Results 51 to 60 of about 130,011 (340)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The application of NIR spectroscopy with chemometric analysis for monitoring the powder blending process [PDF]
Journal of the Serbian Chemical Society, 2014 This paper reports the use of Near Infrared (NIR) spectroscopy as a Process Analytical Technology (PAT) tool for monitoring the metformin hydrochloride and polyvinilpyrolidone (PVP) mixing process, which is the first stage in the tablet ...
Marić Ljiljana B. +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The application of mathematical and statistical methods in industry
Revista Técnica de la Facultad de Ingeniería, 2012 Chemometrics has been defined as “The discipline that uses mathematical and statistical methods for selection or design of optimal experimental conditions, and to provide relevant information from chemical data”.
Carlos Alciaturi +3 more
doaj
Process analytical technology (PAT) in continuous bioprocessing [PDF]
, 2017 In recent years biotech companies have been emphasizing on the implementation and utilization of process analytical technology (PAT) in continuous bioprocessing.
Botonjic-Sehic, Edita
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing
Scientific Reports, 2022 In the development of end-to-end large-scale live virus vaccine (LVV) manufacturing, process analytical technology (PAT) tools enable timely monitoring of critical process parameters (CPP) and significantly guide process development and characterization.
Sijia Yi +11 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Journal of Traditional Chinese Medical Sciences, 2018 Objective: A novel processing analytical framework of Chinese Material Medica (CMM) includes breeding process analysis, planting process analysis, producing process analysis and manufacture process analysis.
Jiangbo Hao +4 more
doaj +1 more source
Polydisperse Adsorption: Pattern Formation Kinetics, Fractal Properties, and Transition to Order
, 1998 We investigate the process of random sequential adsorption of polydisperse particles whose size distribution exhibits a power-law dependence in the small size limit, $P(R)\sim R^{\alpha-1}$.
A. Yokoyama +27 more
core +1 more source