Results 41 to 50 of about 3,465 (237)

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth [PDF]

Diabetes, 2007
The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator–activated receptor γ (PPARG) gene could play a role in ...
Meirhaeghe, A, Boreham, CAG, Murray, LJ, Richard, F, Davey Smith, G, Young, IS, Amouyel, P   +6 more
openaire   +4 more sources

Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus-A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Pro12Ala polymorphism is a missense mutation at codon 12 in peroxisome proliferator-activated receptor γ gene (PPARG). This polymorphism is known to be associated with increased insulin sensitivity. Pioglitazone, a thiazolidinedione, is
S. Shanmuga Priya, Ramalingam Sankaran, Sudha Ramalingam, Thiagarajan Sairam, LS Somasundaram   +4 more
doaj   +1 more source

Targeting the EZH2‐PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer

PPAR Research, Volume 2021, Issue 1, 2021., 2021
Enhancer of zeste homolog 2 (EZH2) is abnormally highly expressed in pancreatic cancer (PC). However, it is not ideal to treat PC by inhibiting EZH2. This study reported that the combined use of pan‐peroxisome proliferator‐activated receptor (PPAR) agonist could significantly improve the anti‐PC effect of EZH2 inhibitor.
Jilong Hu, Zhinan Zheng, Jia Lei, Yuxin Cao, Qiyun Li, Zhi Zheng, Chuanjun Chen, Stéphane Mandard   +7 more
wiley   +1 more source

Pathophysiologic Mechanisms of Insulin Secretion and Signaling‐Related Genes in Etiology of Polycystic Ovary Syndrome

Genetics Research , Volume 2021, Issue 1, 2021., 2021
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women. PCOS is characterized by anovulation, hyperandrogenism, polycystic ovaries, insulin resistance, and obesity. Despite the finding that the genetic origin of PCOS is well demonstrated in previous twin and familial clustering studies, genes and factors that can exactly explain the PCOS ...
Zahra Shaaban, Arezoo Khoradmehr, Amir Amiri-Yekta, Fariborz Nowzari, Mohammad Reza Jafarzadeh Shirazi, Amin Tamadon, Hafiz Ishfaq Ahmad   +6 more
wiley   +1 more source

PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese

PPAR Research, Volume 2021, Issue 1, 2021., 2021
The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator‐activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program.
Glêbia A. Cardoso, Mateus D. Ribeiro, Bruno R. V. Sousa, Yohanna de Oliveira, Klécia F. Sena, Joane R. E. Batista, Antônio E. M. Almeida, João M. Filho, Raquel S. B. Silva, Darlene C. Persuhn, Alexandre S. Silva, Pascal Froment   +11 more
wiley   +1 more source

Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and non-alcoholic fatty liver disease [PDF]

Archives of Biological Sciences, 2013
The aim of this study was to analyze the relationship between Pro12Ala substitution in the peroxisome proliferator-activated receptor gamma (PPARy) gene and non-alcoholic fatty liver disease (NAFLD).
Chen Shao-Hua, Ying Lixiong, Wu Chenjiao, Wang Qunyan, Li You-Ming   +4 more
doaj   +1 more source

Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus

Journal of Genetic Engineering and Biotechnology, 2017
Objective: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene is one of the possible genes linking diabetes mellitus (DM) with coronary artery disease (CAD).
Nehal Salah Hasan, Solaf Ahmed Kamel, Mona Hamed, Eman Awadallah, Amany Hosny Abdel Rahman, Nevine Ibrahim Musa, Ghada Hussein Sayed Hussein   +6 more
doaj   +1 more source

The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome. [PDF]

Int J Clin Exp Pathol, 2013
Yang J, Gong H, Liu W, Tao T.
europepmc   +2 more sources

CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARγ gene [PDF]

Journal of Physiology and Biochemistry, 2002
Obesity in humans results from combined effects of genes, environment and lifestyles. A case-control study (obese vs. lean controls) was conducted to assess the possible association between obesity risk and the Pro12Ala polymorphism of the PPARg gene depending on the dietary intake.The study population comprised 313 Spanish subjects (66 men), which ...
Martinez, J.A. (José Alfredo), Martinez-Gonzalez, M.A. (Miguel Ángel), Forga, L. (Luis), Marti-del-Moral, A. (Amelia), Corbalan, M. (M.S.)   +4 more
openaire   +3 more sources

The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]

, 2016
The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica, Bacci, Simonetta, Cignarelli, Mauro, Copetti, Massimiliano, De Cosmo, Salvatore, Fontana, Andrea, Lamacchia, Olga, Marucci, Antonella, Mercuri, Luana, Pacilli, Antonio, Palena, Antonio, Prudente, Sabrina, Trischitta, Vincenzo, Viti, Raffaella   +13 more
core   +1 more source