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Characterization of The Retinal Progenitor Cells Generated Using Co-Culture Systems [PDF]

open access: yesCell Journal, 2022
Objective: Degeneration of the photoreceptors due to retinal disorders can affect vision, and even lead to blindness. Recently therapeutic progress in retinal degeneration, using human embryonic stem cells (hESCs), has been facing technical challenges,
Sara Momenzadeh   +3 more
doaj   +1 more source

Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children

open access: yesFrontiers in Oncology, 2022
Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population.
Roberto Rivera-Luna   +8 more
doaj   +1 more source

Categorisation of patients based on immune profiles: a new approach to identifying candidates for response to checkpoint inhibitors

open access: yesClinical & Translational Immunology, 2021
Objectives Inhibitors to the checkpoint proteins cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) and programmed cell death protein 1 (PD‐1) are becoming widely used in cancer treatment.
Svetlana Bornschlegl   +11 more
doaj   +1 more source

Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. [PDF]

open access: yesPLoS ONE, 2015
An appropriate liver-specific progenitor cell marker is a stepping stone in liver regenerative medicine. Here, we report brain isoform glycogen phosphorylase (GPBB) as a novel liver progenitor cell marker.
Yu-Wen Huang   +6 more
doaj   +1 more source

Hematopoiesis Remains Permissive to Bone Marrow Transplantation After Expansion of Progenitors and Resumption of Blood Cell Production

open access: yesFrontiers in Cell and Developmental Biology, 2021
The immense regenerative power of hematopoietic tissue stems from the activation of the immature stem cells and the progenitor cells. After partial damage, hematopoiesis is reconstituted through a period of intense regeneration when blood cell production
Martin Báječný   +10 more
doaj   +1 more source

Stable human cartilage progenitor cell line stimulates healing of meniscal tears and attenuates post-traumatic osteoarthritis

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Meniscal tearing in the knee increases the risk of post-traumatic osteoarthritis (OA) in patients. The therapeutic application of tissue-specific mesenchymal progenitor cells is currently being investigated as an emerging biologic strategy to help ...
Salomi Desai   +8 more
doaj   +1 more source

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

open access: yesBioengineering, 2020
Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast
Salomi Desai, Chathuraka T. Jayasuriya
doaj   +1 more source

Beneficial effects of reconstituted high-density lipoprotein (rHDL) on circulating CD34+ cells in patients after an acute coronary syndrome [PDF]

open access: yes, 2017
Background: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS).
Alam, Mohammad Afaque   +15 more
core   +6 more sources

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

open access: yeseLife, 2021
High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a
Tamar Tak   +8 more
doaj   +1 more source

Formaldehyde Fixation of Extracellular Matrix Protein Layers for Enhanced Primary Cell Growth

open access: yesBio-Protocol, 2017
Coating tissue culture vessels with the components of the extracellular matrix such as fibronectin and collagens provides a more natural environment for primary cells in vitro and stimulates their proliferation.
Natalia Andreeva, Alexander Belyavsky
doaj   +1 more source

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