Results 61 to 70 of about 3,465 (237)

Genome-wide scanning versus candidate gene approach in the genetic architecture of common diseases. [PDF]

, 2007
In the Nature 7 June issue, researchers from the Welcome Trust Case Control Consortium (WTCCC) reported the findings of a large genome-wide association (GWA) study of 14,000 cases of common diseases and 3000 controls studies revealing the role of several
Carlos J. Pirola, Silvia Sookoian
core   +2 more sources

Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ [PDF]

, 2014
AIM: The aim of the study was to estimate the influence of interactions between peroxisome proliferator-activated receptor γ (PPARγ) and target genes lipoprotein lipase (LPL), interleukin 6 (IL6), angiotensin converting enzyme (ACE), and angiotensin ...
Božina, Tamara, Jelaković, Bojan, Lovrić, Jasna, Reiner, Željko, Sertić, Jadranka, Šimić, Iveta   +5 more
core   +1 more source

Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study

Journal of Sleep Research, Volume 29, Issue 4, August 2020., 2020
Abstract Obstructive sleep apnea is associated with an increased risk of hypertension, diabetes and dyslipidaemia. Both obstructive sleep apnea and its comorbidities are at least partly heritable, suggesting a common genetic background. Our aim was to analyse the heritability of the relationship between obstructive sleep apnea and its comorbidities ...
Martina Meszaros, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Daniel Tamas Kovacs, Bianka Forgo, Jooyeon Lee, Joohon Sung, Jørgen Vestbo, Veronika Müller, Laszlo Kunos, Andras Bikov   +10 more
wiley   +1 more source

Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa [PDF]

, 2014
Please cite as follows: Vergotine, Z. et al. 2014. Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from ...
Andre P Kengne, Rajiv T Erasmus, Tandi E Matsha, Yandiswa Y Yako, Zelda Vergotine   +4 more
core   +3 more sources

Association of Peroxisome Proliferator‐Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers

PPAR Research, Volume 2020, Issue 1, 2020., 2020
Diabetic retinopathy (DR) is a condition that develops after long‐lasting and poorly handled diabetes and is presently the main reason for blindness among elderly and youth. Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors that are involved in carbohydrate and fatty‐acid metabolism and have also been associated with DR.
Špela Tajnšek, Danijel Petrovič, Mojca Globočnik Petrovič, Tanja Kunej, John P. Vanden Heuvel   +4 more
wiley   +1 more source

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. [PDF]

, 2012
Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction ...
Galbete, C. (Cecilia), Guillen-Grima, F. (Francisco), Marti, A. (Amelia), Martinez, J.A. (José Alfredo), Martinez-Gonzalez, M.A. (Miguel Ángel), Toledo, J. (Jon)   +5 more
core   +1 more source

Qatari Genotype May Contribute to Complications in Type 2 Diabetes

Journal of Diabetes Research, Volume 2020, Issue 1, 2020., 2020
Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory.
Youssra Dakroury, Stephen L. Atkin, Soha R. Dargham, Amal Robay, Juan Rodriguez-Flores, Ronald G. Crystal, Alexandra E. Butler, Eusebio Chiefari   +7 more
wiley   +1 more source

Associations between PPARG polymorphisms and the risk of essential hypertension. [PDF]

PLoS ONE, 2017
BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH). It has been suggested that polymorphisms of PPARG are associated with the risk of EH. However,
Gaojun Cai, Xinyong Zhang, Weijin Weng, Ganwei Shi, Sheliang Xue, Bifeng Zhang   +5 more
doaj   +1 more source

UEG Week 2023 Moderated Posters

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

The C1431T polymorphism of peroxisome proliferator activated receptor γ (PPARγ) is associated with low risk of diabetes in a Pakistani cohort [PDF]

, 2016
BACKGROUND: Diabetes is a socioeconomic burden in Pakistan. International diabetes federation reported 6.9 million cases of diabetes and 87,548 deaths due to diabetes in Pakistan in 2014.
Huma Butt, null Shabana, Shahida Hasnain
core   +1 more source