Results 51 to 60 of about 4,556 (199)

Association between heroin dependence and prodynorphin gene polymorphisms

Brain Research Bulletin, 2011
Dynorphin peptides and k-opioid receptor are important in the rewarding effects of drugs of abuse such as heroin. This study examined potential association between heroin dependence and four single nucleotide polymorphisms (SNPs) of prodynorphin (PDYN) gene (rs35286281 in promoter region and rs1022563, rs2235749, rs910080 in 3'UTR).
S G, Wei, Y S, Zhu, J H, Lai, H X, Xue, Z Q, Chai, S B, Li   +5 more
openaire   +2 more sources

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Journal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong   +8 more
doaj   +1 more source

Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. [PDF]

PLoS ONE, 2011
BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.
Wenhua Han, Yukio Takamatsu, Hideko Yamamoto, Shinya Kasai, Shogo Endo, Tomoaki Shirao, Nobuhiko Kojima, Kazutaka Ikeda   +7 more
doaj   +1 more source

The relationship between protein and mrna expression of transcription repressor dream, c-fos and prodynorphin in modulating pain responses induced by formalin in the rat spinal cord. [PDF]

, 2011
Protein Downstream Regulatory Element Antagonist Modulator (DREAM) bertindak sebagai penindas transkripsi bagi gen c-Fos dan prodynorphin yang terlibat dalam proses kesakitan.
Long, Idris
core  

Chronic alcohol consumption and withdrawal do not induce cell death in the suprachiasmatic nucleus, but lead to irreversible depression of peptide immunoreactivity and mRNA levels [PDF]

, 1997
There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of various brain functions and behaviors. Because the suprachiasmatic nucleus (SCN) is widely recognized as the dominant pacemaker of the circadian system, we have ...
Almeida, OFX, Andrade, JP, Lieberman, AR, Madeira, MD, Paula-Barbosa, MM, Sousa, N   +5 more
core   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life

Frontiers in Neural Circuits
Olfactory dysfunctions decrease daily quality of life (QOL) in part by reducing the pleasure of eating. Olfaction plays an essential role in flavor sensation and palatability.
Koshi Murata, Koshi Murata, Ayako Maegawa, Ayako Maegawa, Ayako Maegawa, Yoshimasa Imoto, Yoshimasa Imoto, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source

Implanted Reuptake-deficient or Wild-type Dopaminergic Neurons Improve ON L-dopa Dyskinesias Without OFF-dyskinesias in a Rat Model of Parkinson's Disease [PDF]

, 2012
OFF-L-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease.
Caron, M. G., Gainetdinov, R. R., Hallett, Penelope Jane, Isacson, Ole Stefan, Patterson, M., Reske-Nielsen, C., Sotnikova, T. D., Vinuela, Angel   +7 more
core   +1 more source

Dysmorphic neurons express markers of inhibitory glycinergic signaling in focal cortical dysplasia IIb

Brain Pathology, Volume 36, Issue 2, March 2026.
Deep learning tissue mapping can guide region of interest selection for spatial transcriptomic analyses. Using this method, a transcriptional catalogue of focal cortical dysplasia type IIb was generated, revealing enrichment for markers of inhibitory glycinergic signaling in cytomegalic dysmorphic neurons.
Ameesha Paliwal, Kevin Faust, Okty Abbasi Borhani, Mugeng Liu, Lauren Omoto, Evelyn Rose Kamski‐Hennekam, Parsa Babaei Zadeh, Rifat Shahriar Sajid, Phedias Diamandis   +8 more
wiley   +1 more source