Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Technical Change as Exogenous or Endogenous Factor in the Production Function Models. Empirical Evidence from Romania [PDF]
As technical change is nowadays largely accepted to be an engine of economic growth, researchers have tried to include it explicitly in the economic growth models, either as an exogenous or endogenous factor of influence.
Zaman, Gheorghe, Goschin, Zizi
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Editorial: Models and Theories of Speech Production
Frontiers in Psychology, 2020 Adamantios Gafos, Pascal van Lieshout
doaj +1 more source
Forecasting egg production in free-range laying hens using multi-farm data. [PDF]
Poult SciAdejola YA +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Nonlinear regression modeling of ruminal fermentation dynamics in buffered diets using in vitro gas production. [PDF]
PLoS OneAsadollahi Seyedabadi Z +3 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Characterization of production in different branches of production in different branches spanish industrial activity, by means of time series analysis. [PDF]
This work presents a quantitative study of the evolution of spanish industrial activity, measured by the indices of industrial production, by means of Time Series analysis.
Rey, Pilar +2 more
core
A Sensor-Aware Decoupled Learning Framework for Robust Multi-Scale Time-Series Forecasting in Oil Production Systems. [PDF]
Sensors (Basel)Cheng G, Zhang W, Jin Z, Cai L.
europepmc +1 more source