic wasting disease (CWD) was identified in imported elk in South Korea in 2001 and has spread among cervids nationwide. The country’s surveillance and control policy culls cervids from any CWD-positive farms, and prevalence during 2020–2024 was
Young Pyo Choi, Yu-Ran Lee, Hoo Chang Park, Yoon Hee Lee, Gordon Mitchell, In-Soon Roh, Hyun-Joo Sohn   +6 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Models for yeast prions

, 2003
The cytoplasmic heritable determinant [PSI+] of the yeast Saccharomyces cerevisiae exhibits prion-like properties. The properties of yeast prions are studied in the hope that this will enhance the understanding of mammalian prions, which cause mad-cow ...
Morgan, Byron J. T., Ruddock, Lloyd W., Ridout, Martin S.   +2 more
core   +1 more source

Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. [PDF]

, 2011
The pathogenesis of natural scrapie and other prion diseases remains unclear. Examining transcriptome variations in infected versus control animals may highlight new genes potentially involved in some of the molecular mechanisms of prion-induced ...
Bossers, A., Rosa Bolea, Hicham Filali, Varona, L., Filalil, Hicham, Harders, F., Inmaculada Martin-Burriel, Alex Bossers, Zaragoza, P., Badiola, J.J., Juan J. Badiola, Bossers, Alex, Pumarola i Batlle, Martí, Lyahyai, Jaber, Lyahyai, J., Martín Burriel, Inmaculada, Pilar Zaragoza, Juan J Badiola, Bolea, Rosa, Filali, H., Bolea, R., Acín, Cristina, Luis Varona, Frank Harders, Filali, Hicham, Pumarola, M., Harders, Frank, Zaragoza, Pilar, Badiola, Juan J, Varona, Luis, Martí Pumarola, Jaber Lyahyai, Martin-Burriel, I., Badiola, Juan José, Pumarola, Martí   +34 more
core   +1 more source

Prions and Public Health Office (PPHO) [PDF]

PPHO monitors human prion diseases in the US and coordinates programs related to these and other selected neurological diseases and illnesses of unknown causes such as Nodding syndrome and Kawasaki syndrome.

core   +2 more sources

Occurrence, Transmission, and Zoonotic Potential of Chronic Wasting Disease

Emerging Infectious Diseases, 2012
Chronic wasting disease (CWD) is a fatal, transmissible prion disease that affects captive and free-ranging deer, elk, and moose. Although the zoonotic potential of CWD is considered low, identification of multiple CWD strains and the potential for agent
Samuel E. Saunders, Shannon L. Bartelt-Hunt, Jason C. Bartz   +2 more
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source