Results 81 to 90 of about 8,300 (285)

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Emerging Infectious Diseases, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green   +8 more
doaj   +1 more source

Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease

Journal of Neuroinflammation, 2023
Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroinflammation and ...
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch   +8 more
doaj   +1 more source

Emerging and emerging common diseases in Iraq [PDF]

Iraqi Journal of Veterinary Sciences, 2009
Zoonoses are among the most common forms of disease in nature. Surveys have shown that 816 of 1,407 (58%) human pathogens, including 208 viruses and prions, 538 bacteria and worms, and 317 helminthes, were zoonotic in origin, meaning they could be ...
Dhia Muhammad Taher1 and Darem Tabbaa2
doaj   +1 more source

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]

, 2011
Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett, Daggett, Valerie, van der Kamp, Marc W, Marc W. van der Kamp   +3 more
core   +1 more source

Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States

Emerging Infectious Diseases
Using a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology.
Paulina Soto, Francisca Bravo-Risi, Rebeca Benavente, Tucker H. Stimming, Michael J. Bodenchuk, Patrick Whitley, Clint Turnage, Terry R. Spraker, Justin Greenlee, Glenn Telling, Jennifer Malmberg, Thomas Gidlewski, Tracy Nichols, Vienna R. Brown, Rodrigo Morales   +14 more
doaj   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Water and the Biology of Prions and Plaques

, 2007
This is an attempt to account for the insolubility and/or aggregation of prions and plaques in terms of a model of water consisting of an equilibrium between high density and low density microdomains.
Graham K. Steel, Phillippa M. Wiggins
core  

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG   +30 more
core   +1 more source

Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications

Emerging Infectious Diseases, 2015
Variant Creutzfeldt-Jakob disease (vCJD) is a rare, fatal prion disease resulting from transmission to humans of the infectious agent of bovine spongiform encephalopathy. We describe the clinical presentation of a recent case of vCJD in the United States
Atul Maheshwari, Michael Fischer, Pierluigi Gambetti, Alicia Parker, Aarthi Ram, Claudio Soto, Luis Concha-Marambio, Yvonne Cohen, Ermias D. Belay, Ryan A. Maddox, Simon Mead, Clay Goodman, Joseph S. Kass, Lawrence B. Schonberger, Haitham M. Hussein   +14 more
doaj   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source