Results 11 to 20 of about 2,512,088 (315)

Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth. [PDF]

PLoS ONE, 2013
A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the ...
Steven M Yellon, Abigail E Dobyns, Hailey L Beck, James T Kurtzman, Robert E Garfield, Michael A Kirby   +5 more
doaj   +2 more sources

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling

Scientific Reports, 2017
Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors.
Mayu Kasubuchi, Keita Watanabe, Kanako Hirano, Daisuke Inoue, Xuan Li, Kazuya Terasawa, Morichika Konishi, Nobuyuki Itoh, Ikuo Kimura   +8 more
doaj   +2 more sources

Prognostic Significance of Progesterone Receptor–Positive Tumor Cells Within Immunohistochemically Defined Luminal A Breast Cancer [PDF]

Journal of Clinical Oncology, 2012
Aleix Prat, Maggie C.U. Cheang, Miguel Martín, Joel S. Parker, Eva Carrasco, Rosalía Caballero, Scott Tyldesley, Karen A. Gelmon, Philip S. Bernard, Torsten O. Nielsen, Charles M. Perou   +10 more
openalex   +2 more sources

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Nature Communications, 2022
Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated.
Valentina Scabia, Ayyakkannu Ayyanan, F. De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, A. Treboux, K. Zaman, A. Stravodimou, Didier Jallut, M. Fiche, Philipp Bucher, G. Ambrosini, George Sflomos, C. Brisken   +14 more
semanticscholar   +1 more source

Expression of Progesterone Receptor and Its Association with Clinicopathological Characteristics in Meningiomas: A Cross-Sectional Study

World Neurosurgery: X, 2021
Background: Meningiomas that are progesterone receptor positive have a low recurrence rate and good prognosis compared to those that are progesterone receptor negative.
Leah Mnango, Angela Mwakimonga, Advera I. Ngaiza, James J. Yahaya, Edda Vuhahula, Amos R. Mwakigonja   +5 more
doaj   +1 more source

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart ...
C. Sim, B. Phipson, M. Ziemann, Haloom Rafehi, R. Mills, K. Watt, K. D. Abu-Bonsrah, R. Kalathur, H. Voges, Doan T Dinh, M. ter Huurne, Céline J. Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, L. Delbridge, R. Robker, P. Gregorevic, C. D. dos Remedios, S. Lal, A. Piers, I. Konstantinov, D. Elliott, A. El-Osta, A. Oshlack, James E. Hudson, E. Porrello   +26 more
semanticscholar   +1 more source

Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor. [PDF]

Biochemical Pharmacology, 2020
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men.
M. Baker, Y. Katsu
semanticscholar   +1 more source

Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. [PDF]

PLoS ONE, 2014
Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth without a pre-labor drop in maternal progesterone levels.
Toni N Welsh, Jonathan J Hirst, Hannah Palliser, Tamas Zakar   +3 more
doaj   +1 more source

Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS A multidisciplinary international Expert Panel
K. Allison, M. Hammond, M. Dowsett, Shannon E McKernin, L. Carey, P. Fitzgibbons, D. Hayes, S. Lakhani, M. Chávez-MacGregor, J. Perlmutter, C. Perou, M. Regan, D. Rimm, W. Symmans, E. Torlakovic, E. Torlakovic, Leticia Varella, G. Viale, G. Viale, T. Weisberg, L. McShane, A. Wolff   +21 more
semanticscholar   +1 more source

Progesterone Signaling and Mammalian Ovarian Follicle Growth Mediated by Progesterone Receptor Membrane Component Family Members

Cells, 2022
How progesterone influences ovarian follicle growth is a difficult question to answer because ovarian cells synthesize progesterone and express not only the classic nuclear progesterone receptor but also members of the progestin and adipoQ receptor ...
John J. Peluso
doaj   +1 more source