Results 51 to 60 of about 16,731 (246)

Key points concerning amyloid infectivity and prion-like neuronal invasion

Frontiers in Molecular Neuroscience, 2016
Amyloid aggregation has been related to an increasing number of human illnesses, from Alzheimer and Parkinson’s diseases to Creutzfeldt-Jakob disease. Traditionally only prions have been considered as infectious agents with a high capacity of propagation.
Alba eEspargaró, Maria Antònia eBusquets, Joan eEstelrich, Raimon eSabate   +3 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Scrapie at Abattoir: Monitoring, Control, and Differential Diagnosis of Wasting Conditions during Meat Inspection

Animals, 2021
Wasting disease in small ruminants is frequently detected at slaughterhouses. The wasting disorder is manifested by the deterioration of the nutritional and physiological state of the animal indicated by thinness, emaciation, and cachexia.
Alexandra Esteves, Madalena Vieira-Pinto, Hélder Quintas, Leonor Orge, Adelina Gama, Anabela Alves, Fernanda Seixas, Isabel Pires, Maria de Lurdes Pinto, Ana Paula Mendonça, Carla Lima, Carla Neves Machado, João Carlos Silva, Paula Tavares, Filipe Silva, Estela Bastos, Jorge Pereira, Nuno Gonçalves-Anjo, Paulo Carvalho, Roberto Sargo, Ana Matos, Luís Figueira, Maria dos Anjos Pires   +22 more
doaj   +1 more source

Are amyloids infectious? Prions and prion-like proteins: myths and facts [PDF]

, 2018
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders affecting mammals. Albeit their low incidence in humans, prion diseases are a subject of passionate research due to their unorthodox ...
Morales Loyola, Rodrigo
core  

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). [PDF]

, 2013
Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans.
A Ertmer, A Janaszewska, A Taraboulos, AP Perez, AY Yam, B Caughey, B Caughey, B Caughey, B Klajnert, B Klajnert, B Klajnert, B Klajnert, B Klajnert, B Klajnert, DD Pless, Dietmar Appelhans, DR Borchelt, Ina Maja Vorberg, J Masel, J Solassol, James M. McCarthy, Jeremy C. Simpson, Jörg Tatzelt, K Doh-Ura, KA Nishina, KF Winklhofer, KF Winklhofer, M Fischer, M Miesbauer, Mark S. Rogers, Markus Franke, MP McKinley, N Nishida, NR Deleault, P Heegaard, PC Klohn, PJ Bosque, PMH Heegaard, R Klebe, RJ Kascsak, S Ghaemmaghami, S Gilch, S Supattapone, S Supattapone, SA Priola, SB Prusiner, SB Prusiner, Sibeal Waldron, Ulrike K. Resenberger, Y Lim   +49 more
core   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

Emerging Infectious Diseases, 2012
We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue.
Nadine Mestre-Francés, Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, Armand Perret-Liaudet, Thierry Baron, Jean-Michel Verdier   +7 more
doaj   +1 more source

Endogenous Viral Etiology of Prion Diseases [PDF]

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +1 more source