Results 51 to 60 of about 1,285,180 (252)

Progesterone action in the myometrium and decidua in preterm birth [PDF]

, 2012
Progesterone is central to many reproductive processes and is critical in regulating the menstrual cycle and maintaining pregnancy. We discuss here similarities in the molecular mechanisms that regulate the process of decidualisation in endometrial ...
Blanks, Andrew M., Brosens, Jan J.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Progesterone receptor modulators for endometriosis [PDF]

Cochrane Database of Systematic Reviews, 2017
Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of ...
Jing, Fu, Hao, Song, Min, Zhou, Huili, Zhu, Yuhe, Wang, Hengxi, Chen, Wei, Huang   +6 more
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

High progesterone receptor expression in prostate cancer is associated with clinical failure.

PLoS ONE, 2015
BackgroundProstate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking.
Thea Grindstad, Sigve Andersen, Samer Al-Saad, Tom Donnem, Yury Kiselev, Christian Nordahl Melbø-Jørgensen, Kaja Skjefstad, Lill-Tove Busund, Roy M Bremnes, Elin Richardsen   +9 more
doaj   +1 more source

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. [PDF]

, 2011
Summary In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using
Lenhard, Miriam, Toth, Bettina, Jeschke, Udo, Klaus Friese, Weissenbacher, Tobias, Mayr, Doris, Julia Gallwas, Udo Jeschke, Nina Ditsch, Tobias Weissenbacher, Christian Dannecker, Gallwas, Julia, Dannecker, Christian, Miriam Lenhard, Ditsch, Nina, Friese, Klaus, Doris Mayr, Bettina Toth   +17 more
core   +1 more source

Incorporating progesterone receptor expression into the PREDICT breast prognostic model

, 2022
Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of ...
Hartman, Mikael, Margolin, Sara, Couch, Fergus J, Winqvist, Robert, Presneau, Nadege, Andrulis, Irene L, Ito, Hidemi, Anton-Culver, Hoda, Jung, Audrey, Eccles, Diana M, Kang, Daehee, Tawfiq, Essa, Easton, Douglas F, Bolla, Manjeet K, Torres, Diana, Hall, Per, Floris, Giuseppe, Castelao, Jose E, Abubakar, Mustapha, Jakubowska, Anna, González-Neira, Anna, van Deurzen, Carolien H M, Schoemaker, Minouk J, García-Closas, Montserrat, Howell, Sacha J, Osorio, Ana, Bonanni, Bernardo, Offit, Kenneth, Newman, William G, Lubiński, Jan, Beckmann, Matthias W, Hou, Ming-Feng, Nevanlinna, Heli, Lambrechts, Diether, Hein, Alexander, Czene, Kamila, Cross, Simon S, Devilee, Peter, Dunning, Alison M, Schochter, Fabienne, Gabrielson, Marike, Evans, D Gareth, Pharoah, Paul D P, Li, Jingmei, Giles, Graham G, Teras, Lauren R, Blows, Fiona M, Schmidt, Marjanka K, Hamann, Ute, Harkness, Elaine F, Choi, Ji-Yeob, Eriksson, Mikael, Vachon, Celine M, Manoochehri, Mehdi, Pylkäs, Katri, Schneeweiss, Andreas, Kristensen, Vessela N, Park, Sue K, Blomqvist, Carl, Fox, Stephen, Burwinkel, Barbara, Williams, Justin A, Gago-Dominguez, Manuela, García-Sáenz, José A, Radice, Paolo, Dwek, Miriam, Shen, Chen-Yang, Briceno, Ignacio, Haeberle, Lothar, Wendt, Camilla, Ernst, Kristina, Sinn, Peter, Hooning, Maartje J, John, Esther M, Fink, Visnja, Dörk, Thilo, Clarke, Christine L, Haiman, Christopher A, Teo, Soo Hwang, ABCTB Investigators, Bojesen, Stig E, Tapper, William J, Rack, Brigitte, Romero, Atocha, Patel, Alpa V, Milne, Roger L, Rennert, Gad, Mulligan, Anna Marie, Camp, Nicola J, Swerdlow, Anthony J, Figueroa, Jonine D, Fasching, Peter A, Cox, Angela, Grootes, Isabelle, Janni, Wolfgang, Elwood, Mark, Park-Simon, Tjoung-Won, Saloustros, Emmanouil, kConFab Investigators, Sawyer, Elinor J, Keeman, Renske, Matsuo, Keitaro, Kwong, Ava, Taib, Nur Aishah Mohd, Shibli, Rana   +104 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Insulin-like growth factor binding protein-6 modulates proliferative antagonism in response to progesterone in breast cancer

Frontiers in Endocrinology
Breast cancer is one of the most diagnosed cancers worldwide. The insulin-like growth factor (IGF) system promotes proliferation and survival in breast cancer cells and is regulated by 6 insulin-like growth factor binding proteins (IGFBPs).
Francisco J. Lariz, Pacha B. Botero, Isabella Shoffstall, Kevin D. Houston   +3 more
doaj   +1 more source

Differential expression of progesterone receptor isoforms related to PGR +331g/a polymorphism in endometriosis: A case-control study

International Journal of Reproductive BioMedicine, 2019
Background Endometriosis are defined as a progesterone-resistance disease. Two progesterone receptor (PR) isoforms, namely PR-A and PR-B, mediate the special effects of progesterone.
Sepideh Mousazadeh, Azadeh Ghaheri, Maryam Shahhoseini, Reza Aflatoonian, Parvaneh Afsharian   +4 more
doaj   +1 more source