Results 41 to 50 of about 130,011 (340)

Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation

Biomedicines, 2023
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement [PDF]

, 2018
Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the ...
Chen, Yi-Chieh, Ferreira, Carla Sofia, Lue, Leo, Sefcik, Jan, Thennadil, Suresh, Tiernan-Vandermotten, Sarra   +5 more
core  

Cross-Bridge Kelvin resistor structures for reliable measurement of low contact resistances and contact interface characterization [PDF]

, 2009
The parasitic factors that strongly influence the measurement accuracy of Cross-Bridge Kelvin Resistor (CBKR) structures for low specific contact resistances (rhoc) have been extensively discussed during last few decades and the minimum of the rhoc value,
Klootwijk, J.H., Kovalgin, A.Y., Stavitski, N., Wolters, R.A.M., Zeijl, H.W. van   +4 more
core   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cylindrical IR-ATR Sensors for Process Analytics

Sensors, 2020
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitive ...
Armin Lambrecht, Carsten Bolwien, Jochen Erb, Hendrik Fuhr, Gerd Sulz   +4 more
doaj   +1 more source

Identifying pharmaceutical manufacturing equipment's surface roughness and mitigating robustness concerns when using specular reflectance Fourier-transform infrared (FTIR) spectroscopy for rapid cleaning verification

Talanta Open, 2022
Preventing cross-contamination during manufacturing is a regulatory requirement in the pharmaceutical manufacturing industry. One element of measures to prevent cross-contamination is the validation of cleaning processes for manufacturing equipment by ...
Apu Sarwar, Conor McSweeney, Joep Timmermans, Eric Moore   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Current Industry Perspective on Process Analytical Technique Tools and their Recent Development in Pharmaceutical Oral Solid Dosage Formulations

Journal of Pharmacy
Current review offers extensive understanding and implementation of process analytical technology (PAT) tools in manufacturing of pharmaceutical oral solid dosage (OSD) forms to streamline product’s time to reach to market and increase profitability ...
Chinna Reddy Palem, Vamshi Krishna Lekkala   +1 more
doaj   +1 more source

Study on the Growth and Regulation of Large-Particle Sr(OH)₂·8H₂O Crystals with Process Analytical Technology

Crystals, 2023
Sr(OH)2 is an indispensable strontium compound extensively harnessed in sugar refining, strontium lubricating wax formulation, and polymer plastic stabilization. Sr(OH)2·8H2O is the prevalent hydrate form of Sr(OH)2.
Binbin Shi, Yongjuan Zhang, Shudong Liang, Yanan Wang, Yan Jing, Xingwu Zou, Xuezhong Wang   +6 more
doaj   +1 more source