Results 181 to 190 of about 13,892,744 (247)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Food systems transformation would reshape global agriculture. [PDF]

Nature
Gibson M, Sundiang M, Mason-D'Croz D, Diniz Oliveira T, Beier F, Benavidez L, Bos A, Chepeliev M, Doelman J, Dunston S, Fujimori S, Hasegawa T, Havlik P, Hristov J, Jägermeyr J, Kozicka M, Kuiper M, Kyle P, de Lange T, Bodirsky BL, Lotze-Campen H, Luchtenbelt H, Chen DM, Mishra A, Müller C, Nelson G, Palazzo A, Perez Dominguez I, Popp A, Sands R, Springmann M, Stehfest E, Sulser TB, Takahashi K, Tassinari G, Thom F, Thornton P, Tsuchiya K, van Zeist WJ, van Meijl H, van der Mensbrugghe D, Van Vuuren D, van Zanten HHE, Weindl I, Wiebe K, Zhao X, Herrero M.   +46 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review. [PDF]

Fluids Barriers CNS
Sluijters OJJ, Pooley JR, Singleton WGB.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Evaluating the influence of C/t on sensitivity to relative S+ production rate. [PDF]

J Exp Anal Behav
Blakemore ET, Morris SL.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Correction: Performance of large language models in neonatal resuscitation assessments versus healthcare providers: an exploratory study. [PDF]

Front Artif Intell
Frontiers Production Office.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Quantitative Characterization of Flow Hysteresis for Fractured-Vuggy Underground Gas Storage during High-Rate Injection and Production Based on Multiscale Digital Cores. [PDF]

ACS Omega
Li L, Wang M, Zhang L, Wang R, Yu P.
europepmc   +1 more source