Results 21 to 30 of about 3,465 (237)

Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover. [PDF]

Adipocyte, 2018
Kamble PG, Pereira MJ, Gustafsson S, Lundkvist P, Castillejo-López C, Fall T, Ingelsson E, Eriksson JW.   +7 more
europepmc   +3 more sources

Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status. [PDF]

PLoS ONE, 2013
BackgroundThe 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes.
Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Pawel Cieszczyk, Aleksandra Zarebska, Stanislaw Sawczyn   +4 more
doaj   +2 more sources

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Nature Genetics, 2000
Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in multiple samples and with comprehensive controls. We evaluated 16 published genetic associations to type 2 diabetes and related sub-phenotypes using a family-based design to ...
Altshuler, D, Hirschhorn, J, Klannemark, M, Lindgren, C, Vohl, M, Nemesh, J, Lane, C, Schaffner, S, Bolk, S, Brewer, C, Tuomi, T, Gaudet, D, Hudson, T, Daly, M, Groop, L, Lander, E   +15 more
openaire   +4 more sources

Association of PPARG Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome. [PDF]

Biomed Rep, 2014
Baldani DP, Skrgatic L, Cerne JZ, Ferk P, Simunic V, Gersak K.   +5 more
europepmc   +3 more sources

The impact of PPARγ and ApoE gene polymorphisms on susceptibility to diabetic kidney disease in type 2 diabetes mellitus: a meta-analysis [PDF]

BMC Nephrology
Background Globally, diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease, imposing substantial social and economic costs.
Binura Taurbekova, Kymbat Mukhtarova, Zhandos Salpynov, Kuralay Atageldiyeva, Antonio Sarria-Santamera   +4 more
doaj   +2 more sources

Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor, has been implicated playing a role in the development of inflammatory bowel disease (IBD).
Zhi-Feng Zhang, Ning Yang, Gang Zhao, Lei Zhu, Li-Xia Wang   +4 more
doaj   +2 more sources

The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) is associated with increased risk of coronary artery disease: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND: Contradictory results have been reported regarding the association between Pro12Ala polymorphism of PPARγ2 and coronary artery disease (CAD). We sought to estimate the inconsistent results by performing a comprehensive meta-analysis. METHODS:
Zhijun Wu, Yuqing Lou, Wei Jin, Yan Liu, Lin Lu, Guoping Lu   +5 more
doaj   +2 more sources

Association Between Pro12Ala Polymorphism of Peroxisome ProliferatorActivated Receptor Gamma (PPARγ) and Components of Metabolic Syndrome

Endocrinology Research and Practice, 2010
Objective: Metabolic syndrome is a highly prevalent complex disorder characterized by abdominal obesity, insulin resistance, dyslipidemia and hypertension. It occurs as a result of the interaction between genetic susceptibility and environmental factors,
Tomris Erbaş
doaj   +3 more sources

Evaluation of single nucleotide polymorphisms of Pro12Ala in peroxisome proliferator-activated receptor-γ and Gly308Ala in tumor necrosis factor-α genes in obese Asian Indians: a population-based study

Diabetes, Metabolic Syndrome and Obesity, 2010
Namita Bhagat1,2, Mukta Agrawal1, Kalpana Luthra3, Naval K Vikram4, Anoop Misra4, Rajeev Gupta21Department of Home Science, University of Rajasthan, Jaipur, Rajasthan, India; 2Department of Medicine, Fortis Escorts Hospital, Jaipur, Rajasthan, India ...
Namita Bhagat, Mukta Agrawal, Kalpana Luthra, et al   +3 more
doaj   +3 more sources

The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated to obesity and type 2 diabetes mellitus in a Cameroonian population. [PDF]

BMC Obes, 2016
Mato EPM, Pokam-Fosso PE, Atogho-Tiedeu B, Noubiap JJN, Evehe MS, Djokam-Dadjeu R, Donfack OS, Ngwa EN, Guewo-Fokeng M, Mbacham WF, Sobngwi E, Mbanya JC.   +11 more
europepmc   +2 more sources