Results 11 to 20 of about 11,013,611 (366)

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

eLife, 2021
High-throughput single-cell methods have uncovered substantial heterogeneity in the pool of hematopoietic stem and progenitor cells (HSPCs), but how much instruction is inherited by offspring from their heterogeneous ancestors remains unanswered. Using a
Tamar Tak, Giulio Prevedello, Gaël Simon, Noémie Paillon, Camélia Benlabiod, Caroline Marty, Isabelle Plo, Ken R Duffy, Leïla Perié   +8 more
doaj   +1 more source

Formaldehyde Fixation of Extracellular Matrix Protein Layers for Enhanced Primary Cell Growth

Bio-Protocol, 2017
Coating tissue culture vessels with the components of the extracellular matrix such as fibronectin and collagens provides a more natural environment for primary cells in vitro and stimulates their proliferation.
Natalia Andreeva, Alexander Belyavsky
doaj   +1 more source

Cell Therapy for Anal Sphincter Incontinence: Where Do We Stand?

Cells, 2021
Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate.
Alexandre Balaphas, Jeremy Meyer, Raphael P. H. Meier, Emilie Liot, Nicolas C. Buchs, Bruno Roche, Christian Toso, Leo H. Bühler, Carmen Gonelle-Gispert, Frédéric Ris   +9 more
doaj   +1 more source

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Science, 2019
A singular focus on fat Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes.
David Merrick, Alexander Sakers, Zhazira Irgebay, Chihiro Okada, C. Calvert, M. Morley, I. Percec, P. Seale   +7 more
semanticscholar   +1 more source

Isolation and Expansion of Mesenchymal Stem Cells from Murine Adipose Tissue

Bio-Protocol, 2017
Mesenchymal stem cells (MSCs) are currently intensively studied due to significant promise which they represent for successful implementations of future cell therapy clinical protocols. This in turn emphasizes importance of careful preclinical studies of
Natalia Andreeva, Alexandra Dalina, Alexander Belyavsky   +2 more
doaj   +1 more source

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

Autophagy, 2019
Cell-based therapies represent a very promising strategy to repair and regenerate the injured heart to prevent progression to heart failure. To date, these therapies have had limited success due to a lack of survival and retention of the infused cells ...
Mark A. Lampert, Amabel M. Orogo, Rita H. Najor, Babette C. Hammerling, Leonardo J. Leon, Bingyan J. Wang, Taeyong Kim, Mark A Sussman, Å. Gustafsson   +8 more
semanticscholar   +1 more source

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Frontiers in Cell and Developmental Biology, 2022
Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA).
Li Ding, Kaely Roeck, Cheng Zhang, Brooke Zidek, Esther Rodman, Yasmin Hernandez-Barco, Jin-San Zhang, Jin-San Zhang, William Bamlet, Ann Oberg, Lizhi Zhang, Nabeel Bardeesy, Hu Li, Daniel Billadeau   +13 more
doaj   +1 more source

Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows

Frontiers in Cell and Developmental Biology, 2022
Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, respectively) analyses in mice and human AT have ...
Tainara C. Michelotti, Brent R. Kisby, Lauryn S. Flores, Alexandra P. Tegeler, Mohamed Fokar, Chiquito Crasto, Chiquito Crasto, Chiquito Crasto, Bruno C. Menarim, Shavahn C. Loux, Clarissa Strieder-Barboza, Clarissa Strieder-Barboza   +11 more
doaj   +1 more source

Age-related inflammation triggers skeletal stem/progenitor cell dysfunction

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance As we age, our capacity for tissue repair and regeneration in response to injury declines. Accordingly, bone repair is delayed and impaired in older patients.
A. M. Josephson, V. Bradaschia-Correa, Sooyeon Lee, K. Leclerc, Karan S. Patel, Emma Muinos Lopez, H. Litwa, S. S. Neibart, Manasa Kadiyala, M. Z. Wong, M. Mizrahi, N. Yim, A. Ramme, K. Egol, P. Leucht   +14 more
semanticscholar   +1 more source

Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Frontiers in Cell and Developmental Biology, 2022
Loss of muscle mass and strength contributes to decreased independence and an increased risk for morbidity and mortality. A better understanding of the cellular and molecular mechanisms underlying muscle atrophy therefore has significant clinical and ...
Emily Parker, Andrew Khayrullin, Andrew Kent, Bharati Mendhe, Khairat Bahgat Youssef El Baradie, Khairat Bahgat Youssef El Baradie, Kanglun Yu, Jeanene Pihkala, Yutao Liu, Meghan McGee-Lawrence, Maribeth Johnson, Jie Chen, Mark Hamrick   +12 more
doaj   +1 more source