Results 1 to 10 of about 569,127 (341)

Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children

Frontiers in Oncology, 2022
Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population.
Roberto Rivera-Luna, Roberto Rivera-Luna, Patricia Perez-Vera, Cesar Galvan-Diaz, Liliana Velasco-Hidalgo, Alberto Olaya-Vargas, Rocio Cardenas-Cardos, Marco Aguilar-Ortiz, Jesus Ponce-Cruz   +8 more
doaj   +1 more source

Bronchiolar Progenitor Cells [PDF]

Proceedings of the American Thoracic Society, 2009
A comprehensive appreciation of mechanisms regulating epithelial maintenance and repair in pulmonary airways is fundamental to our understanding of tissue remodeling and dysfunction in chronic lung disease. This review provides an update on current concepts that have emerged from recent work in the field of airway epithelial repair and progenitor cell ...
Huaiyong Chen, Keitaro Matsumoto, Barry R. Stripp   +2 more
openaire   +3 more sources

Categorisation of patients based on immune profiles: a new approach to identifying candidates for response to checkpoint inhibitors

Clinical & Translational Immunology, 2021
Objectives Inhibitors to the checkpoint proteins cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) and programmed cell death protein 1 (PD‐1) are becoming widely used in cancer treatment.
Svetlana Bornschlegl, Michael P Gustafson, Danae A Delivanis, Mabel Ryder, Minetta C Liu, George Vasmatzis, Chris L Hallemeier, Sean S Park, Lewis R Roberts, Ian F Parney, Diane F Jelinek, Allan B Dietz   +11 more
doaj   +1 more source

Characterization of The Retinal Progenitor Cells Generated Using Co-Culture Systems [PDF]

Cell Journal, 2022
Objective: Degeneration of the photoreceptors due to retinal disorders can affect vision, and even lead to blindness. Recently therapeutic progress in retinal degeneration, using human embryonic stem cells (hESCs), has been facing technical challenges,
Sara Momenzadeh, Fereshteh Karamali, Atefeh Atefi, Mohammad Hossein Nasr-Esfahani   +3 more
doaj   +1 more source

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

eLife, 2021
High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a
Tamar Tak, Giulio Prevedello, Gaël Simon, Noémie Paillon, Camélia Benlabiod, Caroline Marty, Isabelle Plo, Ken R Duffy, Leïla Perié   +8 more
doaj   +1 more source

Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. [PDF]

PLoS ONE, 2015
An appropriate liver-specific progenitor cell marker is a stepping stone in liver regenerative medicine. Here, we report brain isoform glycogen phosphorylase (GPBB) as a novel liver progenitor cell marker.
Yu-Wen Huang, Chien-Chang Chiu, Ja-Der Liang, Ling-Ling Chiou, Guan-Tarn Huang, Ming-Jiun Yu, Hsuan-Shu Lee   +6 more
doaj   +1 more source

Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows

Frontiers in Cell and Developmental Biology, 2022
Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, respectively) analyses in mice and human AT have ...
Tainara C. Michelotti, Brent R. Kisby, Lauryn S. Flores, Alexandra P. Tegeler, Mohamed Fokar, Chiquito Crasto, Chiquito Crasto, Chiquito Crasto, Bruno C. Menarim, Shavahn C. Loux, Clarissa Strieder-Barboza, Clarissa Strieder-Barboza   +11 more
doaj   +1 more source

Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Frontiers in Cell and Developmental Biology, 2022
Loss of muscle mass and strength contributes to decreased independence and an increased risk for morbidity and mortality. A better understanding of the cellular and molecular mechanisms underlying muscle atrophy therefore has significant clinical and ...
Emily Parker, Andrew Khayrullin, Andrew Kent, Bharati Mendhe, Khairat Bahgat Youssef El Baradie, Khairat Bahgat Youssef El Baradie, Kanglun Yu, Jeanene Pihkala, Yutao Liu, Meghan McGee-Lawrence, Maribeth Johnson, Jie Chen, Mark Hamrick   +12 more
doaj   +1 more source

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Frontiers in Cell and Developmental Biology, 2022
Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA).
Li Ding, Kaely Roeck, Cheng Zhang, Brooke Zidek, Esther Rodman, Yasmin Hernandez-Barco, Jin-San Zhang, Jin-San Zhang, William Bamlet, Ann Oberg, Lizhi Zhang, Nabeel Bardeesy, Hu Li, Daniel Billadeau   +13 more
doaj   +1 more source

Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy

Frontiers in Medicine, 2022
Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease characterized by progressive muscle wasting due to modifications in the DMD gene (exon deletions, nonsense mutations, intra-exonic insertions or deletions, exon duplications, splice site
Cedric Happi Mbakam, Cedric Happi Mbakam, Gabriel Lamothe, Gabriel Lamothe, Jacques P. Tremblay, Jacques P. Tremblay   +5 more
doaj   +1 more source