Results 101 to 110 of about 138,359 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Ultra-Processed Foods [PDF]

Foods that are highly processed (ultra-processed foods - UPFs) are increasingly popular among consumers for reasons of affordability and convenience, yet research indicates that that they are detrimental to health and environmental sustainability ...
Caraher, Martin, Furey, Sinéad
core   +2 more sources

Associations between degree of food processing and all-cause and cause-specific mortality: a multicentre prospective cohort analysis in 9 European countriesResearch in context

The Lancet Regional Health. Europe
Summary: Background: Ultra-processed food (UPF) consumption has been linked with higher risk of mortality. This multi-centre study investigated associations between food intake by degree of processing, using the Nova classification, and all-cause and ...
Esther M. González-Gil, Michèle Matta, Fernanda Morales Berstein, Manon Cairat, Geneviève Nicolas, Jessica Blanco, Nathalie Kliemann, Renata Bertazzi Levy, Fernanda Rauber, Inarie Jacobs, Aline Al Nahas, Emine Koc Cakmak, Eszter P. Vamos, Kiara Chang, Sahar G. Yammine, Christopher Millett, Mathilde Touvier, Maria Gabriela Matias Pinho, Konstantinos K. Tsilidis, Alicia K. Heath, Christina M. Lill, Valeria Pala, Conchi Moreno-Iribas, Maria Santucci De Magistris, Christina C. Dahm, Niels Bock, Anja Olsen, Anne Tjønneland, Yvonne T. van der Schouw, Pilar Amiano, Franziska Jannasch, Matthias B. Schulze, Francesca Romana Mancini, Chloé Marques, Claire Cadeau, Catalina Bonet, Daniel Redondo-Sánchez, Kristin Benjaminsen Borch, Magritt Brustad, Guri Skeie, Jesús Humberto-Gómez, Alessandra Macciotta, Pietro Ferrari, Laure Dossus, Marc J. Gunter, Inge Huybrechts   +45 more
doaj   +1 more source

Ultra - processed foods and their impact on health [PDF]

, 2020
This bachelor thesis deals with ultra-processed foods and their impact on health. The thesis is divided into two parts. In the first theoretical, there is summarized information about ultra- processed foods, health risk ingedients and food processing. It
Hromířová, Eliška
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genetically modified foods, trade, and developing countries [PDF]

This paper analyzes price, production and trade consequences of changing consumer preferences regarding the use of genetically modified organisms (GMOs) in food production.
Robinson, Sherman, Nielsen, Chantal Pohl, Thierfelder, Karen   +2 more
core  

Why are Foods Processed?

, 2020
Foods are processed in order to extend shelf life, enhance flavor, increase safety, and improve nutrient ...
Boyer, Renee R., Arnold, Nicole, Yang, Lily   +2 more
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Avoid ultra-processed foods, not food processing: Why processed foods matter for nutrition security, economic growth, gender equality, and sustainability agendas in Africa

World Nutrition
With rising levels of obesity and associated non-communicable diseases in Africa, there is an increasing concern with regards to ultra-processed foods.
Hannah Ameye, Katrin Glatzel
doaj   +1 more source