Results 71 to 80 of about 4,556 (199)
Dynamic up‐regulation of prodynorphin transcription in temporal lobe epilepsy [PDF]
Hippocampus, 2009 AbstractDynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to controls.
Susanne, Pirker +8 more
openaire +2 more sources
Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives
BioEssays, Volume 47, Issue 11, November 2025.Breathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Nathan A. Baertsch +4 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2018 Vadim Yuferov,* Eduardo R Butelman,* Mary Jeanne Kreek Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA *These authors contributed equally to this work Background: Cannabis use disorders (CUDs) cause ...
Yuferov V, Butelman ER, Kreek MJ
doaj
Neurobiology of Disease, 2014 A role for enhanced peptidergic transmission, either opioidergic or not, has been proposed for the generation of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID) on the basis of in situ hybridization studies showing that striatal ...
Mathieu Bourdenx +7 more
doaj +1 more source
Phosphorylation of ERK in Neurokinin 1 Receptor-Expressing Neurons in Laminae III and IV of the Rat Spinal Dorsal Horn Following Noxious Stimulation [PDF]
, 2007 Background There is a population of large neurons with cell bodies in laminae III and IV of the spinal dorsal horn which express the neurokinin 1 receptor (NK1r) and have dendrites that enter the superficial laminae. Although it has been shown that these
Erika Polgár +4 more
core +2 more sources
Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene [PDF]
Biological Psychology, 2011 The results of the current analyses present preliminary evidence of an association between putatively functional variation in the prodynorphin (PDYN) gene and a dimensional measure of disinhibited behavior. A 68bp sequence in the core promoter region of the PDYN gene was genotyped in a community sample of 1021 adults aged 30-54.
Janine D, Flory +4 more
openaire +2 more sources
Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2267-2277, October 2025.Targeting dependence‐ and/or stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) either by a viral knockdown in the nucleus accumbens (NAc) or by repeated systemic administration ...
Marcelo F. Lopez +4 more
wiley +1 more source
Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]
, 2016 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June +3 more
core +2 more sources
Functional Characteristics of Bioactive Millet Peptides: A Comprehensive Review
Future Postharvest and Food, Volume 2, Issue 3, Page 220-236, September 2025.The graphical abstract of this paper highlights the functional characteristics of bioactive peptides derived from millets. It is a promising ingredient and can be used in various applications in food, pharmaceuticals, and healthcare industries and possess biological functions.
Kouser Jan +10 more
wiley +1 more source
Proteasome targeted therapy in arthritis models -effects on pain and inflammation [PDF]
, 2010 The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators.
Ahmed, Aisha Siddiqah
core