Results 131 to 140 of about 8,300 (285)

PRIONS AND PRION DISEASES

, 2004
A few typical disorders mostly manifesting by gate disturbances, muscle wasting and progressive immobility to the death, have been known in animals all around the world (sheep, goats, cats, deer’s, minks) for centuries.
Marković, Matija, Marković, Dubravko, Matija Marković, Dubravko Marković   +3 more
core  

A study of the incubation period, or age at onset, of the transmissible spongiform encephalopathies/prion diseases. [PDF]

In order to model epidemics of infectious diseases, particularly to estimate probable numbers of cases with onset at any particular time, it is necessaiy to incorporate a term for the incubation period frequency distribution. Sartwell's hypothesis states
Wooldridge, Marion Joan Anstee
core   +1 more source

Fusion protein condensate formation via coiled‐coil domains

Protein Science, Volume 35, Issue 7, July 2026.
Abstract While recent research shows that biomolecular condensates play important roles in normal cellular processes and diseases, the driving forces in condensate formation are not well understood, especially regarding the role of structured self‐associative protein domains.
Om Prakash Narayan, Lu Liu, Kyle Scheller, Carter Humphrey, Jiawei Dong, Juan Guan   +5 more
wiley   +1 more source

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Neurobiology of Disease
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is thought to occur when the cellular prion protein (PrPC) spontaneously misfolds and assembles into prion fibrils, culminating in fatal neurodegeneration.
Emma Jones, Elizabeth Hill, Jacqueline Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin Sandberg, Emmanuelle Viré, Thomas J. Cunningham, Emmanuel A. Asante, Sebastian Brandner, John Collinge, Simon Mead   +18 more
doaj   +1 more source

PolyProline Predictor: A web server for empirical sequence‐based prediction of polyproline II helices

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Polyproline II (PPII) helices are extended left‐handed secondary structures increasingly recognized for their roles in molecular recognition, signaling and within intrinsically disordered regions of proteins. Despite their functional importance, predicting regions with propensity to form PPII helices from sequence alone remains challenging due
Rubén López‐Sánchez, David Pantoja‐Uceda, Miguel Mompeán, Douglas V. Laurents   +3 more
wiley   +1 more source

Manganese Could Indirectly Promote Generation and Propagation of the Yeast Prion [URE3] and Increase Molecular Chaperones Expression in Budding Yeast

Applied Sciences
Prion diseases are caused by self-propagating and transmissible alternative conformations of certain proteins, which induce neurotoxicity and lead to transmissible spongiform encephalopathy (TSE) in mammalian.
Hui-Yong Lian, Yu-Hang Zhang, Kang-Wei Lin, Tingting Zhu   +3 more
doaj   +1 more source

A Practical Framework for GT‐Seq Panel Optimization

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Genotyping‐in‐thousands by sequencing (GT‐seq) panels are powerful tools in ecological, evolutionary and conservation genomics, yet the optimization process critical for robust and reproducible genotyping remains poorly formalized. Here, we present an iterative workflow for GT‐seq panel optimization that emphasizes systematic refinement ...
Chandika RG, Caitlin N. Ott‐Conn, Peter T. Euclide, Julie A. Blanchong, Angela Schmoldt, Randy W. DeYoung, Daniel P. Walsh, Wes A. Larson, Emily K. Latch   +8 more
wiley   +1 more source

Preface to the Special Issue “History, Biology and Pathobiology of Prions: A Field of Renewed Hopes”

Research in the field of prion diseases has not only shed light on the mechanisms underlying transmissible spongiform encephalopathies (TSEs) but has also influenced the broader understanding of protein misfolding disorders, including Alzheimer's disease
Vieira, Tuane C. R. G., Outeiro, Tiago F.   +1 more
core   +3 more sources

From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption

Agricultural Economics, Volume 57, Issue 4, July 2026.
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley   +1 more source

‘I Don't Want to Kill Any More Mice’: Taboo and Silence in PhD Education

Higher Education Quarterly, Volume 80, Issue 3, July 2026.
ABSTRACT Improving the experience and well‐being of doctoral students requires a deep and nuanced understanding of their challenges. Traditionally, researchers have used reactive methods, such as surveys and interviews, to address these issues. However, some topics may be difficult to capture through these approaches, particularly those that are ...
Saule Bekova, Ivan Smirnov
wiley   +1 more source