Results 11 to 20 of about 2,591,762 (410)
High progesterone receptor expression in prostate cancer is associated with clinical failure.
PLoS ONE, 2015 BackgroundProstate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking.
Thea Grindstad +9 more
doaj +2 more sources
Scientific Reports, 2017 Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors.
Mayu Kasubuchi +8 more
doaj +2 more sources
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Circulation, 2021 Supplemental Digital Content is available in the text. Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart ...
C. Sim +26 more
semanticscholar +1 more source
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor. [PDF]
Biochemical Pharmacology, 2020 The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men.
M. Baker, Y. Katsu
semanticscholar +1 more source
Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update.
Journal of Clinical Oncology, 2020 PURPOSE To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS A multidisciplinary international Expert Panel
K. Allison +21 more
semanticscholar +1 more source
Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility
Endocrine reviews, 2020 Selective progesterone receptor modulators (SPRMs) are a new class of compounds developed to target the progesterone receptor (PR) with a mix of agonist and antagonist properties.
M. Islam +3 more
semanticscholar +1 more source
Human Reproduction Update, 2020 BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis.
F. Reis +5 more
semanticscholar +1 more source
A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer
International Journal of Molecular Sciences, 2023 Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone
Léa Clusan +3 more
semanticscholar +1 more source
A novel therapeutic approach for treatment of catamenial epilepsy
Neurobiology of Disease, 2018 Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi +5 more
doaj +1 more source
The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis [PDF]
International Journal of Fertility and Sterility, 2019 Background Gelatinases degrade extracellular matrix (ECM) components to allow for physiological remodeling and contribute to pathological tissue destruction in endometriosis.
Sepideh Mousazadeh +4 more
doaj +1 more source