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Evolution of the PRNT: Merging tradition and innovation to set the gold standard in the era of automation [PDF]
Human Vaccines and ImmunotherapeuticsThe plaque reduction neutralization test (PRNT) is the gold standard for quantifying neutralizing antibodies owing to its high sensitivity and specificity.
Adriana Souza Azevedo +2 more
exaly +4 more sources
A multiplex serological assay for quantification of arbovirus antibody kinetics and neutralizing antibodies. [PDF]
PLoS Neglected Tropical DiseasesArboviruses such as dengue virus (DENV) and chikungunya virus (CHIKV) pose major global health threats. To support serological surveillance and study cross-reactivity, an in-house multiplex bead-based immunoassay was developed to measure IgG responses ...
Laura Garcia +23 more
doaj +2 more sources
Diseases (Basel, Switzerland)Massive vaccination positively impacted the SARS-CoV-2 pandemic, being a strategy to increase the titers of neutralizing antibodies (NAbs) in the population.
Adriana Souza Azevedo +2 more
exaly +3 more sources
Is prnt a Pseudogene? Identification of Ram Prt in Testis and Ejaculated Spermatozoa
PLoS ONE, 2012 A hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (PrP(C)), expressed by the prion gene (prnp), into an abnormally folded isoform (PrP(Sc)) with amyloid-like features that causes ...
Joao Goncalves +2 more
exaly +3 more sources
Vaccine: XBackground: Assessing the risk of measles outbreaks and identifying the susceptible parts of the population is essential to timely intervention. Infants between 6–12 months are increasingly susceptible to measles but evaluating the performance of high ...
Jesper Kiehn Sørensen, Jannet Svensson
exaly +3 more sources
Pseudovirus-Based Neutralization Assays as Customizable and Scalable Tools for Serological Surveillance and Immune Profiling [PDF]
PathogensNeutralizing antibodies (nAbs) are key indicators of protection against SARS-CoV-2, and their measurement remains essential for monitoring vaccine responses and population immunity.
Caio Bidueira Denani +12 more
doaj +2 more sources
An exploratory study to assess the influence of schistosomiasis on the occurrence of dengue virus in Madagascar [PDF]
Infectious Diseases of PovertyBackground Dengue virus (DENV) is the most prevalent mosquito-borne virus worldwide, with approximately half of the world’s population at risk of infection.
Jana Christina Hey +26 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 For the clinical application of semi-quantitative anti-SARS-CoV-2 antibody tests, the analytical performance and titer correlation of the plaque reduction neutralization test (PRNT) need to be investigated.
Beomki Lee +17 more
doaj +1 more source
Viruses, 2022 A robust serological test to measure neutralizing antibodies against SARS-CoV-2 in biosafety level-2 (BSL-2) laboratories is useful for monitoring antibody response after vaccination or natural infection.
Jing Zou +4 more
doaj +1 more source
Scientific Reports, 2021 The present study aimed to investigate whether the serum biomarkers of immune response orchestrate the seroconversion status in patients with autoimmune diseases (AID) upon planned primary 17DD-YF vaccination.
Ismael Artur da Costa-Rocha +28 more
doaj +1 more source