Results 51 to 60 of about 157,138 (359)

Progesterone receptor modulators for endometriosis [PDF]

Cochrane Database of Systematic Reviews, 2017
Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of ...
Jing, Fu, Hao, Song, Min, Zhou, Huili, Zhu, Yuhe, Wang, Hengxi, Chen, Wei, Huang   +6 more
openaire   +2 more sources

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Insulin-like growth factor binding protein-6 modulates proliferative antagonism in response to progesterone in breast cancer

Frontiers in Endocrinology
Breast cancer is one of the most diagnosed cancers worldwide. The insulin-like growth factor (IGF) system promotes proliferation and survival in breast cancer cells and is regulated by 6 insulin-like growth factor binding proteins (IGFBPs).
Francisco J. Lariz, Pacha B. Botero, Isabella Shoffstall, Kevin D. Houston   +3 more
doaj   +1 more source

Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis

Cells, 2020
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). These cells arise during the embryonic development by the specification of the neural stem cells to oligodendroglial progenitor cells (OPC); newly formed OPC proliferate ...
Juan Carlos González-Orozco, Aylin Del Moral-Morales, Ignacio Camacho-Arroyo   +2 more
doaj   +1 more source

Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]

, 2014
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome, and the choice of therapy.
Carmen Criscitiello, Thompson, Alastair M., Locatelli, Marzia, Curigliano, Giuseppe, Orsi, Franco, F. Orsi, Fabrice André, Criscitiello, Carmen, Minchella, Ida, M. Locatelli, F. André, Thompson, Alastair M, Marzia Locatelli, Giuseppe Curigliano, Curigliano, Guiseppe, Ida Minchella, De Laurentiis, Michele, Lucia Gelao, Luca Fumagalli, Franco Orsi, Esposito, Angela, Goldhirsch, Aron, Angela Esposito, A. M. Thompson, DE LAURENTIIS, MICHELINO, L. Fumagalli, A. Goldhirsch, André, Fabrice, Michele De Laurentiis, Alastair M Thompson, A. Esposito, Fumagalli, Luca, G. Curigliano, M. De Laurentiis, Aron Goldhirsch, C. Criscitiello, L. Gelao, Gelao, Lucia, I. Minchella   +38 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

Stem Cell Reports, 2015
Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of ...
Yu-Jia Shiah, Pirashaanthy Tharmapalan, Alison E. Casey, Purna A. Joshi, Trevor D. McKee, Hartland W. Jackson, Alexander G. Beristain, Michelle A. Chan-Seng-Yue, Gary D. Bader, John P. Lydon, Paul D. Waterhouse, Paul C. Boutros, Rama Khokha   +12 more
doaj   +1 more source

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]

, 2011
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti, Henriet, Patrick, Giulia Grimaldi, Poutanen, Matti,, Steel, Jennifer H., Steel, Jennifer H, Jan J. Brosens, Matti Poutanen, Brosens, Jan J., Christian, Mark, Brosens, Jan J, Mark Christian, Grimaldi, Giulia, Jennifer H. Steel, Patrick Henriet   +14 more
core   +1 more source

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source