Results 101 to 110 of about 15,666 (259)

Management of cataract in Werner syndrome

Indian Journal of Ophthalmology, 2018
Werner syndrome (WS) is a rare progressive disorder. It is characterized by the appearance of unusually accelerated aging (progeria) including bilateral senile cataract. Here, we report a successful management of hypermature cataract in WS.
Rakhi Kusumesh, Bibhuti Prassan Sinha, Anita Ambastha, Santosh Kumar Thakur   +3 more
doaj   +1 more source

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

Cell Reports, 2018
Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline.
Ray Kreienkamp, Simona Graziano, Nuria Coll-Bonfill, Gonzalo Bedia-Diaz, Emily Cybulla, Alessandro Vindigni, Dale Dorsett, Nard Kubben, Luis Francisco Zirnberger Batista, Susana Gonzalo   +9 more
doaj   +1 more source

Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome [PDF]

, 2016
Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014Induced pluripotent stem cells (iPSCs) represent today an invaluable tool to create disease cell models for modeling and drug screening ...
Ferreira, L., Pereira, P., Praça, C., Rosa, S. C.   +3 more
core   +1 more source

The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers. [PDF]

, 2006
Hutchinson-Gilford progeria syndrome (HGPS) is a dominant autosomal premature aging syndrome caused by the expression of a truncated prelamin A designated progerin.
Buendia, Brigitte, Coppey-Moisan, Maïté, Courvalin, Jean-Claude, Delbarre, Erwan, Gaillard, Claire, Tramier, Marc   +5 more
core   +1 more source

Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome

Analytical Cellular Pathology, 2018
Background. Increased oxidative stress is a major cause of aging and age-related diseases. Erythrocytes serve as good model for aging studies. Dihydrotachysterol is known to induce premature aging feature in rats mimicking Hutchinson-Gilford progeria ...
Manoj Kumar Chaudhary, Syed Ibrahim Rizvi   +1 more
doaj   +1 more source

A combination of both proteomic and genetic approach to indentify de-regulated pathway in progeria, an accelerated aging disorder [PDF]

, 2011
Comunicaciones a ...
Arufe, M.C., Blanco, Francisco J., Calamia, Valentina, Fernández, P., Fuente, A. de la, Lesende, I., Mateos, Jesús, Rocha, Beatriz, Ruiz-Romero, Cristina   +8 more
core  

Current advances and future prospects of cell reprogramming in progeroid syndromes

Frontiers in Cell and Developmental Biology
Cell reprogramming consists in the reverse process to cell differentiation, making cells lose their identity and age-related characteristics and granting an increased potential for proliferation and redifferentiation on different lineages.
Lucas Moledo-Nodar, Víctor Celemín-Capaldi, Alejandro P. Ugalde, Alejandro P. Ugalde, José M. P. Freije, José M. P. Freije, José M. P. Freije   +6 more
doaj   +1 more source

Mutation in Genes FBN1, AKT1, and LMNA: Marfan Syndrome, Proteus Syndrome, and Progeria Share Common Systemic Involvement

International Journal of Medical Students, 2015
Genetic mutations are becoming more deleterious day by day. Mutations of Genes named FBN1, AKT1, LMNA result specific protein malfunction that in turn commonly cause Marfan syndrome, Proteus syndrome, and Progeria, respectively.
Tonmoy Biswas
doaj   +1 more source

The progeria research foundation 10th international scientific workshop; researching possibilities, ExTENding lives – webinar version scientific summary

, 2021
Leslie B. Gordon, Kelsey Tuminelli, Vicente Andrés, Judith Campisi, Mark W. Kieran, Lynn Doucette, A S Gordon   +6 more
openalex   +2 more sources

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome [PDF]

, 2012
Leslie B. Gordon, Monica E. Kleinman, David T. Miller, Donna Neuberg, Anita Giobbie‐Hurder, Marie Gerhard‐Herman, Leslie Smoot, Catherine M. Gordon, Robert Cleveland, Brian D. Snyder, Brian J. Fligor, W. Robert Bishop, Paul Statkevich, Amy Regen, Andrew L. Sonis, Susan Riley, Christine Ploski, Annette Correia, Nicolle Quinn, Nicole J. Ullrich, Ara Nazarian, Marilyn G. Liang, Susanna Y. Huh, Armin Schwartzman, Mark W. Kieran   +24 more
openalex   +1 more source