Results 11 to 20 of about 333,594 (247)
Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy
Frontiers in Medicine, 2022 Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease characterized by progressive muscle wasting due to modifications in the DMD gene (exon deletions, nonsense mutations, intra-exonic insertions or deletions, exon duplications, splice site
Cedric Happi Mbakam +5 more
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Bioengineering, 2020 Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast
Salomi Desai, Chathuraka T. Jayasuriya
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eLife, 2021 High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a
Tamar Tak +8 more
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Frontiers in Cell and Developmental Biology, 2022 Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, respectively) analyses in mice and human AT have ...
Tainara C. Michelotti +11 more
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Local Renin-Angiotensin System in Normal Hematopoietic and Multiple Myeloma-Related Progenitor Cells
Turkish Journal of Hematology, 2014 OBJECTIVE: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis.
Burak Uz +11 more
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Cell Therapy for Anal Sphincter Incontinence: Where Do We Stand?
Cells, 2021 Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate.
Alexandre Balaphas +9 more
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Myocardial Ischemia and Mobilization of Circulating Progenitor Cells
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThe response of progenitor cells (PCs) to transient myocardial ischemia in patients with coronary artery disease remains unknown. We aimed to investigate the PC response to exercise‐induced myocardial ischemia (ExMI) and compare it to flow ...
Muhammad Hammadah +30 more
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Joint Development Involves a Continuous Influx of Gdf5-Positive Cells
Cell Reports, 2016 Synovial joints comprise several tissue types, including articular cartilage, the capsule, and ligaments. All of these compartments are commonly assumed to originate from an early set of Gdf5-expressing progenitors populating the interzone domain.
Yulia Shwartz +3 more
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Cells, 2019 Tendon cells (TCs) are important for homeostatic maintenance in the healthy tendon and to promote tissue healing after injury. Further, resident and rare populations of tendon stem/progenitor cells, located at various sites within the tendon, contribute ...
Enrico Ragni +4 more
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Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution
Frontiers in Cell and Developmental Biology, 2022 During development, the decision of stem and progenitor cells to switch from proliferation to differentiation is of critical importance for the overall size of an organ. Too early a switch will deplete the stem/progenitor cell pool, and too late a switch
Samir Vaid, Wieland B. Huttner
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