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Evolution of the PRNT: Merging tradition and innovation to set the gold standard in the era of automation [PDF]

Human Vaccines and Immunotherapeutics
The plaque reduction neutralization test (PRNT) is the gold standard for quantifying neutralizing antibodies owing to its high sensitivity and specificity.
Azevedo As, Sheila Maria Barbosa de Lima, Denani C B   +2 more
exaly   +4 more sources

Pseudovirus-Based Neutralization Assays as Customizable and Scalable Tools for Serological Surveillance and Immune Profiling [PDF]

Pathogens
Neutralizing antibodies (nAbs) are key indicators of protection against SARS-CoV-2, and their measurement remains essential for monitoring vaccine responses and population immunity.
Caio Bidueira Denani, Bruno Pimenta Setatino, Denise Pereira, Ingrid Siciliano Horbach, Adriana Souza Azevedo, Gabriela Coutinho, Clara Lucy Ferroco, Janaína Xavier, Robson Leite, Ewerton Santos, Maria de Lourdes Maia, Waleska Dias Schwarcz, Ivanildo Pedro Sousa   +12 more
doaj   +2 more sources

Plaque Reduction Neutralization Test (PRNT) Accuracy in Evaluating Humoral Immune Response to SARS-CoV-2

Diseases (Basel, Switzerland)
Massive vaccination positively impacted the SARS-CoV-2 pandemic, being a strategy to increase the titers of neutralizing antibodies (NAbs) in the population.
Azevedo As, Sheila Maria Barbosa de Lima, Tamiris Azamor   +2 more
exaly   +3 more sources

Value of anatomical partitioning of the retroperitoneal space in determining the origin of neurogenic tumors [PDF]

BMC Cancer
Background To analyze the anatomical partitioning of the retroperitoneal space and determine the distribution patterns of primary retroperitoneal neurogenic tumors (PRNTs).
Yuwei Li, Haowen Zhao, Jingjing Chen, Huacheng Chen, Guangmao Ni, Yanming Ge, Chunjing Liang, Peng Dong   +7 more
doaj   +2 more sources

Is prnt a Pseudogene? Identification of Ram Prt in Testis and Ejaculated Spermatozoa

PLoS ONE, 2012
A hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (PrP(C)), expressed by the prion gene (prnp), into an abnormally folded isoform (PrP(Sc)) with amyloid-like features that causes ...
João Gonçalves, Jorge Pimenta, Ana Domingos   +2 more
exaly   +3 more sources

Comparison of measles plaque reduction neutralization test (PRNT) and measles virus-specific IgG ELISA for assessment of immunogenicity of measles-mumps-rubella vaccination at 5–7 months of age and maternal measles antibodies

Vaccine: X
Background: Assessing the risk of measles outbreaks and identifying the susceptible parts of the population is essential to timely intervention. Infants between 6–12 months are increasingly susceptible to measles but evaluating the performance of high ...
, Dörthe Maria Vittrup, Jannet Svensson   +2 more
exaly   +3 more sources

An exploratory study to assess the influence of schistosomiasis on the occurrence of dengue virus in Madagascar [PDF]

Infectious Diseases of Poverty
Background Dengue virus (DENV) is the most prevalent mosquito-borne virus worldwide, with approximately half of the world’s population at risk of infection.
Jana Christina Hey, Tahinamandranto Rasamoelina, Anjarasoa Ravo Razafindrakoto, Nantenaina Matthieu Razafindralava, Zaraniaina Tahiry Rasolojaona, Stephanie Leyk, Sreejith Rajasekharan, Lucas Wilken, Tiana Randrianarisoa, Tojo Rémi Rafaralahivoavy, Jacques Hainasoa, Raphael Rakotozandrindrainy, Njary Randriamampionona, Norbert Georg Schwarz, Anna Jaeger, Aaron Remkes, Jean-Marc Kutz, Pia Rausche, Irina Kislaya, Valentina Marchese, Christa Ehmen, Christina Deschermeier, Jürgen May, Lidia Bosurgi, Rivo Andry Rakotoarivelo, Pietro Scaturro, Daniela Fusco   +26 more
doaj   +2 more sources

Chimeric Vesicular Stomatitis Virus Bearing Western Equine Encephalitis Virus Envelope Proteins E2-E1 Is a Suitable Surrogate for Western Equine Encephalitis Virus in a Plaque Reduction Neutralization Test [PDF]

Viruses
In December 2023, infections of western equine encephalitis virus (WEEV) within Argentina were reported to the World Health Organization (WHO). By April 2024, more than 250 human infections, 12 of which were fatal, and 2500 equine infections were ...
Kerri L. Miazgowicz, Bailey E. Maloney, Melinda A. Brindley, Mattie Cassaday, Raegan J. Petch, Paul Bates, Aaron C. Brault, Amanda E. Calvert   +7 more
doaj   +2 more sources

A Single-Round Infection Fluorescent SARS-CoV-2 Neutralization Test for COVID-19 Serological Testing at a Biosafety Level-2 Laboratory

Viruses, 2022
A robust serological test to measure neutralizing antibodies against SARS-CoV-2 in biosafety level-2 (BSL-2) laboratories is useful for monitoring antibody response after vaccination or natural infection.
Jing Zou, Hongjie Xia, Pei-Yong Shi, Xuping Xie, Ping Ren   +4 more
doaj   +1 more source

Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

Frontiers in Cellular and Infection Microbiology, 2022
For the clinical application of semi-quantitative anti-SARS-CoV-2 antibody tests, the analytical performance and titer correlation of the plaque reduction neutralization test (PRNT) need to be investigated.
Beomki Lee, Jae-Hoon Ko, Jiho Park, Hee-Won Moon, Jin Yang Baek, Sunhee Jung, Hee-Young Lim, Kyung-Chang Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Hee Jae Huh, Chi Ryang Chung, Yae-Jean Kim, Eun-Jeong Joo, Eun-Suk Kang, Kyong Ran Peck   +17 more
doaj   +1 more source