Results 211 to 220 of about 16,731 (246)
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Prion's Progress: Patterns and Rates of Molecular Evolution in Relation to Spongiform Disease
Journal of Molecular Evolution, 1998Modification of the cellular prion protein has been correlated with the acquisition of several neurodegenerative diseases, including kuru, scrapie, bovine spongiform encephalopathy (BSE), and Creutzfeldt-Jakob disease (CJD). Sequence conservation and amino acid identity are known to influence the efficacy of interspecific transmission.
D C, Krakauer, P M, Zanotto, M, Pagel
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Journal of Molecular Biology, 2010
The prion protein can exist both in a normal cellular isoform and in a pathogenic conformational isoform. The latter is responsible for the development of different neurodegenerative diseases, for example Creutzfeldt-Jakob disease or fatal familial insomnia.
Christian, Gerum +2 more
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The prion protein can exist both in a normal cellular isoform and in a pathogenic conformational isoform. The latter is responsible for the development of different neurodegenerative diseases, for example Creutzfeldt-Jakob disease or fatal familial insomnia.
Christian, Gerum +2 more
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The Prion Diseases: Creutzfeldt-Jakob, Gerstmann-Sträussler-Scheinker, and Related Disorders
Journal of Geriatric Psychiatry and Neurology, 1998The prion diseases are an interesting group of neurodegenerative disorders for a variety of reasons. The most obvious is their property of transmissibility, but beyond that they constitute a fascinating example of the diversity of disease expression possible from a common etiologic factor.
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British Journal of Neuroscience Nursing, 2022
Background: Most cases of dementia are due to Alzheimer's disease or vascular dementia, but attention on these disorders means that other important causes of dementia may be relatively neglected. About 10–15% of people with dementia have other diagnoses, and there are numerous causes of the less common types of dementia.
Laura Davis, Zarina Karim, Tom Dening
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Background: Most cases of dementia are due to Alzheimer's disease or vascular dementia, but attention on these disorders means that other important causes of dementia may be relatively neglected. About 10–15% of people with dementia have other diagnoses, and there are numerous causes of the less common types of dementia.
Laura Davis, Zarina Karim, Tom Dening
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Prion Protein-Related Diseases Of Man And Animals
1998Abstract Scrapie, Creutzfeldt-Jakob disease (CJD), Gerstmann- Straussler-Sheinker (GSS) syndrome and related diseases of mink (transmissible mink encephalopathy), mule deer, and elk (chronic wasting disease) are the founder members of a group of diseases called the transmissible degenerative (or spongiform) encephalopathies (TSE); the
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2000
In humans, familial forms of transmissible spongiform encephalopathies (TSE; "prion diseases") have been shown to segregate with the exchange of individual amino acids in the prion protein (PrP) sequence. We used the NMR structure of the globular domain of mouse PrP in the cellular form (PrP(C)) as a starting point for investigations by long-time ...
M, Billeter, K, Wüthrich
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In humans, familial forms of transmissible spongiform encephalopathies (TSE; "prion diseases") have been shown to segregate with the exchange of individual amino acids in the prion protein (PrP) sequence. We used the NMR structure of the globular domain of mouse PrP in the cellular form (PrP(C)) as a starting point for investigations by long-time ...
M, Billeter, K, Wüthrich
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Journal of the American Dietetic Association, 2011
The transmission of bovine spongiform encephalopathy (BSE) to human beings and the spread of chronic wasting disease (CWD) among cervids have prompted concerns about zoonotic transmission of prion diseases. Travel to the United Kingdom and other European countries, hunting for deer or elk, and venison consumption could result in the exposure of US ...
Joseph Y, Abrams +4 more
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The transmission of bovine spongiform encephalopathy (BSE) to human beings and the spread of chronic wasting disease (CWD) among cervids have prompted concerns about zoonotic transmission of prion diseases. Travel to the United Kingdom and other European countries, hunting for deer or elk, and venison consumption could result in the exposure of US ...
Joseph Y, Abrams +4 more
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Mini-Reviews in Medicinal Chemistry, 2008
Nucleic acids catalyse the conversion of alpha-helical prion protein to the beta-structured protein oligomers and amyloids structurally similar to the infectious isoform of protein. Simultaneously, the prion protein, similar to gene regulating proteins, bends, unwinds and condenses nucleic acid.
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Nucleic acids catalyse the conversion of alpha-helical prion protein to the beta-structured protein oligomers and amyloids structurally similar to the infectious isoform of protein. Simultaneously, the prion protein, similar to gene regulating proteins, bends, unwinds and condenses nucleic acid.
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Biochemical and Biophysical Research Communications, 2006
Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer's disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer's peptide Abeta1-28 and the segment of the prion protein Prp185-208.
Barbara, Klajnert +3 more
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Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer's disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer's peptide Abeta1-28 and the segment of the prion protein Prp185-208.
Barbara, Klajnert +3 more
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1994
"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen,temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundanoluşan küçük, proteinden zengin, infeksiyöz partiküller" olaraktanımlanabilirler (42).Genetik bilginin nükleik asitlerden proteinlere dönüşümü , molekülerbiyolojinin temel doktrini olarak ...
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"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen,temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundanoluşan küçük, proteinden zengin, infeksiyöz partiküller" olaraktanımlanabilirler (42).Genetik bilginin nükleik asitlerden proteinlere dönüşümü , molekülerbiyolojinin temel doktrini olarak ...
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