Results 81 to 90 of about 16,731 (246)

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. [PDF]

PLoS ONE, 2012
Amyloid fibril formation is associated with a range of neurodegenerative diseases in humans, including Alzheimer's, Parkinson's, and prion diseases. In yeast, amyloid underlies several non-Mendelian phenotypes referred to as yeast prions.
Sam Ngo, Vicky Chiang, Elaine Ho, Linh Le, Zhefeng Guo   +4 more
doaj   +1 more source

One Health in food safety and security education: Subject matter outline for a curricular framework. [PDF]

, 2017
Educating students in the range of subjects encompassing food safety and security as approached from a One Health perspective requires consideration of a variety of different disciplines and the interrelationships among disciplines. The Western Institute
Angelos, John A, Arens, Amanda L, Cadriel, Jessica L, Johnson, Heather A, Osburn, Bennie I   +4 more
core   +3 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

The end of the BSE saga: do we still need surveillance for human prion diseases?

Swiss Medical Weekly, 2015
The epidemics of classical bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) related to BSE-infected food are coming to an end.
Herbert Budka, Robert G. Will
doaj   +1 more source

Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition

, 2012
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating ...
Chen, Jie, Thirumalai, Devarajan
core   +1 more source

Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain [PDF]

, 2010
We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates.
Menon, Kaushiki P., Salazar, Anna M., Silverman, Edward J., Zinn, Kai   +3 more
core   +2 more sources

ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

Virus Research, 2015
Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are generated by the misfolding and oligomerization of specific proteins.
Torres, Mauricio, Matamala, José Manuel, Durán Aniotz, Claudia, Cornejo, Víctor Hugo, Foley, Andrew, Hetz Flores, Claudio   +5 more
openaire   +3 more sources

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source

Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States

Emerging Infectious Diseases
We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone.
Anatevka S. Ribeiro, Andrew B. Wolf, Ellen W. Leschek, Lawrence B. Schonberger, Joseph Y. Abrams, Ryan A. Maddox, Brian S. Appleby, Katie Glisic, Aaron Carlson, Elizabeth Matthews   +9 more
doaj   +1 more source