Results 161 to 170 of about 1,962,028 (312)
, 2017 Given the variety of crop growth models and their relative strengths and weaknesses, ensembles of crop models are being progressively developed for yield/production forecasting purposes, quantification of the impact on yield of changes due to climate or ...
McRae, David +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Estimating Variable Returns to Scale Production Frontiers with Alternative Stochastic Assumptions [PDF]
A stochastic production frontier model is formulated within the generalized production function framework popularized by Zellner and Revankar (1969) and Zellner and Ryu (1998).
Christopher J. O’Donnell +1 more
core
Determining Optimal Levels of Nitrogen Fertilizer Using Random Parameter Models
The parameters of yield response functions can vary by year. Past studies usually assume yield functions are nstochastic ‘‘limited’’ stochastic. In this study, we estimate rye– ryegrass yield functions in which all parameters are random.
Biermacher, Jon T. +5 more
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Business and IT alignment in context
, 2013 Already for more than two decades, the necessity and desirability of aligning business needs and information technology (IT) capabilities is considered to be one of the key issues in IT management.
Silvius, A.J.G. +2 more
core
Production of shellfish production models
, 1985 The first definition we could give to model is quite general : a model is any representation of the real world or what it is supposed to be at a given moment ; it clearly depends on the knowledge about reality or part of it ; as an abstraction it is necessary based on concepts and assumptions.
openaire +1 more source