Results 31 to 40 of about 157,138 (359)

Incorporating progesterone receptor expression into the PREDICT breast prognostic model

, 2022
Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of ...
Hartman, Mikael, Margolin, Sara, Couch, Fergus J, Winqvist, Robert, Presneau, Nadege, Andrulis, Irene L, Ito, Hidemi, Anton-Culver, Hoda, Jung, Audrey, Eccles, Diana M, Kang, Daehee, Tawfiq, Essa, Easton, Douglas F, Bolla, Manjeet K, Torres, Diana, Hall, Per, Floris, Giuseppe, Castelao, Jose E, Abubakar, Mustapha, Jakubowska, Anna, González-Neira, Anna, van Deurzen, Carolien H M, Schoemaker, Minouk J, García-Closas, Montserrat, Howell, Sacha J, Osorio, Ana, Bonanni, Bernardo, Offit, Kenneth, Newman, William G, Lubiński, Jan, Beckmann, Matthias W, Hou, Ming-Feng, Nevanlinna, Heli, Lambrechts, Diether, Hein, Alexander, Czene, Kamila, Cross, Simon S, Devilee, Peter, Dunning, Alison M, Schochter, Fabienne, Gabrielson, Marike, Evans, D Gareth, Pharoah, Paul D P, Li, Jingmei, Giles, Graham G, Teras, Lauren R, Blows, Fiona M, Schmidt, Marjanka K, Hamann, Ute, Harkness, Elaine F, Choi, Ji-Yeob, Eriksson, Mikael, Vachon, Celine M, Manoochehri, Mehdi, Pylkäs, Katri, Schneeweiss, Andreas, Kristensen, Vessela N, Park, Sue K, Blomqvist, Carl, Fox, Stephen, Burwinkel, Barbara, Williams, Justin A, Gago-Dominguez, Manuela, García-Sáenz, José A, Radice, Paolo, Dwek, Miriam, Shen, Chen-Yang, Briceno, Ignacio, Haeberle, Lothar, Wendt, Camilla, Ernst, Kristina, Sinn, Peter, Hooning, Maartje J, John, Esther M, Fink, Visnja, Dörk, Thilo, Clarke, Christine L, Haiman, Christopher A, Teo, Soo Hwang, ABCTB Investigators, Bojesen, Stig E, Tapper, William J, Rack, Brigitte, Romero, Atocha, Patel, Alpa V, Milne, Roger L, Rennert, Gad, Mulligan, Anna Marie, Camp, Nicola J, Swerdlow, Anthony J, Figueroa, Jonine D, Fasching, Peter A, Cox, Angela, Grootes, Isabelle, Janni, Wolfgang, Elwood, Mark, Park-Simon, Tjoung-Won, Saloustros, Emmanouil, kConFab Investigators, Sawyer, Elinor J, Keeman, Renske, Matsuo, Keitaro, Kwong, Ava, Taib, Nur Aishah Mohd, Shibli, Rana   +104 more
core   +1 more source

Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels

Indonesian Journal of Obstetrics and Gynecology
Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens.
Suryanti, Mayasari Putri Ardela, Eka Frenty Hadiningsih, Sri Winarsih, Noorhamdani, Tatit Nurseta, Eviana Norahmawati   +6 more
doaj   +1 more source

Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types

BMC Genomics, 2022
Background The endometrium is a heterogeneous tissue composed of luminal epithelial (LE), glandular epithelial (GE), and stromal cells (ST), experiencing progesterone regulated dynamic changes during the estrous cycle.
Gonçalo Pereira, Yongzhi Guo, Elisabete Silva, Claudia Bevilacqua, Gilles Charpigny, Luís Lopes-da-Costa, Patrice Humblot   +6 more
doaj   +1 more source

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Scientific Reports, 2017
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release,
Wen He, Xiaofeng Li, Daniel Adekunbi, Yali Liu, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Hormonal modulators of glial ABCA1 and apoE levels[S]

Journal of Lipid Research, 2013
Apolipoprotein E (apoE) is the major lipid carrier in the central nervous system. As apoE plays a major role in the pathogenesis of Alzheimer disease (AD) and also mediates repair pathways after several forms of acute brain injury, modulating the ...
Jianjia Fan, Yoko Shimizu, Jeniffer Chan, Anna Wilkinson, Ayaka Ito, Peter Tontonoz, Edie Dullaghan, LiisaA.M. Galea, Tom Pfeifer, Cheryl L. Wellington   +9 more
doaj   +1 more source

The rate of estrogen receptor‐conversion associated with tumor progression in estrogen receptor‐positive breast cancer patients following adjuvant Tamoxifen administration

Cancer Reports, 2022
Background Hormone Receptor (HR)‐discordance between primary breast cancer and metastasis is a known biological phenomenon. Discordance studies usually comprise a heterogeneous group of HR‐positive and negative patients and allow for the comparison of ...
Sirus Djahansouzi, Bettina Hanstein, Daniel Rein, Michel Clees, Werner Rath   +4 more
doaj   +1 more source

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. [PDF]

, 2011
Summary In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using
Lenhard, Miriam, Toth, Bettina, Jeschke, Udo, Klaus Friese, Weissenbacher, Tobias, Mayr, Doris, Julia Gallwas, Udo Jeschke, Nina Ditsch, Tobias Weissenbacher, Christian Dannecker, Gallwas, Julia, Dannecker, Christian, Miriam Lenhard, Ditsch, Nina, Friese, Klaus, Doris Mayr, Bettina Toth   +17 more
core   +1 more source

Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy [PDF]

, 2020
The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely ...
Ørbo, Anne, Sager, Georg, Sletten, Elise Thoresen, Smaglyukova, Natalia   +3 more
core   +1 more source

Progesterone receptors:animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer [PDF]

, 2002
Progesterone and estradiol, and their nuclear receptors, play essential roles in the physiology of the reproductive tract, the mammary gland and the nervous system.
Lanari, Claudia Lee Malvina, Molinolo, Alfredo A.   +1 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source