FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Tunnel enabled programmable switches obfuscate network topology to defend against link flooding reconnaissance in software defined networking. [PDF]
Sci RepLi X, Lee J, Son J, Lee Y.
europepmc +1 more source
A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases
, 2005 Muh‐Ching Yee +4 more
openalex +1 more source
Vertical Transmission of Listeria monocytogenes: Probing the Balance between Protection from Pathogens and Fetal Tolerance [PDF]
, 2018 Nicole Lamond, Nancy E. Freitag
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FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Prompt gamma imaging vs. range probing: Experimental comparison of two range verification approaches for proton therapy. [PDF]
Med PhysBertschi S +9 more
europepmc +1 more source
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
, 2007 Sam Hay +2 more
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FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
Retrospective Evaluation of Peri-Implant Maintenance in Patients With Implant-Supported Fixed Prostheses. [PDF]
Int J DentMaghsoudi P +3 more
europepmc +1 more source
Probing disrupted neurodevelopment in autism using human stem cell‐derived neurons and organoids: An outlook into future diagnostics and drug development [PDF]
, 2019 Guang Yang, Aleksandr Shcheglovitov
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