Results 21 to 30 of about 4,627,535 (339)

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Nature Communications, 2022
Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated.
Valentina Scabia, Ayyakkannu Ayyanan, F. De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, A. Treboux, K. Zaman, Athina Stravodimou, Didier Jallut, M. Fiche, Philipp Bucher, G. Ambrosini, George Sflomos, C. Brisken   +14 more
semanticscholar   +1 more source

Expression of Progesterone Receptor and Its Association with Clinicopathological Characteristics in Meningiomas: A Cross-Sectional Study

World Neurosurgery: X, 2021
Background: Meningiomas that are progesterone receptor positive have a low recurrence rate and good prognosis compared to those that are progesterone receptor negative.
Leah Mnango, Angela Mwakimonga, Advera I. Ngaiza, James J. Yahaya, Edda Vuhahula, Amos R. Mwakigonja   +5 more
doaj   +1 more source

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart ...
C. Sim, B. Phipson, M. Ziemann, H. Rafehi, R. Mills, K. Watt, K. D. Abu-Bonsrah, R. Kalathur, H. Voges, D. Dinh, M. ter Huurne, Céline J. Vivien, A. Kaspi, H. Kaipananickal, Alejandro Hidalgo, L. Delbridge, R. Robker, P. Gregorevic, C. dos Remedios, S. Lal, A. Piers, I. Konstantinov, D. Elliott, A. El-Osta, A. Oshlack, J. Hudson, E. Porrello   +26 more
semanticscholar   +1 more source

Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. [PDF]

PLoS ONE, 2014
Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth without a pre-labor drop in maternal progesterone levels.
Toni N Welsh, Jonathan J Hirst, Hannah Palliser, Tamas Zakar   +3 more
doaj   +1 more source

Discordance of Diagnostic Core Biopsy and Final Histopathology Performed after Surgical Resection of Breast Cancer

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the frequency of discordance of receptor status in our breast cancer patients, find out its causes, and suggest remedial measures. Study Design: Retrospective longitudinal study.
Said Zaman Khan, Syeda Rifaat Qamar, Muhammad Sohaib Nadeem, Ayesha Khan, Afroz Mushtaq, Maria Mir Jan   +5 more
doaj   +1 more source

Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS A multidisciplinary international Expert Panel
K. Allison, M. Hammond, M. Dowsett, Shannon E. McKernin, L. Carey, P. Fitzgibbons, D. Hayes, S. Lakhani, M. Chávez-Macgregor, J. Perlmutter, C. Perou, M. Regan, D. Rimm, W. Symmans, E. Torlakovic, Leticia Varella, G. Viale, T. Weisberg, L. McShane, A. Wolff   +19 more
semanticscholar   +1 more source

Loss of progesterone receptor-mediated actions induce preterm cellular and structural remodeling of the cervix and premature birth. [PDF]

PLoS ONE, 2013
A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the ...
Steven M Yellon, Abigail E Dobyns, Hailey L Beck, James T Kurtzman, Robert E Garfield, Michael A Kirby   +5 more
doaj   +1 more source

Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility

Endocrine reviews, 2020
Selective progesterone receptor modulators (SPRMs) are a new class of compounds developed to target the progesterone receptor (PR) with a mix of agonist and antagonist properties.
Md. Soriful Islam, Sadia Afrin, Sarah Jones, J. Segars   +3 more
semanticscholar   +1 more source

Progesterone Signaling and Mammalian Ovarian Follicle Growth Mediated by Progesterone Receptor Membrane Component Family Members

Cells, 2022
How progesterone influences ovarian follicle growth is a difficult question to answer because ovarian cells synthesize progesterone and express not only the classic nuclear progesterone receptor but also members of the progestin and adipoQ receptor ...
John J. Peluso
doaj   +1 more source

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

Human Reproduction Update, 2020
BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis.
F. Reis, L. M. Coutinho, S. Vannuccini, F. Batteux, C. Chapron, F. Petraglia   +5 more
semanticscholar   +1 more source