Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. [PDF]
PLoS ONE, 2011 Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development.
Jarom Heijmans +11 more
doaj +1 more source
The importance of simultaneous determination of breast cancer biomarkers [PDF]
Archive of Oncology, 2002 It is shown that steroid hormone receptors by themselves are not sufficiently strong prognostic factors in management of breast cancer. For that reason, simultaneous consideration of different biomarkers seems to be more appropriate for clinical use, i.e.
Markićević Milan +3 more
doaj +1 more source
Progesterone Receptor Negative
Definitions, 2020 Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie w ...
N. Institute
semanticscholar +1 more source
A novel therapeutic approach for treatment of catamenial epilepsy
Neurobiology of Disease, 2018 Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi +5 more
doaj +1 more source
A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer
International Journal of Molecular Sciences, 2023 Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone
Léa Clusan +3 more
semanticscholar +1 more source
Progesterone Regulation of the Progesterone Receptor in Rat Gonadotropes* [PDF]
Endocrinology, 2000 For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms.
J L, Turgeon, D W, Waring
openaire +2 more sources
Effects of Progesterone and Its Antagonist Mifepristone on Progesterone Receptor A Expression in Human Umbilical Vein Endothelial Cells [PDF]
, 2009 Effects of female steroid hormones on endothelial cells are gaining increased importance due to several studies on the effects of hormonal treatment on cardiovascular risk.
Ochsenkühn, Robert +6 more
core +1 more source
The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis [PDF]
International Journal of Fertility and Sterility, 2019 Background Gelatinases degrade extracellular matrix (ECM) components to allow for physiological remodeling and contribute to pathological tissue destruction in endometriosis.
Sepideh Mousazadeh +4 more
doaj +1 more source
Internalisation of membrane progesterone receptor-α after treatment with progesterone: Potential involvement of a clathrin-dependent pathway [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund.Internalisation and recycling of seven trans-membrane domain receptors is a critical regulatory event for their signalling.
Reynolds, A +5 more
core +1 more source
Estrogen and progesterone receptor expression in breast carcinoma
Journal of Pathology of Nepal, 2011 Background: Breast carcinoma is the most common malignancy diagnosed among women worldwide and second leading cause of cancer mortality. One of the hallmarks of the disease is expression of estrogen receptor and progesterone receptor that ultimately ...
TB Pathak +7 more
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