Results 41 to 50 of about 15,666 (259)

Progeria - the old children

Quality in Sport
Introduction and Purpose: Progeria, also known as Hutchinson-Gilford progeria syndrome, is a rare genetic disorder characterized by accelerated aging in children.
Dawid Dziedziński, Dawid Łoś, Aleksandra Nowak, Anita Janus, Agata Kaptur   +4 more
doaj   +1 more source

Implant Supported Prosthesis in a Patient with Progeria: Case Report

Biomolecules & Biomedicine, 2009
Prosthodontic rehabilitation can be accomplished with fixed, overdenture, complete, or implant-retained prostheses. Dental treatment overcomes the patient’s functional, psychological, esthetic and phonation problems.
Gözlem Ceylan, Nergiz Yılmaz, Özgün Şenyurt, Göknil Ergün Kunt   +3 more
doaj   +1 more source

The Potentials of Methylene Blue as an Anti-Aging Drug

Cells, 2021
Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new ...
Huijing Xue, Abhirami Thaivalappil, Kan Cao   +2 more
doaj   +1 more source

Mandibuloacral Dysplasia Caused by LMNA Mutations and Uniparental Disomy. [PDF]

, 2014
Mandibuloacral dysplasia (MAD) is a rare autosomal recessive disorder characterized by postnatal growth retardation, craniofacial anomalies, skeletal malformations, and mottled cutaneous pigmentation.
Bai, Shaochun, Das, Soma, Dempsey, Melissa, Dietz, Harry C, Jones, Marilyn C, Lozada, Anthony   +5 more
core   +3 more sources

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

Lessons in aging from Myc knockout mouse models

Frontiers in Cell and Developmental Biology, 2023
Despite MYC being among the most intensively studied oncogenes, its role in normal development has not been determined as Myc−/− mice do not survival beyond mid-gestation.
Edward V. Prochownik, Edward V. Prochownik, Edward V. Prochownik, Edward V. Prochownik, Huabo Wang   +4 more
doaj   +1 more source

From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotypes with Supercells [PDF]

, 2013
Cell heterogeneity and the inherent complexity due to the interplay of multiple molecular processes within the cell pose difficult challenges for current single-cell biology.
Banavar, Jayanth R., Biancotto, Angélique, Candia, Julian Marcelo, Cao, Kan, Dagur, Pradeep, Driscoll, Meghan, Losert, Wolfgang, Maritan, Amos, Maunu, Ryan, McCoy Jr., J Philip, Nida Sen, H., Nussenblatt, Robert B, Wei, Lai   +12 more
core   +5 more sources

Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]

, 2005
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases.
Courvalin, Jean-Claude, Worman, Howard,
core   +4 more sources

Early Onset Diabetes in Two Children due to Progeria, a Monogenic Disease of DNA Repair

JCRPE, 2020
Progeria syndrome is a rare disorder in childhood which causes accelerated systemic aging. Due to the accelerated aging process, disorders which normally occur only in old age will appear in these children at a much younger age.
Martin Holder, Valerie Schwitzgebel
doaj   +1 more source

MicroRNAs in age-related diseases [PDF]

, 2013
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders.
Jazbutyte V, Olivieri F, Pierluigi Nicotera, Stefanie Dimmeler, Yang J   +4 more
core   +1 more source