Results 11 to 20 of about 220,321 (314)

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +2 more sources

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis [PDF]

International Journal of Fertility and Sterility, 2019
Background Gelatinases degrade extracellular matrix (ECM) components to allow for physiological remodeling and contribute to pathological tissue destruction in endometriosis.
Sepideh Mousazadeh, Azadeh Ghaheri, Maryam Shahhoseini, Reza Aflatoonian, Parvaneh Afsharian   +4 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Estrogen and progesterone receptor expression in breast carcinoma

Journal of Pathology of Nepal, 2011
Background: Breast carcinoma is the most common malignancy diagnosed among women worldwide and second leading cause of cancer mortality. One of the hallmarks of the disease is expression of estrogen receptor and progesterone receptor that ultimately ...
TB Pathak, R Bashyal, CB Pun, S Shrestha, S Bastola, S Neupane, BR Poudel, MC Lee   +7 more
doaj   +1 more source

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Pathological implication of progesterone receptor expression in patients diagnosed with meningioma [PDF]

Romanian Journal of Neurology
Objectives. To assess the progesterone receptor expression in meningioma patients and to characterize the histopathological and demographic features of them. Materials and methods.
Murooj Jassim Mohammed, Hadeel Ismail Mohsin, Hind Suhail Ali, Asaad F. Albayati   +3 more
doaj   +1 more source

Progestin receptor-mediated reduction of anxiety-like behavior in male rats. [PDF]

PLoS ONE, 2008
BACKGROUND: It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular ...
Catherine J Auger, Robin M Forbes-Lorman
doaj   +1 more source

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]

, 2017
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D, Denner, Larry, Edwards, Dean P, Harling, Moriah, Huang, Shixia, Im, Dana D, Lichti, Cheryl F, Nettles, Sabin A, Pattanayak, Cassandra, Sellers, Katherine J, Srivastava, Deepak P, Tetel, Marc J, Vardar-Ulu, Didem   +12 more
core   +3 more sources

Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor [PDF]

, 2016
To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular ...
Frizziero, Luisa, Midena, Edoardo, Miglionico, Giacomo, Parrozzani, Raffaele, Perrini, Pierdavide, Pilotto, Elisabetta, Pulze, Serena, Testi, Ilaria   +7 more
core   +1 more source