Journal of Research in Medical Sciences, 2011 Background: The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor. It is predominantly expressed in adipose tissue and as a receptor for thiazolidinediones, it has drawn attentions towards itself as a key molecule to ...
Fatemeh Namvaran +2 more
doaj +3 more sources
PPAR𝛾2Pro12Ala Polymorphism and Human Health [PDF]
PPAR Research, 2009 The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR𝛾) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity.
Weimin He
doaj +2 more sources
Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management. [PDF]
Endocrinol Diabetes MetabGenetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Ngcobo NN, Sibiya NH.
europepmc +2 more sources
Investigation of the association of Pro12Ala polymorphism in the PPARG gene with the occurence of obesity and metabolic syndrome in postmenopausal women [PDF]
Medicinski PodmladakIntroduction: During menopause, the prevalence of metabolic disorders in women increases significantly. Postmenopausal women have increased waist circumference, high blood pressure, hypertriglyceridemia, hyperglycemia and low HDL cholesterol, which leads
Pucar Aleksandra +3 more
doaj +2 more sources
Association of PPARγ2 Pro12Ala polymorphism with gestational diabetes mellitus risk: A systematic review and meta-analysis [PDF]
Biomolecules & BiomedicineGestational diabetes mellitus (GDM) is a prevalent pregnancy complication that poses significant risks to both mothers and their offspring, with genetic susceptibility believed to play a role in its pathogenesis.
Yuanting Xu +4 more
doaj +2 more sources
Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2? [PDF]
PPAR Research, 2013 Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders.
A. C. Pereira +3 more
doaj +2 more sources
Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy
Клиническая и экспериментальная тиреоидология, 2013 AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals.
D M Serkin +5 more
doaj +3 more sources
PPARgamma Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes. [PDF]
BMC Med Genet, 2009 Background: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays a key role in the regulation of the energy balance, adipocyte differentiation ...
Vogel U +9 more
europepmc +7 more sources
The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population [PDF]
PPAR Research, 2014 Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis.
Guoda Ma +13 more
doaj +2 more sources
PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome [PDF]
Cardiovascular Diabetology, 2011 Background Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and Angiotensin Converting Enzyme (ACE)
Passaro Angela +8 more
doaj +2 more sources